Catalog No.
YHJ83501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu995-Glu1181
Predicted molecular weight
23.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UQE7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BMH, CSPG6, SMC protein 3, Basement membrane-associated chondroitin proteoglycan, SMC3, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, BAM, hCAP, Bamacan, Structural maintenance of chromosomes protein 3, SMC3L1, SMC-3
Analysis of Combinatorial Cohesin Subunit Gene Deletions in Budding Yeast., PMID:40492837
Protein turnover downstream of the Nipbl/CRL4 axis contributes to abnormal development in zebrafish embryos., PMID:40396618
Deletion of Nrf1α exacerbates oxidative stress-induced cellular senescence by disrupting cell homeostasis., PMID:40280334
Characteristics and clinical outcomes of patients with myeloid malignancies and cohesin mutations., PMID:40219906
Molecular dynamics simulations of human cohesin subunits identify DNA binding sites and their potential roles in DNA loop extrusion., PMID:40184420
Studies on the regulation of E3 ubiquitin ligase APC3 and its interacting proteins on the tetraspore formation and release in Gracilariopsis lemaneiformis (Rhodophyta)., PMID:40169068
Chemoproteomic Profiling of PKA Substrates with Kinase-catalyzed Crosslinking and Immunoprecipitation (K-CLIP)., PMID:40166339
Cohesin and condensin regulate chromosome topology and play an essential role in maintaining pluripotency in embryonic stem cells., PMID:40121293
Cohesin mutations and chromatin changes in cancer., PMID:40063003
Analysis and identification of potential biomarkers for dysfunctional uterine bleeding., PMID:39862473
B Chromosome Transcriptional Inactivation in the Spermatogenesis of the Grasshopper Eyprepocnemis plorans., PMID:39766780
Predicting CTCF cell type active binding sites in human genome., PMID:39738353
Genome Instability and Senescence Are Markers of Cornelia de Lange Syndrome Cells., PMID:39682772
Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development., PMID:39627609
Prediction of YY1 loop anchor based on multi-omics features., PMID:39521361
Combined HDAC8 and checkpoint kinase inhibition induces tumor-selective synthetic lethality in preclinical models., PMID:39436709
HDAC8 as a target in drug discovery: Function, structure and design., PMID:39427514
Cohesin ring gates are specialized for meiotic cell division., PMID:39401990
A Novel De Novo STAG1 Variant in Monozygotic Twins with Neurodevelopmental Disorder: New Insights in Clinical Heterogeneity., PMID:39336775
ZNF521 promotes acute myeloid leukemogenesis by suppressing the expression and acetylation of SMC3., PMID:39309877
Untangling the loops of STAG2 mutations in myelodysplastic syndrome., PMID:39264305
Cohesin mutations in acute myeloid leukemia., PMID:39251741
The cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains., PMID:39240714
A novel STAG1 variant associated with congenital clubfoot and microphthalmia: A case report., PMID:39224759
Assessment of NB-UVB Effects on Skin of Atopic Dermatitis Patients: A Network Analysis., PMID:39188927
RetSat stabilizes mitotic chromosome segregation in pluripotent stem cells., PMID:39172275
Molecular mechanism and functional significance of Wapl interaction with the Cohesin complex., PMID:39110738
Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid Tumors., PMID:39089850
SMC3 contributes to heart development by regulating super-enhancer associated genes., PMID:39085358
Reversible acetylation of HDAC8 regulates cell cycle., PMID:39043961
Subunit-specific analysis of cohesin-mutant myeloid malignancies reveals distinct ontogeny and outcomes., PMID:39033241
Cohesin composition and dosage independently affect early development in zebrafish., PMID:38975838
Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8., PMID:38949959
Chromatin-associated cohesin turns over extensively and forms new cohesive linkages in Drosophila oocytes during meiotic prophase., PMID:38870933
Cornelia de Lange Spectrum., PMID:38735830
Identification of two novel heterozygous variants of SMC3 with Cornelia de Lange syndrome., PMID:38733165
Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts., PMID:38607047
Yin Yang 1 regulates cohesin complex protein SMC3 in mouse hematopoietic stem cells., PMID:38531064
New candidate genes potentially involved in Zika virus teratogenesis., PMID:38522248
Comparative study on chromatin loop callers using Hi-C data reveals their effectiveness., PMID:38515011
Genetic determinants of micronucleus formation in vivo., PMID:38355793
[Genetic analysis of a fetus with Cornelia de Lange syndrome due to variant of SMC3 gene]., PMID:38311569
Heterozygous loss-of-function SMC3 variants are associated with variable growth and developmental features., PMID:38297832
Systematic identification of key basement membrane related genes as potential new biomarkers in Alzheimer's disease., PMID:38154381
RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma., PMID:38017479
What AlphaFold tells us about cohesin's retention on and release from chromosomes., PMID:37975572
XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes., PMID:37939182
Mechanical disengagement of the cohesin ring., PMID:37872232
High-speed AFM imaging reveals DNA capture and loop extrusion dynamics by cohesin-NIPBL., PMID:37774974
Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding., PMID:37739959
For research use only. Not for human or drug use.
