Catalog No.
YHJ57001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys1954-Ala2231
Predicted molecular weight
31.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H4A3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HSN2, Erythrocyte 65 kDa protein, Protein kinase lysine-deficient 1, KDP, p65, hWNK1, KIAA0344, Kinase deficient protein, Protein kinase with no lysine 1, Serine/threonine-protein kinase WNK1, PRKWNK1, WNK1
Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates., PMID:40493421
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity., PMID:40436823
WNK1 signalling regulates amino acid transport and mTORC1 activity to sustain acute myeloid leukaemia growth., PMID:40425534
LRRC8A in endothelial cells contributes to the aberrant blood-brain barrier integrity in ischaemic stroke., PMID:40096965
Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation., PMID:40060460
Comparative transcriptomic and hormone analyses reveal the molecular mechanisms regulating almond flowering stages., PMID:40007374
WNK1-dependent water influx is required for CD4+ T cell activation and T cell-dependent antibody responses., PMID:39984435
LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism., PMID:39975357
Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals., PMID:39859138
Osmotic stress influences microtubule drug response via WNK1 kinase signaling., PMID:39855050
ClC-5 knockout mitigates angiotensin II-induced hypertension and endothelial dysfunction., PMID:39740756
The evolving concepts of KS-WNK1 effect on NCC activity., PMID:39737691
A novel mutation in the WNK1/HSN2 gene causing hereditary sensory and autonomic neuropathy type 2 in Chinese patient., PMID:39710744
Familial Hyperkalemic Hypertension., PMID:39699086
Lnc_011797 promotes ferroptosis and aggravates white matter lesions., PMID:39688577
Bioinformatics analysis identifies WNK1 gene as a potential biomarker for cholangiocarcinoma diagnosis and immune infiltration., PMID:39674642
Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation., PMID:39627337
Bilobalide Activates Autophagy and Enhances the Efficacy of Bone Marrow Mesenchymal Stem Cells on Spinal Cord Injury Via Upregulating FMRP to Promote WNK1 mRNA Decay., PMID:39601946
Delayed vacuolation in mammalian cells caused by hypotonicity and ion loss., PMID:39592718
Water and chloride as allosteric inhibitors in WNK kinase osmosensing., PMID:39584807
Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms., PMID:39468717
Construction of a five-gene-based prognostic model for relapsed/refractory acute lymphoblastic leukemia., PMID:39453390
A Novel Pathogenic Mutation in WNK1 Gene Causing HSAN Type II in Three Siblings., PMID:39441469
The biology of water homeostasis., PMID:39435642
Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome., PMID:39389908
Phospholipase Cδ-4 (PLCδ4) Acts as a Nuclear Player to Influence Cyclin B Expression in the Embryonal Rhabdomyosarcoma Cell Lines RD and A204., PMID:39334946
CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1., PMID:39300342
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program., PMID:39298551
Prevalence of Hyperkalemia and Familial Hyperkalemic Hypertension in 5100 Patients Referred to a Tertiary Hypertension Unit., PMID:39229746
Chemokine-mediated F-actin dynamics, polarity, and migration in B lymphocytes depend on WNK1 signaling., PMID:39190707
SMURF1/2 are novel regulators of WNK1 stability., PMID:39131382
Chloride deregulation and GABA depolarization in MTOR-related malformations of cortical development., PMID:39106285
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure., PMID:39102426
Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia., PMID:39033662
The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation., PMID:38980795
L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift., PMID:38979610
Deletion of KS-WNK1 promotes NCC activation by increasing WNK1/4 abundance., PMID:38961847
Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis., PMID:38886655
WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma., PMID:38885324
Sex differences in dietary sodium evoked NCC regulation and blood pressure in male and female Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats., PMID:38813592
RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing., PMID:38809314
Phosphoproteomics reveals a novel mechanism underlying the proarrhythmic effects of nilotinib, vandetanib, and mobocertinib., PMID:38754619
Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma., PMID:38722741
Vascular smooth muscle-specific LRRC8A knockout ameliorates angiotensin II-induced cerebrovascular remodeling by inhibiting the WNK1/FOXO3a/MMP signaling pathway., PMID:38719954
Identification and In Vivo Validation of Unique Anti-Oncogenic Mechanisms Involving Protein Kinase Signaling and Autophagy Mediated by the Investigational Agent PV-10., PMID:38672602
Cullin-3 proteins be a novel biomarkers and therapeutic targets for hyperchloremia induced by oral poisoning., PMID:38615119
The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1., PMID:38599542
CYLD alleviates NLRP3 inflammasome-mediated pyroptosis in osteoporosis by deubiquitinating WNK1., PMID:38561786
Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis., PMID:38287200
Profiling Kinase Activities for Precision Oncology in Diffuse Gastric Cancer., PMID:38271566
For research use only. Not for human or drug use.
