Catalog No.
YHJ64701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu170-Lys338
Predicted molecular weight
20.64 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NQC7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deubiquitinating enzyme CYLD, Ubiquitin-specific-processing protease CYLD, Ubiquitin carboxyl-terminal hydrolase CYLD, CYLD1, KIAA0849, Ubiquitin thioesterase CYLD, CYLD
Endoplasmic reticulum stress induces trophoblast pyroptosis via regulating CYLD during labor initiation., PMID:40418867
SPATA2/CYLD Pathway-Dependent Deubiquitylation of p53 Promotes Ferroptosis in Rat Heart After Ischaemia/Reperfusion Through Suppression of SLC7A11., PMID:40389334
Deubiquitinating enzymes at the crossroads of blood-brain barrier integrity and neurodegeneration: mechanistic insights, therapeutic targeting and future directions., PMID:40358463
CYLD-mutated anal squamous cell carcinoma: An uncommon entity associated with cylindroma-like morphology and adverse clinical features., PMID:40180056
CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury., PMID:40108019
Naringenin alleviates heat stress-induced liver injury in Ningdu yellow chickens by decreasing RIPK3 and PDC binding., PMID:40054672
Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control., PMID:39958342
Role of CYLD in brain physiology and pathology., PMID:39945824
Truncating CYLD Pathogenic Variants in CYLD Cutaneous Syndrome Distinctly Influence CYLD Proteostasis and NF-κB Signaling., PMID:39924051
Porcine epidemic diarrhea coronavirus infection activates caspase-8 to enhance innate immunity by blocking CYLD-mediated deubiquitination of RIG-I., PMID:39908775
Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1., PMID:39908772
Overexpression of miR-155 Modulates Interferon Response and Inhibits Viral Replication of IHNV and IPNV in EPC Cells., PMID:39902831
HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1., PMID:39780247
The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells., PMID:39739815
VPO1 Promotes Programmed Necrosis of Cardiomyocytes in Rats with Chronic Heart Failure by Upregulating CYLD., PMID:39735991
Exosomes secreted from M2-polarized macrophages inhibit osteoclast differentiation via CYLD., PMID:39671756
Ubiquitin-Proteasome System in Periodontitis: Mechanisms and Clinical Implications., PMID:39626954
TRIM47 drives gastric cancer cell proliferation and invasion by regulating CYLD protein stability., PMID:39516831
A mechanism for hypoxia-induced inflammatory cell death in cancer., PMID:39506105
Mettl1 knockdown alleviates cardiac I/R injury in mice by inactivating the Mettl1-CYLD-P53 positive feedback loop., PMID:39414959
Case report: Multiple facial trichoepitheliomas caused by p.Val835SerfsTer52 variant of CYLD gene., PMID:39403278
Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma., PMID:39392932
CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments., PMID:39373352
CYLD Alterations Are Associated With Metastasis and Poor Prognosis in Human Papilloma Virus-Positive Head and Neck Cancer., PMID:39347568
Constitutive expression of the deubiquitinating enzyme CYLD does not affect microglia phenotype or function in homeostasis and neuroinflammation., PMID:39302418
Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells., PMID:39259342
Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination., PMID:39158695
Identification of Genetic Variants in Progressive Supranuclear Palsy in Southeast Asia., PMID:39149795
CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosis., PMID:39122680
Cyld restrains the hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axis., PMID:39122678
Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer., PMID:39082359
Grading Challenges and Prognostic Insights in Chromophobe Renal Cell Carcinoma: A Retrospective Study of 72 Patients., PMID:38929613
A computational approach for structural and functional analyses of disease-associated mutations in the human CYLD gene., PMID:38907316
Genetic and clinical landscape of Chinese frontotemporal dementia: dominance of TBK1 and OPTN mutations., PMID:38872230
MALT1 substrate cleavage: what is it good for?, PMID:38863711
A20 promoted the phagocytosis of lymphoma cells by dendritic cells from activated B-cell-like non-Hodgkin lymphoma., PMID:38814241
Dectin-1/SYK Activation Induces Antimicrobial Peptide and Negative Regulator of NF-κB Signaling in Human Oral Epithelial Cells., PMID:38688646
Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development., PMID:38677721
The TRIF-RIPK1-Caspase-8 signalling in the regulation of TLR4-driven gene expression., PMID:38618995
Megalosplenia as an initial manifestation of multiple myeloma with a novel CYLD gene mutation: A case report and literature review., PMID:38579060
CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1., PMID:38561786
RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation., PMID:38514849
Comparison of mutation landscapes of pretreatment versus recurrent squamous cell carcinoma of the oral cavity: The possible mechanism of resistance to standard treatment., PMID:38477073
A novel splicing CYLD variant associated with trichoepithelioma papulosum multiplex demonstrating intrafamilial severity variability., PMID:38444102
Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report., PMID:38348622
TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression., PMID:38319288
CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma., PMID:38287022
The miR-19a/Cylindromatosis Axis Regulates Pituitary Adenoma Bone Invasion by Promoting Osteoclast Differentiation., PMID:38254792
CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression., PMID:38246916
Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF-κB pathway toward SARS-CoV-2., PMID:38213785
For research use only. Not for human or drug use.
