Catalog No.
YHJ64601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro327
Predicted molecular weight
39.12 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NQA5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ECaC1, Calcium transport protein 2, Epithelial calcium channel 1, TRPV5, Osm-9-like TRP channel 3, ECAC1, Transient receptor potential cation channel subfamily V member 5, OTRPC3, CaT2, ECaC, TrpV5
Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment., PMID:40310296
Unlocking the potential of Bavachin in vitamin D receptor cascade modulation for rheumatoid arthritis., PMID:40285969
Partial renal deletion of Klotho is not sufficient to impact renal electrolyte handling in distal convoluted tubule specific knock-out mice., PMID:40165603
A novel small molecule NJH-13 induces pyroptosis via the Ca2+ driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5., PMID:39832720
Yak milk inhibits osteoclast differentiation by suppressing TRPV5 expression., PMID:39824495
Advances in the Study for Modulators of Transient Receptor Potential Vanilloid (TRPV) Channel Family., PMID:39757673
Calmodulin regulates TRPV5 intracellular trafficking and plasma membrane abundance., PMID:39576090
Renal expression of calcium and phosphorus transporters: contrasting responses to dietary calcium and microbial phytase in broilers and growing pigs., PMID:39417344
Impact of Lactobacillus acidophilus and Its Combination with Isoflavone Products on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in a Post-Menopausal Osteoporotic Rat Model., PMID:39125403
A successful conclusion to the long search for TRPV5 pathogenic variants in monogenic hypercalciuria., PMID:38839989
The ion channel TRPV5 regulates B-cell signaling and activation., PMID:38694510
TRPV1 signaling of perirenal adipose tissue promotes DOCA-Salt-induced hypertension and kidney injury., PMID:38690943
Lactobacillus helveticus-Derived Whey-Calcium Chelate Promotes Calcium Absorption and Bone Health of Rats Fed a Low-Calcium Diet., PMID:38674818
Ghrelin enhances tubular magnesium absorption in the kidney., PMID:38638279
Inhibition of pannexin-1 does not restore electrolyte balance in precystic Pkd1 knockout mice., PMID:38561249
Decreased calcium permeability caused by biallelic TRPV5 mutation leads to autosomal recessive renal calcium-wasting hypercalciuria., PMID:38528055
Ruthenium red: Blocker or antagonist of TRPV channels?, PMID:38518427
Molecular details of ruthenium red pore block in TRPV channels., PMID:38225355
Structural mechanism of TRPV5 inhibition by econazole., PMID:38141613
Probing Conformational Transition of TRPV5 Induced by Mechanical Force Using Coarse-Grained Molecular Dynamics., PMID:37871325
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era., PMID:37871124
Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls., PMID:37823200
Structural basis of the activation of TRPV5 channels by long-chain acyl-Coenzyme-A., PMID:37735536
Yak milk promotes renal calcium reabsorption in mice with osteoporosis via the regulation of TRPV5., PMID:37641274
Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis., PMID:37198647
Prepubertal to adulthood exposure to low doses of glyphosate-based herbicide increases the expression of the Havcr1 (Kim1) biomarker and causes mild kidney alterations., PMID:37001608
A cooperative knock-on mechanism underpins Ca2+-selective cation permeation in TRPV channels., PMID:36943243
Intracellular Helix-Loop-Helix Domain Modulates Inactivation Kinetics of Mammalian TRPV5 and TRPV6 Channels., PMID:36901904
Influence of glycoprotein MUC1 on trafficking of the Ca2+-selective ion channels, TRPV5 and TRPV6, and on in vivo calcium homeostasis., PMID:36682497
Furosemide rescues hypercalciuria in familial hypomagnesaemia with hypercalciuria and nephrocalcinosis model., PMID:36606514
Functional basis for calmodulation of the TRPV5 calcium channel., PMID:36566502
Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients., PMID:36477942
Renal Mechanisms for Hypercalciuria Induced by Metabolic Acidosis., PMID:36450225
Dynamic evolution of transient receptor potential vanilloid (TRPV) ion channel family with numerous gene duplications and losses., PMID:36387917
Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca2+ uptake and susceptibility to epithelial barrier dysfunction., PMID:36162385
Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions., PMID:36088585
Molecular insights into the structural and dynamical changes of calcium channel TRPV6 induced by its interaction with phosphatidylinositol 4,5-bisphosphate., PMID:35950523
Ca2+ transport via TRPV6 is regulated by rapid internalization of the channel., PMID:35917684
Investigating the Effects of Diet-Induced Pre-Diabetes on the Functioning of Calcium-Regulating Organs in Male Sprague Dawley Rats: Effects on Selected Markers., PMID:35898447
What structures did, and did not, reveal about the function of the epithelial Ca2+ channels TRPV5 and TRPV6., PMID:35834842
Metabolic and Genetic Evaluation in Children with Nephrolithiasis., PMID:35819704
FAM111A is dispensable for electrolyte homeostasis in mice., PMID:35715480
Title: Jealous protons sour another happy marriage; the story of how TRPV5 and PI(4,5)P2 split up., PMID:35667882
Structural snapshots of the mechanism of TRPV2 channel activation by small-molecule agonists., PMID:35636151
Multi-Omics Analysis of the Prognosis and Biological Function for TRPV Channel Family in Clear Cell Renal Cell Carcinoma., PMID:35558077
Structural basis of TRPV5 regulation by physiological and pathophysiological modulators., PMID:35476976
Aerobic exercise combined with glucosamine hydrochloride capsules inhibited the apoptosis of chondrocytes in rabbit knee osteoarthritis by affecting TRPV5 expression., PMID:35427733
miR-103a-3p Silencing Ameliorates Calcium Oxalate Deposition in Rat Kidney by Activating the UMOD/TRPV5 Axis., PMID:35251369
Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes†., PMID:35191486
Calcium selective channel TRPV6: Structure, function, and implications in health and disease., PMID:35031425
For research use only. Not for human or drug use.
