Catalog No.
YHJ88401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr613-His842
Predicted molecular weight
28.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y4K4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KHS, MAPK/ERK kinase kinase kinase 5, MEKKK 5, Kinase homologous to SPS1/STE20, MAP4K5, Mitogen-activated protein kinase kinase kinase kinase 5, MEK kinase kinase 5
Mitogen-activated protein kinase signalling in rat hearts during postnatal development: MAPKs, MAP3Ks, MAP4Ks and DUSPs., PMID:39251052
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CLpro main protease (Mpro) from proteomic identification of P6-P6' active site specificity., PMID:38742901
Heterodimerization domains in MAP4 KINASEs determine subcellular localization and activity in Arabidopsis., PMID:38513700
MRCKα/β positively regulates Gli protein activity., PMID:37019250
Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition., PMID:36820830
STE20 phosphorylation of AMPK-related kinases revealed by biochemical purifications combined with genetics., PMID:35413284
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome., PMID:34672947
GCH1-regulated miRNAs are potential targets for microglial activation in neuropathic pain., PMID:34402860
An integrated DNA and RNA variant detector identifies a highly conserved three base exon in the MAP4K5 kinase locus., PMID:34190025
Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (MKK4) - A promising target for liver regeneration., PMID:33794385
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)., PMID:33199152
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach., PMID:33167727
Prognostic Value of mRNA Expression of MAP4K Family in Acute Myeloid Leukemia., PMID:31522654
[Effects of 0.5 Gy X-ray radiation on the profile of gene expression in MC3T3-E1 osteoblasts]., PMID:27666889
Prognostic and Functional Significance of MAP4K5 in Pancreatic Cancer., PMID:27023625
MAP4K Family Kinases in Immunity and Inflammation., PMID:26791862
Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells., PMID:26294741
Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis., PMID:25232032
Allelic and phenotypic spectrum of plasma triglycerides., PMID:22033228
Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA., PMID:17018633
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes., PMID:16914735
The -822G/A polymorphism in the promoter region of the MAP4K5 gene is associated with reduced risk of type 2 diabetes in Chinese Hans from Shanghai., PMID:16699725
Sex- and age-dependent human transcriptome variability: implications for chronic heart failure., PMID:12601168
Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2)., PMID:12591926
Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase., PMID:11384986
Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase GCKR promoting GCKR and SAPK activation., PMID:10648385
For research use only. Not for human or drug use.
