Catalog No.
YHJ91501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser141-Pro384
Predicted molecular weight
28.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6M1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hepatocellular carcinoma autoantigen p62, IMP2, IGF-II mRNA-binding protein 2, IMP-2, VICKZ2, VICKZ family member 2, IGF2BP2, IGF2 mRNA-binding protein 2, Insulin-like growth factor 2 mRNA-binding protein 2
ADAM32 Oncogene in Hepatoblastoma Is Regulated by IGF2BP2., PMID:40507253
Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction., PMID:40504123
DeSUMOylation of IGF2BP2 Promotes Neuronal Differentiation of OM-MSCs by Stabilizing SOX11 to Ameliorate Brain Injury After Intracerebral Hemorrhage., PMID:40485217
RNA m6A dynamics promote transcription and RNA stability of bivalent genes during iPSC-induced generation of human lung progenitors., PMID:40483690
SNORD88B promotes proliferation and invasion of trophoblast by regulating G3BP1 m6 A modification and alternative splicing., PMID:40471366
METTL14-Mediated M6A Modification of LINC01094 Induces Glucose Metabolic Reprogramming in Breast Cancer by Recruiting the PKM2/JMJD5 Complex., PMID:40470773
IGF2BP2 regulates gastric cancer radiotherapy resistance through HIF1α-mediated glycolysis., PMID:40469197
METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension., PMID:40451326
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
cIAP2-mediated IGF2BP2 ubiquitination and degradation regulate cardiomyocyte apoptosis via stabilizing m6A-modified BAX mRNA in myocardial infarction., PMID:40447880
Post-transcriptional regulation of H19 by m6A reader proteins: H19 stability versus miR-675 biogenesis., PMID:40447192
Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer., PMID:40445765
Integration of bioinformatics and identification of the role of m6A genes in NAFLD., PMID:40435202
The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease., PMID:40421968
The Long Noncoding RNA LINC02820 Promotes Tumor Growth and Metastasis Through Regulating MYH9 Expression in Esophageal Squamous Cell Carcinoma., PMID:40416600
EXPRESS: CircZFR involves propofol-triggered ferroptosis in lung cancer cells through the IGF2BP2/GPX4 axis., PMID:40411134
Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner., PMID:40387410
LNCAROD was stabilized through N6-methyladenosine methylation and exerted its anticancer effects in lung squamous cell carcinoma by inhibiting SIRT1 activity via CCAR2., PMID:40386722
circFADS2 inhibits ferroptosis associated with IGF2BP2-dependent SLC7A11 m6A modification in colorectal cancer cells., PMID:40386612
METTL3 promotes human amniotic epithelial stem cells differentiation into insulin-producing cells by regulation of MaFA expression., PMID:40374016
Dual Disruption of EGFR/PI3K Signaling: IGF2BP2 Targeting Reverses Anti-EGFR Resistance in CAFs-Infiltrated Oral Squamous Cell Carcinoma., PMID:40362183
Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality., PMID:40347943
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 Drives Subchondral Bone Damage in Temporomandibular Joint Osteoarthritis through Peroxisome Proliferator-Activated Receptor γ/C-FOS-Regulated Dual Pathways: Nuclear Factor of Activated T Cells 1 Signaling and Autophagy-Related 16-Like 2-Mediated Autophagy., PMID:40316216
Epigenetic Activation of PTCD3 Promotes CRC Glutamine Metabolism and Metastasis via IGF2BP2-Mediated SLC38A2 m6A Modification., PMID:40304977
m6A modification profiles of the CHO cells with differential recombinant protein expression using MeRIP-seq/RNA-seq., PMID:40288720
Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming., PMID:40272637
IGF2BP2-mediated m6A modifies SLC7A11 to regulate proliferation and ferroptosis in non-small cell lung cancer cells., PMID:40271825
PRMT1-Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma., PMID:40270464
The role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD., PMID:40264207
METTL16/IGF2BP2 axis enhances malignant progression and DDP resistance through up-regulating COL4A1 by mediating the m6A methylation modification of LAMA4 in hepatocellular carcinoma., PMID:40251670
N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway., PMID:40250752
Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis., PMID:40241612
Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation., PMID:40215175
IGF2BP2: an m6A reader that affects cellular function and disease progression., PMID:40205577
CircATP5C1 promotes triple-negative breast cancer progression by binding IGF2BP2 to modulate CSF-1 secretion., PMID:40176374
Stromal Stiffness-Regulated IGF2BP2 in Pancreatic Cancer Drives Immune Evasion via Sphingomyelin Metabolism., PMID:40158738
N6-methyladenosine-modified RNF220 induces cisplatin resistance and immune escape via regulating PDE10A K48-linked ubiquitination in bladder cancer., PMID:40158470
The m6A reader IGF2BP2 promotes pancreatic cancer progression through the m6A-SLC1A5-mTORC1 axis., PMID:40158101
Small Extracellular Vesicles Promote HBV Replication via METTL3-IGF2BP2-Mediated m6A Modification., PMID:40152398
Circ-ITCH promotes the ubiquitination degradation of HOXC10 to facilitate osteogenic differentiation in disuse osteoporosis through stabilizing BRCA1 mRNA via IGF2BP2-mediated m6A modification., PMID:40148953
Regulation of HSC development and function by Lin28b., PMID:40143971
IMPlications of IMP2 in RNA Biology and Disease., PMID:40141058
Role of insulin-like growth factor 2 mRNA binding protein 2 in regulating the progression of triple-negative breast cancer via binding with M6A methylation modified downstream target genes CCL20 and c-MYC., PMID:40137853
METTL3/IGF2BP2/IκBα axis participates in neuroinflammation in Alzheimer's disease by regulating M1/M2 polarization of microglia., PMID:40107503
Inhibition of METTL3 Attenuates Renal Fibrosis by Upregulating ABCG2 m6A Modifications via IGF2BP2-Dependent Mechanisms in Hyperuricemic Nephropathy., PMID:40100069
LINC02154 Promotes Esophageal Squamous Cell Carcinoma Progression via the PI3K-AKT-mTOR Signaling Pathway by Interacting With IGF2BP2., PMID:40099590
SMAD specific E3 ubiquitin protein ligase 1 accelerates diabetic macular edema progression by WNT inhibitory factor 1., PMID:40093288
The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression., PMID:40086519
Genetic variants of IGF2BP2 as potential predictors for perineural invasion of prostate cancer in a Taiwanese population., PMID:40084251
Inhibition of METTL3 promotes mesangial cell mitophagy and attenuates glomerular damage by alleviating FOSL1 m6A modifications via IGF2BP2-dependent mechanisms., PMID:40081768
For research use only. Not for human or drug use.
