Catalog No.
YHJ72201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser100
Predicted molecular weight
13.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBC3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB, DNMT3B
Uncovering a Novel Role of ROR1 in the Epigenetic Regulation of Tumor Suppressor Gene CREB3L1 in Triple-Negative Breast Cancer Cells., PMID:40427627
Isothiocyanates Enhance the Anti-Melanoma Effect of Zebularine Through Modulation of Apoptosis and Regulation of DNMTs' Expression, Chromatin Configuration and Histone Posttranslational Modifications Associated with Altered Gene Expression Patterns., PMID:40136320
Mild traumatic brain injury increases vulnerability to post-traumatic stress disorder in rats and the possible role of hippocampal DNA methylation., PMID:40099224
SOX7 inhibits the malignant progression of bladder cancer via the DNMT3B/CYGB axis., PMID:39227479
DNA methylation of miR-181a-5p mediated by DNMT3b drives renal interstitial fibrosis developed from acute kidney injury., PMID:39023272
Isorhapontigenin inhibition of basal muscle-invasive bladder cancer attributed to its downregulation of SNHG1 and DNMT3b., PMID:38879516
DNMT3B splicing dysregulation mediated by SMCHD1 loss contributes to DUX4 overexpression and FSHD pathogenesis., PMID:38809976
Rhein suppresses esophageal cancer development by regulating cell cycle through DNMT3B gene., PMID:38743323
Inhibiting DNA methyltransferase DNMT3B confers protection against ferroptosis in nucleus pulposus and ameliorates intervertebral disc degeneration via upregulating SLC40A1., PMID:38705495
Dnmt3b ablation affects fracture repair process by regulating apoptosis., PMID:38413962
The interaction of RELN-DNMT genes involving in neurotrophin signaling pathway contributes to schizophrenia susceptibility., PMID:38296839
Structural basis for the allosteric regulation and dynamic assembly of DNMT3B., PMID:37941146
An updated meta-analysis investigating the association between DNMTs gene polymorphism andgastric cancer risk., PMID:37878642
DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression., PMID:37703946
ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation., PMID:37480691
Porcine Epidemic Diarrhea Virus nsp13 Protein Downregulates Neonatal Fc Receptor Expression by Causing Promoter Hypermethylation through the NF-κB Signaling Pathway., PMID:36602596
Circ_0000467 modulates malignant characteristics of colorectal cancer via sponging miR-651-5p and up-regulating DNMT3B., PMID:36067529
Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease., PMID:34944751
DNMT3B regulates proliferation of A549 cells through the microRNA-152-3p/NCAM1 pathway., PMID:34820010
Increased de novo DNA Methylation Enzymes in Sperm of Individuals with Varicocele., PMID:34455713
[Relationship of DNMT3b expression and SEPT9 methylation in theprogression of colorectal carcinogenesis]., PMID:33256303
Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice., PMID:33004076
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis]., PMID:32990224
EGCG Attenuates Renal Damage via Reversing Klotho Hypermethylation in Diabetic db/db Mice and HK-2 Cells., PMID:32908633
Goat DNMT3B: An indel mutation detection, association analysis with litter size and mRNA expression in gonads., PMID:32122684
Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart., PMID:31936461
miR‑29 promoter and enhancer methylation identified by pyrosequencing in Burkitt lymhoma cells: Interplay between MYC and miR‑29 regulation., PMID:31173259
Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis., PMID:29955086
Methamphetamine alters DNMT and HDAC activity in the posterior dorsal medial amygdala in an ovarian steroid-dependent manner., PMID:29944893
miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway., PMID:29796115
Superovulation alters DNA methyltransferase protein expression in mouse oocytes and early embryos., PMID:29164502
miR-6539 is a novel mediator of somatic cell reprogramming that represses the translation of Dnmt3b., PMID:28603220
Effects of bufalin on up-regulating methylation of Wilm's tumor 1 gene in human erythroid leukemic cells., PMID:28364352
Corrigendum to "An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection" [Cancer Lett. 226 (1) (2005 Aug 8) 77-84]., PMID:28038969
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation., PMID:27764816
A Novel Mutation in a Critical Region for the Methyl Donor Binding in DNMT3B Causes Immunodeficiency, Centromeric Instability, and Facial Anomalies Syndrome (ICF)., PMID:27734333
Genome-wide methylation analysis of DNMT3B gene isoforms revealed specific methylation profiles in breast cell lines., PMID:27586997
The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent., PMID:27449289
Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation., PMID:26942697
Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis., PMID:25746661
[Effects of uroacitides on the methylation of PTEN gene in myelodysplastic syndrome cells and its mechanism]., PMID:23906454
Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines., PMID:23397112
Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation., PMID:23179556
5-aza-2'-deoxycytidine leads to reduced embryo implantation and reduced expression of DNA methyltransferases and essential endometrial genes., PMID:23028963
Reduced susceptibility of DNA methyltransferase 1 hypomorphic (Dnmt1N/+) mice to hepatic steatosis upon feeding liquid alcohol diet., PMID:22905112
Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation., PMID:22563479
DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus., PMID:22236544
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma., PMID:21909138
A DNMT3B alternatively spliced exon and encoded peptide are novel biomarkers of human pluripotent stem cells., PMID:21698279
Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome., PMID:21559330
For research use only. Not for human or drug use.
