Catalog No.
YHJ91401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala628-Val912
Predicted molecular weight
34.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6K1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dnmt3a, DNA MTase HsaIIIA, DNMT3A, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase HsaIIIA
The Association Between Clinical Outcome and Expression of DNMT1, 3A, and 3B in Locally Advanced Laryngeal Carcinomas Treated by Definitive Radiotherapy., PMID:40507223
Epigenetic Regulation of PEPT2 as a Novel Strategy to Improve the Antitumor Efficacy of Lenalidomide in Clear Cell Renal Cell Carcinoma., PMID:40504084
Staphylococcus aureus α-hemolysin induces DNA methylation changes in human Th1 cells., PMID:40498273
Polychlorinated Biphenyl-126 Activates AXL/ERb/DNMT3A Axis to Drive Endometriosis Progression., PMID:40470214
Regulatory mechanism of DNMT3A in interferon expression inhibition by Newcastle disease virus V protein., PMID:40456336
DNMT3A-dependent DNA methylation shapes the endothelial enhancer landscape., PMID:40444638
The effect of clonal hematopoiesis on long-term outcomes in patients undergoing coronary artery bypass grafting., PMID:40442635
GSK-3484862, a DNMT1 degrader, promotes DNMT3B expression in lung cancer cells., PMID:40433167
Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells., PMID:40427627
Rational Design and Synthesis of Highly Stable Haloflavanone DNA Methyltransferase Inhibitors Inducing Tumor Suppressor Gene Re-expression in Cancer Cells., PMID:40418195
Engineered Cas12a-based one-tube detection of DNMT3A R882 H/C mutation in acute myeloid leukemia., PMID:40413994
Genomic and transcriptomic determinants of clinical outcomes in patients with AML and DNMT3A mutations., PMID:40389402
[Dynamic changes in genetic mutations in myelodysplastic neoplasms with progressive disease and leukemic transformation]., PMID:40355355
Oncocytic subtype of well differentiated neuroendocrine tumor: clinicopathologic and molecular associations of a cohort diagnosed on fine needle aspiration (FNA)., PMID:40345926
Early-Life Adversity-Induced Epigenetic Reprogramming of Prefrontal Cortex in Rats Subjected to Maternal Separation., PMID:40342557
Hypermethylation of DNA impairs megakaryogenesis in delayed platelet recovery after allogeneic hematopoietic stem cell transplantation., PMID:40333970
Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis., PMID:40328830
DNMT3A facilitates breast cancer progression via regulating ADAMTS8 mediated EGFR-MEK-ERK activation., PMID:40323963
Cholesterol-conjugated miR-29b induces fetal haemoglobin expression via γ-globin promoter demethylation in the Townes mouse model for sickle cell anaemia., PMID:40320590
Generation of a homozygous DNMT3A knock-out hiPSC line for modeling of cardiovascular diseases associated with clonal hematopoiesis of indeterminate potential., PMID:40311329
NKX2-5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation., PMID:40307990
Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation., PMID:40307617
Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes., PMID:40305610
Clonal hematopoiesis of indeterminate potential and risk of immune thrombocytopenia., PMID:40302051
Allosteric Inhibitors of Cell-Cycle-Regulated Methyltransferase for Novel Antibiotic Development., PMID:40290972
Molecular predictors of venous and arterial thrombotic events in patients with myelofibrosis., PMID:40287867
Clinical-Genetic Approach to Conditions with Macrocephaly and ASD/Behaviour Abnormalities: Variants in PTEN and PPP2R5D Are the Most Recurrent Gene Mutations in a Patient-Oriented Diagnostic Strategy., PMID:40282429
Epigenetic silencing of SOD2 exacerbates mitochondrial oxidative stress and promotes pulmonary fibrosis., PMID:40280315
Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice., PMID:40279248
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells., PMID:40266434
Inferred clonal hematopoiesis from tumor DNA sequencing among men with prostate cancer: correlation with somatic tumor alterations and outcomes., PMID:40260993
Clinicopathological and prognostic significance of DDX41 mutation in myeloid neoplasms: a systematic review and meta-analysis., PMID:40257479
Impact of Clonal Hematopoiesis on Solid Tumor Progression Following Radiation Therapy., PMID:40249883
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis., PMID:40240771
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs., PMID:40240595
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis., PMID:40239706
Morphine Contributes to Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells by Blocking COX-2 Methylation via Regulating the miR-23a-3p/DNMT3A Feedback., PMID:40227561
Gene Mutation Characteristics and Prognostic Significance in Acute Myeloid Leukemia Patients From Northeast China., PMID:40226311
A significant correlation exists between CREBBP and CEBPA gene expression in de Novo adult acute myeloid leukemia., PMID:40216811
Association between clonal hematopoiesis and periodontitis: a two-sample mendelian randomization study., PMID:40204772
Impact of BCOR/BCORL1 mutation on outcomes of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients., PMID:40202539
Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia., PMID:40202536
The landscape of RNA 5-methylcytosine modification during chicken embryonic myogenesis., PMID:40188621
Coordinated regulation of chromatin modifiers reflects organised epigenetic programming in mouse oocytes., PMID:40186324
Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen., PMID:40178977
METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC-1α-MAPK Pathway and PGC-1α-Antioxidant System Axis., PMID:40171845
Clonal Evolution of PPM1D Mutations in the Spectrum of Myeloid Disorders., PMID:40162927
DNMT3A Stability Is Maintained by Ubiquitin-Specific Peptidase 11 (USP11) and Sumoylation Countering Degradation., PMID:40161590
A one-base therapeutic insertion in the HBG2 distal promoter reactivates γ-globin expression., PMID:40156013
Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase., PMID:40153459
For research use only. Not for human or drug use.
