Catalog No.
YHJ59101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu349-His592
Predicted molecular weight
53.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HB63
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Beta-netrin, Hepar-derived netrin-like protein, Netrin-4, NTN4
Rare Variant Association Analysis Uncovers Involvement of VNN2 in Stroke Outcome., PMID:40495801
Netrin 4 is a novel cytokine associated with oxidative stress and insulin resistance in obese individuals., PMID:40204125
Association Between Synovial NTN4 Expression and Pain Scores, and Its Effects on Fibroblasts and Sensory Neurons in End-Stage Knee Osteoarthritis., PMID:40136644
Protective Effect of Semaglutide on Obesity-Induced Renal Disease and Obesity-Induced Kidney Renal Clear Cell Carcinoma., PMID:40124099
Elevated Netrin-4 Expression and Its Action in Infrapatellar Fat Pad., PMID:39518922
Netrin‑4 promotes VE‑cadherin expression in endothelial cells through the NF‑κB signaling pathway., PMID:39071904
IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin-4 in an m6A-dependent manner., PMID:38780170
CD204-positive M2-like tumor-associated macrophages increase migration of gastric cancer cells by upregulating miR-210 to reduce NTN4 expression., PMID:38175202
EXOSC5 maintains cancer stem cell activity in endometrial cancer by regulating the NTN4/integrin β1 signalling axis., PMID:38164180
Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma., PMID:38156865
RNA‑binding protein quaking 5 inhibits the progression of non‑small cell lung cancer by upregulating netrin‑4 expression., PMID:37800632
Associations among the genome, rumen metabolome, ruminal bacteria, and milk production in early-lactation Holsteins., PMID:36894426
gga-miR-20b-5p inhibits infectious bursal disease virus replication via targeting Netrin 4., PMID:36796296
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney., PMID:36266461
NTN4 as a prognostic marker and a hallmark for immune infiltration in breast cancer., PMID:35732855
The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression., PMID:35687692
The Interaction of NTN4 and miR-17-92 Polymorphisms on Breast Cancer Susceptibility in a Chinese Population., PMID:35232666
RNA-seq Analysis Reveals Potential Molecular Mechanisms of ZNF580/ZFP580 Promoting Neuronal Survival and Inhibiting Apoptosis after Hypoxic-ischemic Brain damage., PMID:34929337
C/D box snoRNA SNORD113-6/AF357425 plays a dual role in integrin signalling and arterial fibroblast function via pre-mRNA processing and 2'O-ribose methylation., PMID:34673944
Anti-Inflammatory Role of Netrin-4 in Diabetic Retinopathy., PMID:33923095
Are serum Netrin-4 levels predictive of preeclampsia?, PMID:33447992
Soft hydrogel promotes dorsal root ganglion by upregulating gene expression of Ntn4 and Unc5B., PMID:33338883
eQTL Colocalization Analyses Identify NTN4 as a Candidate Breast Cancer Risk Gene., PMID:32871102
miR-17-5p promotes migration and invasion in breast cancer cells by repressing netrin 4., PMID:31933983
Ischemia-induced Netrin-4 promotes neovascularization through endothelial progenitor cell activation via Unc-5 Netrin receptor B., PMID:31914695
Transcriptomic and Proteomic Analyses Reveal the Potential Mode of Action of Chondrocyte Sheets in Hyaline Cartilage Regeneration., PMID:31878307
Enrichment of damaging missense variants in genes related with axonal guidance signalling in sporadic Meniere's disease., PMID:31494579
Lack of netrin-4 alters vascular remodeling in the retina., PMID:31451908
Monoclonal antibody AC10364 inhibits cell proliferation in 5-fluorouracil resistant hepatocellular carcinoma via apoptotic pathways., PMID:31303763
3'UTR variants of TNS3, PHLDB1, NTN4, and GNG2 genes are associated with IgA nephropathy risk in Chinese Han population., PMID:30928649
Genome-wide association meta-analysis of functional outcome after ischemic stroke., PMID:30796134
Notch1 activates angiogenic regulator Netrin4 in endothelial cells., PMID:30784178
Genome-Wide Association Analysis of Single-Breath DlCO., PMID:30694715
EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence., PMID:30514230
The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells., PMID:30160193
Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis., PMID:29720215
Hypoxia-Preconditioned Human Umbilical Vein Endothelial Cells Protect Against Neurovascular Damage After Hypoxic Ischemia in Neonatal Brain., PMID:29460267
Netrin-4 Promotes Differentiation and Migration of Osteoblasts., PMID:28882944
Netrin-4 Mediates Corneal Hemangiogenesis but Not Lymphangiogenesis in the Mouse-Model of Suture-Induced Neovascularization., PMID:28253401
The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration., PMID:28038459
Investigation of SNP rs2060546 Immediately Upstream to NTN4 in a Danish Gilles de la Tourette Syndrome Cohort., PMID:27920664
Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes., PMID:27901020
NTN4 is associated with breast cancer metastasis via regulation of EMT-related biomarkers., PMID:27840993
Identifying and targeting determinants of melanoma cellular invasion., PMID:27172792
Long noncoding RNA OR3A4 promotes metastasis and tumorigenicity in gastric cancer., PMID:26863570
Lack of netrin-4 modulates pathologic neovascularization in the eye., PMID:26732856
The Prediction of the Expected Current Selection Coefficient of Single Nucleotide Polymorphism Associated with Holstein Milk Yield, Fat and Protein Contents., PMID:26732326
Defects in neural guidepost structures and failure to remove leptomeningeal cells from the septal midline behind the interhemispheric fusion defects in Netrin1 deficient mice., PMID:26397040
Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data., PMID:26394601
Inhibition of human placental endothelial cell proliferation and angiogenesis by netrin-4., PMID:26390805
For research use only. Not for human or drug use.
