Catalog No.
YHJ73601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln107-His212
Predicted molecular weight
14.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBT3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DKK4, hDkk-4, Dkk-4, Dickkopf-4, Dickkopf-related protein 4
Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma., PMID:39851951
Correlation and Prediction of IL-10Ra and DKK-4 Plasma Levels in Patients with Calcium Oxalate Urolithiasis., PMID:39506574
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation., PMID:39166492
Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis., PMID:39026176
First Transcriptome Analysis of Hepatoblastoma in Brazil: Unraveling the Pivotal Role of Noncoding RNAs and Metabolic Pathways., PMID:38649558
Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Pelodiscus sinensis)., PMID:38540029
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis., PMID:38519641
Role of Sox3 in Estradiol-Induced Sex Reversal in Pelodiscus sinensis., PMID:38203425
The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer., PMID:38201279
Molecular Evolution and Protein Structure Variation of Dkk Family., PMID:37895211
O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/β-catenin signalling., PMID:37070251
Wnt signaling modulator DKK4 inhibits colorectal cancer metastasis through an AKT/Wnt/β-catenin negative feedback pathway., PMID:36181792
Proteomic biomarkers of Kleine-Levin syndrome., PMID:35859339
HCV Core protein represses DKK3 expression via epigenetic silencing and activates the Wnt/β-catenin signaling pathway during the progression of HCC., PMID:35768685
Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer., PMID:35101137
Distinguishing colorectal adenoma from hyperplastic polyp by WNT2 expression., PMID:34477243
Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression., PMID:34255218
Mining the 99 Lives Cat Genome Sequencing Consortium database implicates genes and variants for the Ticked locus in domestic cats (Felis catus)., PMID:33780570
A literature review on function and regulation mechanism of DKK4., PMID:33586359
Development and Maintenance of Epidermal Stem Cells in Skin Adnexa., PMID:33419358
Methylation Assessment of Two DKK2 and DKK4 Genes in Oral Squamous Cell Carcinoma Patients., PMID:33346226
The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma., PMID:33281184
Expression profiles of the Wnt/β-catenin signaling-related extracellular antagonists during proliferation and differentiation in human osteoblast-like cells., PMID:33178352
Proteomics Study on the Differentially Expressed Proteins in c-fos-silenced Cells Exposed to PM 2.5., PMID:33106213
Sensitization of hepatocellular carcinoma cells towards doxorubicin and sorafenib is facilitated by glucosedependent alterations in reactive oxygen species, P-glycoprotein and DKK4., PMID:32713860
DKK3 expression and function in head and neck squamous cell carcinoma and other cancers., PMID:32032750
Dickkopf-4 gene expression is associated with differentiation and lymph node metastasis in colorectal cancer., PMID:31633047
Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor., PMID:31353847
DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4., PMID:31202458
A novel high-content imaging-based technique for measuring binding of Dickkopf-1 to low-density lipoprotein receptor-related protein 6., PMID:30476623
Dkk1 involvement and its potential as a biomarker in pancreatic ductal adenocarcinoma., PMID:30452897
Genetic Variants in the Wingless Antagonist Genes (sFRP, DKK, and Axin2) Predict the Overall Survival and Prognosis of North Indian Lung Cancer Patients Treated with Platinum-Based Doublet Chemotherapy., PMID:30346805
In silico studying of the whole protein structure and dynamics of Dickkopf family members showed that N-terminal domain of Dickkopf 2 in contrary to other Dickkopfs facilitates its interaction with low density lipoprotein receptor related protein 5/6., PMID:30035709
Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins., PMID:29925589
Role of DKK4 in Tumorigenesis and Tumor Progression., PMID:29904276
High-order gene interactions between the genetic polymorphisms in Wnt and AhR pathway in modulating lung cancer susceptibility., PMID:29749862
Identification, isolation and characterization of human LGR5-positive colon adenoma cells., PMID:29467240
The key role of proinflammatory cytokines, matrix proteins, RANKL/OPG and Wnt/β-catenin in bone healing of hip arthroplasty patients., PMID:29129760
DKK4-knockdown enhances chemosensitivity of A549/DTX cells to docetaxel., PMID:28981599
Dickkopf-4 is frequently overexpressed in epithelial ovarian carcinoma and promotes tumor invasion., PMID:28666421
Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor., PMID:28611108
TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells., PMID:28450117
LncRNA-H19 Modulates Wnt/β-catenin Signaling by Targeting Dkk4 in Hindlimb Unloaded Rat., PMID:28447380
Plasma cytokine profiling to predict susceptibility to acute mountain sickness., PMID:28396299
DKK4 enhances resistance to chemotherapeutics 5-Fu and YN968D1 in colorectal cancer cells., PMID:28356933
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer., PMID:28273073
CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells., PMID:28229932
Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development., PMID:27864382
Association of polymorphisms in Dickopff (DKK) gene towards modulating risk for lung cancer in north Indians., PMID:27640551
Multilayer OMIC Data in Medullary Thyroid Carcinoma Identifies the STAT3 Pathway as a Potential Therapeutic Target in RETM918T Tumors., PMID:27620278
For research use only. Not for human or drug use.
