Catalog No.
YHJ72301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys781-Gln1043
Predicted molecular weight
31.36 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBC5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MIHC, MYO1A, Unconventional myosin-Ia, BBMI, MYHL, Brush border myosin I, Myosin I heavy chain, BBM-I
The Genetic Architecture of Congenital Diarrhea and Enteropathy., PMID:40174224
Down-regulation of MYO1A inhibits trophoblast cell proliferation and migration through SMURF2/Hedgehog signaling pathway and leads to fetal growth restriction., PMID:40147359
Transcriptomic analysis of broiler chickens reveals metabolic adaptations to a reduced crude protein diet., PMID:39983527
Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human., PMID:39802512
Gut microbiota promotes pain chronicity in Myosin1A deficient male mice., PMID:38710336
Exome sequencing identifies HELB as a novel susceptibility gene for non-mucinous, non-high-grade-serous epithelial ovarian cancer., PMID:38633804
Identification of potential biomarkers in Barrett's esophagus derived esophageal adenocarcinoma., PMID:36759514
Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma., PMID:32998690
Dictyostelium myosin 1F and myosin 1E inhibit actin waves in a lipid-binding-dependent and motor-independent manner., PMID:32734648
Development and Validation of a Prognostic Nomogram for Gastric Cancer Based on DNA Methylation-Driven Differentially Expressed Genes., PMID:32174791
Basic-hydrophobic sites are localized in conserved positions inside and outside of PH domains and affect localization of Dictyostelium myosin 1s., PMID:31774725
Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport., PMID:31620669
Identification of targeting peptides for the diagnosis of myocarditis., PMID:29473787
A genotypic ascertainment approach to refute the association of MYO1A variants with non-syndromic deafness., PMID:27759032
Selective localization of myosin-I proteins in macropinosomes and actin waves., PMID:26801966
Variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A are associated with intermediate Charcot-Marie-Tooth disease in a Norwegian family., PMID:26517670
Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI., PMID:26286357
Analysis of Low Frequency Protein Truncating Stop-Codon Variants and Fasting Concentration of Growth Hormone., PMID:26086970
Targeted Exome Sequencing of Deafness Genes After Failure of Auditory Phenotype-Driven Candidate Gene Screening., PMID:25830873
Shaping the intestinal brush border., PMID:25422372
The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss., PMID:25080041
Targeted and genomewide NGS data disqualify mutations in MYO1A, the "DFNA48 gene", as a cause of deafness., PMID:24616153
Motor and tail homology 1 (Th1) domains antagonistically control myosin-1 dynamics., PMID:24507605
Brush border myosin Ia inactivation in gastric but not endometrial tumors., PMID:23002058
Myopodin isoforms alter the chemokinetic response of PC3 cells in response to different migration stimuli via differential effects on Rho-ROCK signaling pathways., PMID:22915763
Membrane-bound myo1c powers asymmetric motility of actin filaments., PMID:22863317
Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine., PMID:22510086
Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions., PMID:22386311
Myosin-1A targets to microvilli using multiple membrane binding motifs in the tail homology 1 (TH1) domain., PMID:22367206
Myosin heavy chain composition of the human genioglossus muscle., PMID:22337492
Brush border myosin Ia has tumor suppressor activity in the intestine., PMID:22307608
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins., PMID:22114352
Molecular model of the microvillar cytoskeleton and organization of the brush border., PMID:20195380
Differential localization and dynamics of class I myosins in the enterocyte microvillus., PMID:20089841
Control of cell membrane tension by myosin-I., PMID:19574460
The enterocyte microvillus is a vesicle-generating organelle., PMID:19564407
A novel form of motility in filopodia revealed by imaging myosin-X at the single-molecule level., PMID:19398338
A novel nonsense mutation in MYO6 is associated with progressive nonsyndromic hearing loss in a Danish DFNA22 family., PMID:18348273
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a., PMID:17981900
Myosin-1a powers the sliding of apical membrane along microvillar actin bundles., PMID:17502425
Myosin-1a is critical for normal brush border structure and composition., PMID:15758024
A two-photon FRAP analysis of the cytoskeleton dynamics in the microvilli of intestinal cells., PMID:15596489
A role for myosin-1A in the localization of a brush border disaccharidase., PMID:15138292
Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss., PMID:12736868
Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia., PMID:12486594
MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells., PMID:11916846
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells., PMID:11853671
Fission yeast myosin-I, Myo1p, stimulates actin assembly by Arp2/3 complex and shares functions with WASp., PMID:11076964
Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes., PMID:10653589
For research use only. Not for human or drug use.
