Catalog No.
YHJ91901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala60-Lys204
Predicted molecular weight
18.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6R0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Numb-R, Numb-like protein, NUMBL, Numb-related protein
Numb and NumbL inhibit melanoma tumor growth by influencing the immune microenvironment., PMID:39558287
The Role of NOTCH Pathway Genes in the Inherited Susceptibility to Aortic Stenosis., PMID:39057646
ZFHX3 methylation in peripheral blood monocytes as a potential biomarker for pancreatic cancer detection., PMID:38853072
Septin 7 interacts with Numb to preserve sarcomere structural organization and muscle contractile function., PMID:38695862
Identification of a novel lymphangiogenesis signature associated with immune cell infiltration in colorectal cancer based on bioinformatics analysis., PMID:38167072
Identification of biomarkers associated with pediatric asthma using machine learning algorithms: A review., PMID:38013370
Comprehensive pan-cancer analysis of expression profiles and prognostic significance for NUMB and NUMBL in human tumors., PMID:37657045
SEPTIN 7 INTERACTS WITH NUMB TO PRESERVE SARCOMERE STRUCTURAL ORGANIZATION AND MUSCLE CONTRACTILE FUNCTION., PMID:37461567
Identification of Somatic Mutations in Plasma Cell-Free DNA from Patients with Metastatic Oral Squamous Cell Carcinoma., PMID:37373553
The Adaptor Protein NumbL Is Involved in the Control of Glucolipotoxicity-Induced Pancreatic Beta Cell Apoptosis., PMID:36834720
Translocations and Gene Fusions in Sinonasal Malignancies., PMID:36753024
The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children., PMID:36282598
Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature., PMID:35978013
SLC8A1 antisense RNA 1 suppresses papillary thyroid cancer malignant progression via the FUS RNA binding protein (FUS)/NUMB like endocytic adaptor protein (Numbl) axis., PMID:35599603
Notch, Numb and Numb-like responses to exercise-induced muscle damage in human skeletal muscle., PMID:35562322
Gypensapogenin I Suppresses Cell Proliferation in Triple-Negative Breast Cancer Via Triggering the Closure of AKT/GSK3β/β-Catenin and Notch-1 Signaling Pathways., PMID:35465659
Numb and Numblike regulate sarcomere assembly and maintenance., PMID:35104799
The Spatiotemporal Expression of Notch1 and Numb and Their Functional Interaction during Cardiac Morphogenesis., PMID:34571841
miR-335 modulates Numb alternative splicing via targeting RBM10 in endometrial cancer., PMID:31894898
Elucidating the expression and function of Numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM)., PMID:31888545
Signatures of altered DNA methylation gene expression after central and peripheral nerve injury., PMID:31691285
Cardiomyocyte orientation modulated by the Numb family proteins-N-cadherin axis is essential for ventricular wall morphogenesis., PMID:31300538
Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors., PMID:31129078
NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts., PMID:30455992
Recurrent Fusion Gene ADCK4-NUMBL in Cutaneous Squamous Cell Carcinoma Mediates Cell Proliferation., PMID:30395845
β1-integrin is a cell-autonomous factor mediating the Numb pathway for cardiac progenitor maintenance., PMID:29653101
NUMB and NUMBL differences in gene regulation., PMID:29507685
COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression., PMID:29092026
Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4., PMID:29042443
NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis., PMID:28974699
Numb regulates somatic cell lineage commitment during early gonadogenesis in mice., PMID:28360133
Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice., PMID:28347671
Adaptor proteins NUMB and NUMBL promote cell cycle withdrawal by targeting ERBB2 for degradation., PMID:28067668
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy., PMID:27613838
Up-regulation of microRNA let-7c by quercetin inhibits pancreatic cancer progression by activation of Numbl., PMID:27521217
Numb and Numbl act to determine mammary myoepithelial cell fate, maintain epithelial identity, and support lactogenesis., PMID:27383182
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism., PMID:26407342
Regulation of vascular endothelial growth factor receptor function in angiogenesis by numb and numb-like., PMID:26069237
Numb family proteins: novel players in cardiac morphogenesis and cardiac progenitor cell differentiation., PMID:25883210
Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling., PMID:25535389
Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors., PMID:24843018
Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation., PMID:24335256
NumbL is essential for Xenopus primary neurogenesis., PMID:24125469
Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol., PMID:23923645
Numblike regulates proliferation, apoptosis, and invasion of lung cancer cell., PMID:23681800
Regulation of lung cancer metastasis by Klf4-Numb-like signaling., PMID:23440423
Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis., PMID:23041384
Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart., PMID:22865640
MiR-34a represses Numbl in murine neural progenitor cells and antagonizes neuronal differentiation., PMID:22701667
Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation., PMID:22593207
For research use only. Not for human or drug use.
