Catalog No.
YHJ72101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu145-Ala411
Predicted molecular weight
32.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UBB5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2, MBD2, DMTase, Demethylase
MBD2 promotes B cell differentiation and BCR signaling in systemic lupus erythematosus by regulating the LEF-1-PTEN-PI3K axis., PMID:40467564
Uncovering the Molecular Interactions Underlying MBD2 and MBD3 Phase Separation., PMID:40350613
Targeting redox-sensitive MBD2-NuRD condensate in cancer cells., PMID:40307576
Aged mice-derived bronchial epithelial cells regulate Th17 cell differentiation in asthma via the MBD2-sICOSL axis., PMID:40252480
Versatile functions of methyl-CpG-binding domain 2 (MBD2) in cellular characteristics and differentiation., PMID:40089655
MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2., PMID:40081619
The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma., PMID:39865866
Knockdown of Methylation-Related Gene MBD2 Blocks Cell Growth by Upregulating p21 Expression in Head and Neck Squamous Cell Carcinoma., PMID:39676597
MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5., PMID:39350229
Association between the copy number variations of Methyl-CpG binding domain family and schizophrenia., PMID:39127413
Exploring the Role of E6 and E7 Oncoproteins in Cervical Oncogenesis through MBD2/3-NuRD Complex Chromatin Remodeling., PMID:38790189
Arsenic disulfide promoted the demethylation of PTPL1 in diffuse large B cell lymphoma cells., PMID:38766487
Methyl CpG binding protein MBD2 has a regulatory role on the BRCA1 gene expression and its modulation by resveratrol in ER+, PR+ & triple-negative breast cancer cells., PMID:38711004
Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition., PMID:38556549
Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells., PMID:38201944
A paradigm for post-embryonic Oct4 re-expression: E7-induced hydroxymethylation regulates Oct4 expression in cervical cancer., PMID:38054553
Ascorbic Acid Induced the Improved Oxygen Vacancy Defects of Bi4O5Br2 and Its Application on Photoelectrochemical Detection of DNA Demethylase MBD2 with Improved Detection Sensitivity., PMID:38009777
C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies., PMID:37924864
BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells., PMID:37737560
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies., PMID:37669721
Methyl-CpG binding domain 2 (Mbd2) is an epigenetic regulator of autism-risk genes and cognition., PMID:37443311
MBD2a-NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression., PMID:37307480
Photoelectrochemical biosensor for DNA demethylase detection based on enzymatically induced double-stranded DNA digestion by endonuclease-exonuclease system and Bi4O5Br2-Au/CdS photoactive material., PMID:37245429
MBD2 facilitates tumor metastasis by mitigating DDB2 expression., PMID:37142578
The RCAN1.4 Metastasis Suppressor Is Hypermethylated at Intron 1 in Thyroid Cancer., PMID:37051697
miR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma., PMID:36961677
Methyl-cpg-binding Domain Protein 2 Silencing Inhibits Th17 Differentiation of CD4+T cells Induced by Ovalbumin., PMID:36932919
Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification., PMID:36864125
Methyl CpG binding domain protein 2 (MBD2) in inflammation., PMID:36728519
Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production., PMID:36090987
Copper binding leads to increased dynamics in the regulatory N-terminal domain of full-length human copper transporter ATP7B., PMID:36070320
Computational discovery of novel inhibitory candidates targeting versatile transcriptional repressor MBD2., PMID:36066769
Androgen Plays a Potential Novel Hormonal Therapeutic Role in Th17 Cells Predominant Neutrophilic Severe Asthma by Attenuating BECs Regulated Th17 Cells Differentiation via MBD2 Expression., PMID:36062195
MiR-6918-5p prevents renal tubular cell apoptosis by targeting MBD2 in ischemia/reperfusion-induced AKI., PMID:36057400
Density Control over MBD2 Receptor-Coated Surfaces Provides Superselective Binding of Hypermethylated DNA., PMID:36052432
Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3., PMID:36037972
Increased Methyl-CpG-Binding Domain Protein 2 Promotes Cigarette Smoke-Induced Pulmonary Hypertension., PMID:35785161
Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2., PMID:35734966
Identification of Chemical Probes Targeting MBD2., PMID:35649238
Methyl-CpG binding proteins (MBD) family evolution and conservation in plants., PMID:35278634
SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples., PMID:35272673
The study of expression levels of DNA methylation regulators in patients affected with congenital heart defects (CHDs)., PMID:35191222
Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma., PMID:35158098
Role of Sex Hormones at Different Physiobiological Conditions and Therapeutic Potential in MBD2 Mediated Severe Asthma., PMID:35096261
Loss of MBD2 ameliorates LPS-induced alveolar epithelial cell apoptosis and ALI in mice via modulating intracellular zinc homeostasis., PMID:35061304
circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis., PMID:35051313
Direct visualization by FRET-FLIM of a putative mechanosome complex involving Src, Pyk2 and MBD2 in living MLO-Y4 cells., PMID:34941939
Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP., PMID:34617573
MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis., PMID:34420035
GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex., PMID:33997955
For research use only. Not for human or drug use.
