Catalog No.
YHJ86701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile256
Predicted molecular weight
31.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y2W7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A-type potassium channel modulatory protein 3, KCNIP3, DRE-antagonist modulator, KChIP3, KCHIP3, Calsenilin, DREAM, Kv channel-interacting protein 3, CSEN
Dissecting immune-mediated pathways in rheumatoid arthritis: A multivariate mediation analysis of antibodies and circulating proteins., PMID:40369022
p53 regulates DREAM complex-mediated repression in a p21-independent manner., PMID:40038454
Emerging Role of the DREAM Complex in Cancer and Therapeutic Opportunities., PMID:39796178
HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes., PMID:38789411
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence., PMID:38783095
Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer., PMID:37978395
Emerging Role of DREAM in Healthy Brain and Neurological Diseases., PMID:37298129
Blood Plasma Exosomes Contain Circulating DNA in Their Crown., PMID:35453902
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion., PMID:35131032
KCNIP3 silence promotes proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma through activating Wnt/β-catenin pathway., PMID:35066335
Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation., PMID:34751735
Simultaneous expression of MMB-FOXM1 complex components enables efficient bypass of senescence., PMID:34728711
Progesterone Receptors Promote Quiescence and Ovarian Cancer Cell Phenotypes via DREAM in p53-Mutant Fallopian Tube Models., PMID:33755733
PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis., PMID:33626321
Benzo[a]pyrene represses DNA repair through altered E2F1/E2F4 function marking an early event in DNA damage-induced cellular senescence., PMID:33166399
Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats., PMID:32671697
Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3., PMID:32641494
HDAC4 and HDAC5 form a complex with DREAM that epigenetically down-regulates NCX3 gene and its pharmacological inhibition reduces neuronal stroke damage., PMID:31696766
Molecular profiling predicts meningioma recurrence and reveals loss of DREAM complex repression in aggressive tumors., PMID:31591222
DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation., PMID:31400114
Proteomic Profile of a Chronic Binge Ethanol Exposure Model., PMID:31329447
Targeting the neuronal calcium sensor DREAM with small-molecules for Huntington's disease treatment., PMID:31086218
Cyclin D-CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB., PMID:30833638
Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats., PMID:30740043
Resveratrol treatment reduces the vulnerability of SH-SY5Y cells and cortical neurons overexpressing SOD1-G93A to Thimerosal toxicity through SIRT1/DREAM/PDYN pathway., PMID:30503815
TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets., PMID:30451831
KChIP3 coupled to Ca2+ oscillations exerts a tonic brake on baseline mucin release in the colon., PMID:30272559
The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb., PMID:30206359
Diagnostic utility of DREAM gene mRNA levels in thyroid tumours., PMID:29641740
Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening., PMID:29581270
CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition., PMID:29514186
KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats., PMID:29335353
[DREAM: a multifunctional transcriptional regulator]., PMID:29063118
The function of DREAM gene mediated by NF-kB signal pathway in the pathogenesis of osteosarcoma., PMID:28952229
Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus., PMID:28946006
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression., PMID:28806394
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes., PMID:28799433
Nicotine-prevented learning and memory impairment in REM sleep-deprived rat is modulated by DREAM protein in the hippocampus., PMID:28638710
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM)., PMID:28627884
Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway., PMID:28572607
A Systematic Analysis of Negative Growth Control Implicates the DREAM Complex in Cancer Cell Dormancy., PMID:28031411
Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks., PMID:27280975
Expression of PAX8 Target Genes in Papillary Thyroid Carcinoma., PMID:27249794
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease., PMID:26752648
Proteome-wide Identification of Novel Ceramide-binding Proteins by Yeast Surface cDNA Display and Deep Sequencing., PMID:26729710
The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes., PMID:26384566
Evaluation of Downstream Regulatory Element Antagonistic Modulator Gene in Human Multinodular Goiter., PMID:26319784
A B-myb--DREAM complex is not critical to regulate the G2/M genes in HPV-transformed cell lines., PMID:25368258
REM sleep deprivation induces changes of down regulatory antagonist modulator (DREAM) expression in the ventrobasal thalamic nuclei of sprague-dawley rats., PMID:25218926
Towards a better understanding of cognitive behaviors regulated by gene expression downstream of activity-dependent transcription factors., PMID:25173698
For research use only. Not for human or drug use.
