Catalog No.
YHJ49001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala24-Cys366
Predicted molecular weight
40.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BQS7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HEPH, KIAA0698, Hephaestin
COMM domain containing 4 inhibits hephaestin and ferroportin to enhance neuronal ferroptosis by disturbing the Cu-Fe balance in amyotrophic lateral sclerosis., PMID:40389143
Functional Characterization of the Hephaestin Variant D568H Provides Novel Mechanistic Insights on Iron-Dependent Asbestos-Induced Carcinogenesis., PMID:40141249
Study on yolk iron transportation in chick embryo eggs based on transcriptomics., PMID:40073683
TCONS_00025035-miR-101-UROS is potentially involved in the regulation of heme synthesis pathway and influences mantle melanin deposition by targeting porphyrin in Manila clam (Ruditapes philippinarum)., PMID:39461636
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex., PMID:39152201
The Extract of Gloiopeltis tenax Enhances Myogenesis and Alleviates Dexamethasone-Induced Muscle Atrophy., PMID:38928510
STAG2 mutations regulate 3D genome organization, chromatin loops, and Polycomb signaling in glioblastoma multiforme., PMID:38705393
Preclinical Efficacy of Peripheral Nerve Regeneration by Schwann Cell-like Cells Differentiated from Human Tonsil-Derived Mesenchymal Stem Cells in C22 Mice., PMID:38137555
In vitro evaluation of the effect of yogurt acid whey fractions on iron bioavailability., PMID:37709016
Quercetin Inhibits Hephaestin Expression and Iron Transport in Intestinal Cells: Possible Role of PI3K Pathway., PMID:36904205
Effects of Sulla Flexuosa Hay as Alternative Feed Resource on Goat's Milk Production and Quality., PMID:36830499
Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients., PMID:36600108
Trio-based exome sequencing broaden the genetic spectrum in keratoconus., PMID:36502923
Transcriptomic analysis reveals the effects of maternal selenium deficiency on placental transport, hormone synthesis, and immune response in mice., PMID:36002020
Zinc induces hephaestin expression via a PI3K-CDX2 dependent mechanism to regulate iron transport in intestinal Caco-2 cells., PMID:35963044
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway., PMID:35658231
Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis., PMID:35271829
Minimal effect of conditional ferroportin KO in the neural retina implicates ferrous iron in retinal iron overload and degeneration., PMID:35202704
The biology of mammalian multi-copper ferroxidases., PMID:35167013
TMT Quantitative Proteomics Analysis Reveals the Effects of Transport Stress on Iron Metabolism in the Liver of Chicken., PMID:35011158
Effect of zinc depletion/repletion on intestinal iron absorption and iron status in rats., PMID:34118433
Effect of atrazine on accumulation of iron via the iron transport proteins in the midbrain of SD rats., PMID:34030342
Impact of maternal iron deficiency anaemia on the expression of the newly discovered multi-copper ferroxidase, Zyklopen, in term placentas., PMID:33938360
Iron Transporter Protein Expressions in Children with Celiac Disease., PMID:33673530
Cancer-associated fibroblast-derived exosomal microRNA-24-3p enhances colon cancer cell resistance to MTX by down-regulating CDX2/HEPH axis., PMID:33621425
Blood-brain barrier permeability towards small and large tracers in a mouse model of osmotic demyelination syndrome., PMID:33497716
Relationship between Down-Regulation of Copper-Related Genes and Decreased Ferroportin Protein Level in the Duodenum of Iron-Deficient Piglets., PMID:33396831
Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling., PMID:33264304
Transcriptome analysis of the hypothalamus and pituitary of turkey hens with low and high egg production., PMID:32957911
miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer., PMID:32534701
Distinct iron homeostasis in C57BL/6 and Balb/c mouse strains., PMID:32385968
Immunosuppressant-Induced Oxidative Stress and Iron: A Paradigm Shift from Systemic to Intrahepatic Abnormalities., PMID:32318243
Gestational diabetes mellitus affects placental iron homeostasis: Mechanism and clinical implications., PMID:32285992
A Connected Network of Interacting Proteins Is Involved in Human-Tau Toxicity in Drosophila., PMID:32116515
Characterization of the hypothalamo-pituitary-gonadal axis in low and high egg producing turkey hens., PMID:32029148
Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption., PMID:31973819
Active compounds of herbs ameliorate impaired cognition in APP/PS1 mouse model of Alzheimer's disease., PMID:31816602
Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains., PMID:31755170
Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens., PMID:31632293
Multi-copper ferroxidase deficiency leads to iron accumulation and oxidative damage in astrocytes and oligodendrocytes., PMID:31263155
Biallelic HEPHL1 variants impair ferroxidase activity and cause an abnormal hair phenotype., PMID:31125343
Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster., PMID:31085682
Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain., PMID:30799697
Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux., PMID:30647129
Adipose Tissue Expansion by Overfeeding Healthy Men Alters Iron Gene Expression., PMID:30260393
Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin., PMID:30182051
Deletion of hephaestin and ceruloplasmin induces a serious systemic iron deficiency and disrupts iron homeostasis., PMID:30060949
Organ‑specific expression of the divalent ion channel proteins NCKX3, TRPV2, CTR1, ATP7A, IREG1 and HEPH in various canine organs., PMID:29901089
Ceruloplasmin and hephaestin jointly protect the exocrine pancreas against oxidative damage by facilitating iron efflux., PMID:29883959
Validation of Osteogenic Properties of Cytochalasin D by High-Resolution RNA-Sequencing in Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissues., PMID:29882479
For research use only. Not for human or drug use.
