Catalog No.
YHJ67401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu258
Predicted molecular weight
30.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NSE2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CIS-1, CIS, SOCS, Cytokine-inducible SH2-containing protein, CISH, Protein G18, Suppressor of cytokine signaling, G18
Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial., PMID:40315882
Exposure to an environmentally relevant concentration of chlorpyrifos induces transcriptional changes and neurotoxicity in Poecilia gillii without clear behavioral effects., PMID:39978101
A Phenotypically Distinct Human Th2 Cell Subpopulation Is Associated With Development of Allergic Disorders in Infancy., PMID:39899007
Sorting Out the SOCS Genes and Their Role in Macrophage Activation., PMID:39866122
Diagnosis of hydatidiform moles using p57 immunohistochemistry and chromogenic insitu hybridization: A retrospective study., PMID:39618719
Delayed Diagnosis of Inborn Errors of Immunity Due to CISH Gene Mutation Presenting As Recurrent Tuberculosis., PMID:39493080
Analysis of Cytokine-Inducible SH2-Containing Protein (CISH) in the Study of Immunosenescence., PMID:39348059
Canonical and Non-Canonical Functions of Erythropoietin and Its Receptor in Mature Nucleated Erythrocytes of Western Clawed Frog, Xenopus tropicalis., PMID:39093279
Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease., PMID:38127913
Cish knockout mice exhibit similar outcomes to malaria infection despite altered hematopoietic responses., PMID:38029163
ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4., PMID:37964351
Role of Cytokine-Inducible SH2 Domain-Containing (CISH) Protein in the Regulation of Erythropoiesis., PMID:37892192
The Role of Cytokine-Inducible SH2 Domain-Containing Protein (CISH) in the Regulation of Basal and Cytokine-Mediated Myelopoiesis., PMID:37628937
CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma., PMID:37563692
Therapeutic potential of icariin in rats with letrozole and high-fat diet-induced polycystic ovary syndrome., PMID:37269973
Erratum to: Intestinal Epithelial Cell-specific Deletion of Cytokine-inducible SH2-containing Protein Alleviates Experimental Colitis in Ageing Mice., PMID:37207690
CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging., PMID:37118554
Intestinal Epithelial Cell-specific Deletion of Cytokine-inducible SH2-containing Protein Alleviates Experimental Colitis in Ageing Mice., PMID:36881790
Expression of CISH, an Inhibitor of NK Cell Function, Increases in Association with Ovarian Cancer Development and Progression., PMID:36830840
Disruption of CISH promotes the antitumor activity of human T cells and decreases PD-1 expression levels., PMID:36654786
CIS controls the functional polarization of GM-CSF-derived macrophages., PMID:36471114
Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood-Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis., PMID:36289622
Hepatic cytokine-inducible SH2-containing protein (CISH) regulates gluconeogenesis via cAMP-responsive element binding protein (CREB)., PMID:36083102
Concurrent transposon engineering and CRISPR/Cas9 genome editing of primary CLL-1 chimeric antigen receptor-natural killer cells., PMID:36050244
CIS and TGF-β regulatory pathways influence immunity to bacterial infection., PMID:35611558
Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity., PMID:35589278
Increased accuracy of genomic predictions for growth under chronic thermal stress in rainbow trout by prioritizing variants from GWAS using imputed sequence data., PMID:35505881
Cytokine-inducible SH2 domain containing protein contributes to regulation of adiposity, food intake, and glucose metabolism., PMID:35470501
AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production., PMID:35333296
A 12-bp indel in the 3'UTR of porcine CISH gene associated with Landrace piglet diarrhea score., PMID:35325756
Effect Mechanism of Electroacupuncture at ST36 on the Injured Extensor Digitorum Longus in the Jumping Rat Model Based on mRNA-Seq Analysis., PMID:34944666
SOCS proteins and their roles in the development of glioblastoma., PMID:34820004
Allulose Attenuated Age-Associated Sarcopenia via Regulating IGF-1 and Myostatin in Aged Mice., PMID:34710274
CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone., PMID:34290377
Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer., PMID:34072601
Identification of a MicroRNA-E3 Ubiquitin Ligase Regulatory Network for Hepatocyte Death in Alcohol-Associated Hepatitis., PMID:34027272
Hematopoietic stem cells retain functional potential and molecular identity in hibernation cultures., PMID:33961793
Cytokine inducible SH2-containing protein potentiate J subgroup avian leukosis virus replication and suppress antiviral responses in DF-1 chicken fibroblast cells., PMID:33636239
Integrative Analyses of mRNA Expression Profile Reveal SOCS2 and CISH Play Important Roles in GHR Mutation-Induced Excessive Abdominal Fat Deposition in the Sex-Linked Dwarf Chicken., PMID:33519913
Suppression of IL-17A-induced CCL20 production by cytokine inducible SH2-containing protein 1 in epidermal keratinocytes., PMID:33509657
JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy., PMID:33245005
Ikaros antagonizes DNA binding by STAT5 in pre-B cells., PMID:33180866
MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking., PMID:32961483
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells., PMID:32902645
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity., PMID:32531207
Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD)., PMID:32114520
NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS., PMID:32097462
NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS., PMID:32082327
Bromodomain and Extraterminal Inhibition by JQ1 Produces Divergent Transcriptional Regulation of Suppressors of Cytokine Signaling Genes in Adipocytes., PMID:31875887
Treg expression of CIS suppresses allergic airway inflammation through antagonizing an autonomous TH2 program., PMID:31780776
For research use only. Not for human or drug use.
