Catalog No.
YHJ72601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu28-Phe225
Predicted molecular weight
24.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBD9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CLCF1, Cardiotrophin-like cytokine factor 1, NNT1, CLC, B-cell-stimulating factor 3, NNT-1, Novel neurotrophin-1, BSF3, BSF-3
Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice., PMID:40399268
High-yield production of recombinant CLCF1 protein fused with human serum albumin in animal cells and toxicity evaluation in rodents., PMID:40393625
MAFF alleviates hepatic ischemia-reperfusion injury by regulating the CLCF1/STAT3 signaling pathway., PMID:40169936
Regulation of macrophage efferocytosis by the CLCF1/NF-κB pathway improves neurological and cognitive impairment following CO poisoning., PMID:40081779
CRLF1/CLCF1 heterodimer involvement in intervertebral disc degeneration via exacerbation of extracellular matrix degradation and nucleus pulposus cell senescence., PMID:39986601
Chromatin accessibility and differentially expressed genes profiling in large yellow croaker (Larimichthys crocea) head kidney cells following iridovirus infection., PMID:39949772
A novel immune-related gene prognostic signature combining immune cell infiltration and immune checkpoint for glioblastoma patients., PMID:39697704
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Evaluating the IL-6 Family of Cytokines Throughout Equine Gestation., PMID:39072818
Detection of CLCF1 protein expression by flow cytometry., PMID:38858477
Reduced serum CLCF1 levels in hyperthyroidism patients and T3-treated mice., PMID:38842921
Cytokine Receptor-like Factor 1 (CRLF1) and Its Role in Osteochondral Repair., PMID:38727293
Interleukin-6 Family of Cytokines in Cancers., PMID:38232478
CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis., PMID:38190531
New perspectives in cancer immunotherapy: targeting IL-6 cytokine family., PMID:37945321
Mucosal expression of PI3, ANXA1, and VDR discriminates Crohn's disease from ulcerative colitis., PMID:37891214
CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes., PMID:37549287
What is circulating factor disease and how is it currently explained?, PMID:36952039
Structural insights into the assembly of gp130 family cytokine signaling complexes., PMID:36930708
CNTF induces Clcf1 in astrocytes to promote the differentiation of oligodendrocyte precursor cells., PMID:36334441
Uncovering the promiscuous activity of IL-6 proteins: A multi-dimensional analysis of phylogeny, classification and residue conservation., PMID:36222303
Editorial: Cytokine and cytokine receptor-based immunotherapies: Updates, controversies, challenges, and future perspectives., PMID:35958607
Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice., PMID:35950514
Clinical and molecular genetic findings of Crisponi/cold-induced sweating syndrome (CS/CISS) spectrum in patients from Turkey., PMID:35699517
Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction., PMID:35618347
Bromodomain-containing protein 4 activates cardiotrophin-like cytokine factor 1, an unfavorable prognostic biomarker, and promotes glioblastoma in vitro., PMID:35571403
CLCF1 Is a Novel Potential Immune-Related Target With Predictive Value for Prognosis and Immunotherapy Response in Glioma., PMID:35265072
CRLF1 and CLCF1 in Development, Health and Disease., PMID:35055176
Specific cytokines of interleukin-6 family interact with S100 proteins., PMID:34933172
Serum levels of plasminogen activator urokinase receptor and cardiotrophin-like cytokine factor 1 in patients with nephrotic syndrome., PMID:34779387
Cardiotrophin Like Cytokine Factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway., PMID:34364014
Influences of the IL-6 cytokine family on bone structure and function., PMID:34332274
Regulation of Osteoblast Differentiation by Cytokine Networks., PMID:33799644
Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression., PMID:33682185
Cancer-Associated Fibroblasts: Orchestrating the Crosstalk Between Liver Cancer Cells and Neutrophils Through the Cardiotrophin-Like Cytokine Factor 1-Mediated Chemokine (C-X-C motif) Ligand 6/TGF-β Axis., PMID:33639004
Association of cardiotrophin-like cytokine factor 1 levels in peripheral blood mononuclear cells with bone mineral density and osteoporosis in postmenopausal women., PMID:33430863
Update on Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplantation., PMID:33260184
Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts., PMID:32626662
Engineering a potent receptor superagonist or antagonist from a novel IL-6 family cytokine ligand., PMID:32522868
Crisponi syndrome/cold-induced sweating syndrome type 2: Reprogramming of CS/CISS2 individual derived fibroblasts into three clones of one iPSC line., PMID:32512309
Antitumor activity of an engineered decoy receptor targeting CLCF1-CNTFR signaling in lung adenocarcinoma., PMID:31700175
Cardiotrophin-Like Cytokine Factor 1 Exhibits a Myeloid-Biased Hematopoietic-Stimulating Function., PMID:31552057
Crisponi/cold-induced sweating syndrome: Differential diagnosis, pathogenesis and treatment concepts., PMID:31497877
Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels., PMID:31483567
Cardiotrophin-like cytokine (CLCF1) modulates mesenchymal stem cell osteoblastic differentiation., PMID:31248987
Leukemia inhibitory factor signaling in Xenopus embryo: Insights from gain of function analysis and dominant negative mutant of the receptor., PMID:30578761
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer., PMID:30254251
Cardiotrophin-like Cytokine Increases Macrophage-Foam Cell Transition., PMID:30209193
Protecting Podocytes: A Key Target for Therapy of Focal Segmental Glomerulosclerosis., PMID:29852493
Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity., PMID:29507344
For research use only. Not for human or drug use.
