Catalog No.
YHJ63501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly210-Glu424
Predicted molecular weight
27.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NPH5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RENOX, NOX4, Renal NAD(P)H-oxidase, NADPH oxidase 4, Kidney oxidase-1, Kidney superoxide-producing NADPH oxidase, KOX-1
Medin induces pro-inflammatory activation of human brain vascular smooth muscle cells., PMID:40501029
Morinda officinalis oligosaccharides attenuate mitochondria-associated ferroptosis via the NOX4/mitoGPX4 pathway in myocardial ischemia‒reperfusion injury., PMID:40491951
USP38 stabilizes NOX4 and activates CaMKII to enhance ventricular arrhythmias susceptibility in CKD mice., PMID:40482978
Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway., PMID:40478189
Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway., PMID:40469629
Role of TGFβ-activated cancer-associated fibroblasts in the resistance to checkpoint blockade immunotherapy., PMID:40469190
Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes., PMID:40457435
NOX4 as an emerging prognostic and immunological biomarker across pan-cancer analyses., PMID:40442199
Unleashing the cardioprotective potential of berberine against doxorubicin cardiotoxicity: Innovative exploitation of the peculiar antipyroptotic/antioxidant/anti-inflammatory capacity via modulation of inflammasome/caspase-1/interleukin pathway in rats., PMID:40440959
Human Neural Progenitor Cell-Derived Exosomes Deliver miR- 100 - 5p Targeting NOX4 mRNA to Alleviate Oxidative Stress in Acute Ischemia Injury., PMID:40402409
The role of aldosterone on the endothelial dysfunction induced by female hormone deficiency., PMID:40379081
Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the activation of ATM/p53 in the neonatal mouse brain via JNK/p38 MAPK-mediated oxidative DNA damage., PMID:40378436
Cordycepin ameliorates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells through Smad7-dependent manner., PMID:40373638
Verbascoside as a potential SGLT2 inhibitor in diabetic nephropathy: Targeting AMPK activation to suppress NOX4/NF-κB signaling and attenuate inflammation and fibrosis., PMID:40373594
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4., PMID:40370565
Magnolia kobus DC. Alleviates adenine-induced chronic kidney disease by regulating ferroptosis in C57BL/6 mice., PMID:40365315
Diagnostic and Prognostic Potential of SH3YL1 and NOX4 in Muscle-Invasive Bladder Cancer., PMID:40362200
Green tea enriched with catechins prevents particulate matter2.5 exposure-induced cardiovascular cytotoxicity via regulation of ferroptosis in BALB/c mice., PMID:40351732
MicroRNA-9-5p Alleviates Oxidative Stress, Inflammation, and Apoptosis in Cerebral Ischemia-reperfusion Injury by Targeting NOX4 In vitro., PMID:40337970
Hypoxia and Hypoxia-Reoxygenation Potentiate Helicobacter pylori Infection and Gastric Epithelial Cell Proliferation., PMID:40325849
Protective effects and mechanisms of cynaroside on renal fibrosis in mice with unilateral ureteral obstruction., PMID:40322965
NOX4-driven mitochondrial oxidative stress in aging promotes myocardial remodeling and increases susceptibility to ventricular tachyarrhythmia., PMID:40320218
Fibroblast growth factor 18 attenuates renal fibrosis via AMPK/NOX4 pathway in mice., PMID:40311293
Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide., PMID:40305274
[Hypertension exacerbates postoperative learning and memory impairment in rats possibly due to UCP2 downregulation-mediated mitochondrial dysfunction]., PMID:40294922
P2X7 Receptor Facilitates Cardiomyocyte Autophagy After Myocardial Infarction via Nox4/PERK/ATF4 Signaling Pathway., PMID:40289672
MiR-367-3p Alleviates Oxidative Stress Injury in the Ischemia/Reperfusion Injury Cell Model by Targeting Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4-mediated Keap1/Nrf2/ARE Pathway., PMID:40289338
NFAT2 promotes sorafenib resistance in hepatocellular carcinoma cells by modulating calcium ion signalling., PMID:40288600
Xiasangju alleviates hepatic insulin resistance in db/db mice via AMPK pathway: Mechanisms and active components study., PMID:40286785
BRD4 Mediates Cadmium-Induced Oxidative Stress and Kidney Injury in Mice via Disruption of Redox Homeostasis., PMID:40278574
Probiotics promote cellular wound healing responses by modulating the PI3K and TGF-β/Smad signaling pathways., PMID:40269904
Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation., PMID:40269356
A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis., PMID:40243497
Add-On Dextromethorphan Improves the Effects of Pirfenidone in Bleomycin-Treated Mice and Patients With Pulmonary Fibrosis., PMID:40223283
Characterising the role of placental angiotensin-converting enzyme 2 (ACE2) during the onset of oxidative insult by hypoxia/reoxygenation: Implications for fetal growth restriction., PMID:40222298
Myeloid SHP2 attenuates myocardial ischemia‑reperfusion injury via regulation of BRD4/SYK/STING/NOX4/NLRP3 signaling., PMID:40211713
TNF-α/TLR4/IL-6/NF-κB Signaling Pathway and ROS/NOX4/p38/MDA Signaling Pathway Cross-Talk Involved in the Development of Vertebral Artery Stenosis/Occlusion in Elderly Patients., PMID:40207822
Astragalus mongholicus bunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling., PMID:40206091
Increased neprilysin expression is linked to atrial fibrotic remodeling in cardiovascular surgery patients., PMID:40201407
Effect of quercetin on inhibiting gefitinib‑activated non‑small cell lung cancer‑induced cell pyroptosis in cardiomyocytes via modulating mitochondrial autophagy mediated by the SHP2/ROS/AMPK/XBP‑1/DJ‑1 signaling pathway., PMID:40183386
Therapeutic S100A8/A9 inhibition reduces NADPH oxidase expression, reactive oxygen species production and NLRP3 inflammasome priming in the ischemic myocardium., PMID:40180274
Allopurinol attenuates development of Porphyromonas gingivalis LPS-induced cardiomyopathy in mice., PMID:40179080
Polyphyllin VII Enhances the Antitumor Activity of Cisplatin in Non-Small Cell Lung Cancer Cells by Inducing Ferroptosis and Enhancing Apoptosis., PMID:40165507
Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H2O2 and is protective against high-fat diet-induced dysfunction., PMID:40127093
Saponins from Astragalus membranaceus (Fisch.) Bge Alleviated Neuronal Ferroptosis in Alzheimer's Disease by Regulating the NOX4/Nrf2 Signaling Pathway., PMID:40119801
Vaccarin alleviates renal ischemia-reperfusion injury by inhibiting inflammation and ferroptosis., PMID:40112596
SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis., PMID:40098010
p-Coumaric acid alleviates neuronal damage in ischemic stroke mice by promoting BACH1 nuclear export and degradation., PMID:40087473
Remote Ischemic Preconditioning Attenuates Mitochondrial Dysfunction and Ferroptosis of Tubular Epithelial Cells by Inhibiting NOX4-ROS Signaling in Acute Kidney Injury., PMID:40083709
Cardiac ischaemia/reperfusion in pigs and mice increases cardiomyocyte Krüppel-like factor 5 that aggravates tissue injury and remodelling., PMID:40079359
For research use only. Not for human or drug use.
