Catalog No.
YHJ84001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe714-His981
Predicted molecular weight
31.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y219
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein jagged-2, hJ2, Jagged2, JAG2
JAG2 AS A KEY MEDIATOR IN PORPHYROMONAS GINGIVALIS-INDUCED PERIODONTAL INFLAMMATION., PMID:40466700
JAG2: A Potential Biomarker for Microtia Identified by Integrated RNA Transcriptome Analysis., PMID:40433419
Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells., PMID:40120139
CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling., PMID:40032820
Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases., PMID:39985304
Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2., PMID:39904982
Diversity in Notch ligand-receptor signaling interactions., PMID:39751380
Mll4 in skeletal muscle fibers maintains muscle stem cells., PMID:39710699
Case Report: Exploring the clinical spectrum of LGMD R27: insights from a case study with homozygous pathogenic variant in the JAG2 gene., PMID:39649397
The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation., PMID:39585329
Three novel missense variants in two families with JAG2-associated limb-girdle muscular dystrophy., PMID:39121631
Predicting regulatory mutations and their target genes by new computational integrative analysis: A study of follicular lymphoma., PMID:38901187
Rho kinase inhibitor Y-27632 downregulates IL-1β expression in mice with experimental autoimmune myocarditis., PMID:38684719
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522
Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells., PMID:38575576
ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway., PMID:38485033
miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells., PMID:38395762
TRIP6 a potential diagnostic marker for colorectal cancer with glycolysis and immune infiltration association., PMID:38369589
Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling., PMID:38277398
The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7., PMID:38195542
Optimization of a Three-Dimensional Culturing Method for Assessing the Impact of Cisplatin on Notch Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)., PMID:38001580
Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis., PMID:37966490
The Potential of JAG Ligands as Therapeutic Targets and Predictive Biomarkers in Multiple Myeloma., PMID:37834003
NOTCH Pathway Genes in Ovarian Cancer: Clinical Significance and Associations with Immune Cell Infiltration., PMID:37796700
Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367
SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100., PMID:37582765
An investigation into the role of Notch signaling, altered angiogenesis, and inflammatory-induced preterm delivery and related complications in Northeast Indian patients., PMID:37421871
Jagged/Notch proteins promote endothelial-mesenchymal transition-mediated pulmonary arterial hypertension via upregulation of the expression of GATAs., PMID:36942326
Characterization of Histone Modifications in Late-Stage Rotator Cuff Tendinopathy., PMID:36833423
MicroRNA-381 Regulates Proliferation and Differentiation of Caprine Skeletal Muscle Satellite Cells by Targeting PTEN and JAG2., PMID:36362373
B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding., PMID:36323228
Effects of mRNA expression of five Notch ligands on prognosis of gastric carcinoma., PMID:36071128
The Notch signaling pathway in skeletal muscle health and disease., PMID:35968817
Assemblies of JAG1 and JAG2 determine tracheobronchial cell fate in mucosecretory lung disease., PMID:35819850
Dietary High Dose of Iron Aggravates the Intestinal Injury but Promotes Intestinal Regeneration by Regulating Intestinal Stem Cells Activity in Adult Mice With Dextran Sodium Sulfate-Induced Colitis., PMID:35782573
Altered expression of Notch signaling, Tlr receptors, and surfactant protein expression after prostaglandin inhibition may be associated with the delayed labor in LPS-induced mice., PMID:35538257
miR-2392 functions as tumour suppressor and inhibits malignant progression of hepatocellular carcinoma via directly targeting JAG2., PMID:35485355
Anti-Jagged-1 immunotherapy in cancer., PMID:35421813
Involvement of muscle satellite cell dysfunction in neuromuscular disorders: Expanding the portfolio of satellite cell-opathies., PMID:35302338
TMEM8C-mediated fusion is regionalized and regulated by NOTCH signalling during foetal myogenesis., PMID:35005776
Relationship of Notch Signal, Surfactant Protein A, and Indomethacin in Cervix During Preterm Birth: Mast Cell and Jagged-2 May Be Key in Understanding Infection-mediated Preterm Birth., PMID:34927491
[JAG2-related muscular dystrophy: When differential diagnosis matters]., PMID:34878394
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension., PMID:34669509
Release of Notch activity coordinated by IL-1β signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration., PMID:34475534
Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse., PMID:34438113
Epigenomic landscape and 3D genome structure in pediatric high-grade glioma., PMID:34078608
A form of muscular dystrophy associated with pathogenic variants in JAG2., PMID:33861953
Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway., PMID:33781349
Evaluation of testicular toxicity upon fetal exposure to bisphenol A using an organ culture method., PMID:33421752
Identifying specific Notch1 target proteins in lung carcinoma cells., PMID:33094831
For research use only. Not for human or drug use.
