Catalog No.
YHJ78401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser320-Arg429
Predicted molecular weight
14.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UK05
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GDF2, BMP-9, Growth/differentiation factor 2, Bone morphogenetic protein 9, GDF-2, BMP9
Unprocessed BMP9 precursor is an intrinsic antagonist for its active growth factor., PMID:40412377
Distinct signalling dynamics of BMP4 and BMP9 in brown versus white adipocytes., PMID:40335635
Synergistic influences of BMP9 and NGF on the osteogenic differentiation of C3H10T1/2 mesenchymal stem cells., PMID:40089726
Ineffectiveness of Sotatercept Therapy in a Patient With Heritable Pulmonary Arterial Hypertension Associated With a Previously Unreported Missense Variant in GDF2, the Gene for Bone Morphogenic Protein-9., PMID:39939060
BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework., PMID:39935787
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome., PMID:39858399
Thermoresponsive dual-network chitosan-based hydrogels with demineralized bone matrix for controlled release of rhBMP9 in the treatment of femoral head osteonecrosis., PMID:39843099
Molecular Basis of Interchain Disulfide Bond Formation in BMP-9 and BMP-10., PMID:39793884
Hereditary haemorrhagic telangiectasia., PMID:39788978
Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells., PMID:39718997
The regulatory role of BMP9 on lipopolysaccharide-induced matrix metalloproteinases in human stem cells from the apical papilla., PMID:39689436
BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signaling., PMID:39627568
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health., PMID:39453386
Hypoxia-induced TIMAP upregulation in endothelial cells and TIMAP-dependent tumor angiogenesis., PMID:39344413
DDIT3 switches osteogenic potential of BMP9 to lipogenic by attenuating Wnt/β-catenin signaling via up-regulating DKK1 in mesenchymal stem cells., PMID:39331002
Bone Morphogenetic Protein 9 Protects Against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics., PMID:39315433
Evolution and Comparative Genomics of the Transforming Growth Factor-β-Related Proteins in Nile Tilapia., PMID:39240458
Unveiling the Impact of BMP9 in Liver Diseases: Insights into Pathogenesis and Therapeutic Potential., PMID:39199400
Molecular mechanisms and clinical manifestations of hereditary hemorrhagic telangiectasia., PMID:39151291
Effects of Modulating BMP9, BMPR2, and AQP1 on BMP Signaling in Human Pulmonary Microvascular Endothelial Cells., PMID:39125626
Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation., PMID:38979789
DLX6-AS1 regulates odonto/osteogenic differentiation in dental pulp cells under the control of BMP9 via the miR-128-3p/MAPK14 axis: A laboratory investigation., PMID:38973098
Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney injury through inhibition of renal VEGFA., PMID:38885771
SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells., PMID:38795838
Pulmonary vascular phenotype identified in patients with GDF2 (BMP9) or BMP10 variants: an international multicentre study., PMID:38514094
BMP9 is a key player in endothelial identity and its loss is sufficient to induce arteriovenous malformations., PMID:38502919
Circulating Bone morphogenetic protein 9 (BMP9) as a new biomarker for noninvasive stratification of nonalcoholic fatty liver disease and metabolic syndrome., PMID:38492130
Hemodynamic and Clinical Profiles of Pulmonary Arterial Hypertension Patients with GDF2 and BMPR2 Variants., PMID:38473983
Comparative genomic studies on the TGF-β superfamily in blue whale., PMID:38467865
Novel role of bone morphogenetic protein 9 in innate host responses to HCMV infection., PMID:38308064
Bone morphogenetic protein-9 downregulates StAR expression by inducing snail expression via SMAD1/5/8 signaling in human granulosa-lutein cells., PMID:38109991
Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells., PMID:38031108
Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module., PMID:37972658
BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells., PMID:37894931
MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts., PMID:37802385
New genetic drivers in hemorrhagic hereditary telangiectasia., PMID:37689549
Effect of the secretome of mesenchymal stem cells overexpressing BMP-9 on osteoblast differentiation and bone repair., PMID:37661654
Early induction of Hes1 by bone morphogenetic protein 9 plays a regulatory role in osteoblastic differentiation of a mesenchymal stem cell line., PMID:37565579
BMP9 functions as a negative regulator in the myogenic differentiation of primary mouse myoblasts., PMID:37553201
BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway., PMID:37550619
Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches?, PMID:37461888
Defining the clinical validity of genes reported to cause pulmonary arterial hypertension., PMID:37422716
Bone Morphogenic Protein 9 (BMP9)/Growth Differentiation Factor 2 (GDF2) modulates mouse adult hippocampal neurogenesis by regulating the survival of early neural progenitors., PMID:37397531
Pediatric pulmonary arterial hypertension due to a novel homozygous GDF2 missense variant affecting BMP9 processing and activity., PMID:37249087
Endothelial tip/stalk cell selection requires BMP9-induced βIV-spectrin expression during sprouting angiogenesis., PMID:37126382
Intestinal BMP-9 locally upregulates FGF19 and is down-regulated in obese patients with diabetes., PMID:37085108
[Hereditary hemorrhagic telangiectasia]., PMID:37062633
BMP9 promotes autophagy and inhibits migration and invasion in breast cancer cells through the c-Myc/SNHG3/mTOR signaling axis., PMID:36963166
A GDF2 missense mutation potentially involved in the pathogenesis of hereditary hemorrhagic telangiectasia: a case report., PMID:36891821
Hereditary Hemorrhagic Telangiectasia in Pediatric Age: Focus on Genetics and Diagnosis., PMID:36810341
For research use only. Not for human or drug use.
