Catalog No.
YHJ45701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Trp145-Ala275
Predicted molecular weight
17.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99665
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-12R subunit beta-2, IL-12 receptor subunit beta-2, IL-12R-beta-2, Interleukin-12 receptor subunit beta-2, IL12RB2, IL-12RB2
NK Cells Modulate Dendritic Cell (DC) Signaling Pathways and DC Recruitment in Chlamydial Infection., PMID:40332391
Autoantigen and IL-2 activated CD4+CD25+T regulatory cells are induced to express CD8 and are autoantigen specific in inhibiting experimental autoimmune encephalomyelitis., PMID:40228404
Roles of the CDCA gene family in breast carcinoma., PMID:39814554
Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn's disease patients with a severe disease course., PMID:39586377
Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease., PMID:39462545
Gene expression changes in Brodmann's Area 46 differentiate epidermal growth factor and immune system interactions in schizophrenia and mood disorders., PMID:39242583
Structure and assembly of the human IL-12 signaling complex., PMID:39111304
Deciphering Molecular Mechanisms of Cutaneous Leishmaniasis, Pathogenesis and Drug Repurposing through Systems Biology., PMID:39036455
Chlamydia muridarum Associated Pulmonary and Urogenital Disease and Pathology in a Colony of Enzootically Infected Il12rb2 Deficient and Stat1 Knockout Mice., PMID:38561234
The IL-21/IL-21R signaling axis regulates CD4+ T-cell responsiveness to IL-12 to promote bacterial-induced colitis., PMID:38498592
Achyranthes bidentata polysaccharides improve cyclophosphamide-induced adverse reactions by regulating the balance of cytokines in helper T cells., PMID:38479672
Sulforaphane activates CD8+ T cells antitumor response through IL-12RB2/MMP3/FasL-induced MDSCs apoptosis'., PMID:38296593
C1QBP is a critical component in the immune response of large yellow croaker (Larimichthys crocea) against visceral white spot disease caused by Pseudomonas plecoglossicida., PMID:38218420
Immunomodulatory properties of bacteriophage derived dsRNA of different size and their use as anticancer vaccine adjuvants., PMID:38184395
Immune-related gene IL17RA as a diagnostic marker in osteoporosis., PMID:37600656
Seven Immune-Related Genes' Prognostic Value and Correlation with Treatment Outcome in Head and Neck Squamous Cell Carcinoma., PMID:39282247
Assessment of the Potential Role of Selected Single Nucleotide Polymorphisms (SNPs) of Genes Related to the Functioning of Regulatory T Cells in the Pathogenesis of Psoriasis., PMID:37047033
IFNγ-induction of TH1-like regulatory T cells controls antiviral responses., PMID:36928412
Integrated analysis of ATAC-seq and RNA-seq reveals the transcriptional regulation network in SLE., PMID:36738683
The Absence of IL-12Rβ2 Expression on Recipient Nonhematopoietic Cells Diminishes Acute Graft-versus-Host Disease in the Gastrointestinal Tract., PMID:36548465
Detailed phenotypic and functional characterization of CMV-associated adaptive NK cells in rhesus macaques., PMID:36518759
Role of Genetic Polymorphisms in IL12Rβ2 in Chronic Obstructive Pulmonary Disease., PMID:35923356
Interleukin-10 and its receptors at the maternal-conceptus interface: expression, regulation, and implication for T helper 2 cytokine predominance and maternal immune tolerance in the pig, a true epitheliochorial placentation species†., PMID:35348632
Immunopathogenesis of Behçet's disease and treatment modalities., PMID:35038644
Adaptive Immune Response Signaling Is Suppressed in Ly6Chigh Monocyte but Upregulated in Monocyte Subsets of ApoE-/- Mice - Functional Implication in Atherosclerosis., PMID:34987524
Blood transcriptome analysis revealed the immune changes and immunological adaptation of wildness training giant pandas., PMID:34985592
Comprehensive Analysis of CPA4 as a Poor Prognostic Biomarker Correlated with Immune Cells Infiltration in Bladder Cancer., PMID:34827136
Influence of Genetic Polymorphisms on Clinical Outcomes of Glatiramer Acetate in Multiple Sclerosis Patients., PMID:34683173
IL-12 regulates type 3 immunity through interfollicular keratinocytes in psoriasiform inflammation., PMID:34678045
CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients., PMID:34149710
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells., PMID:34050263
NanoString technology distinguishes anti-TIF-1γ+ from anti-Mi-2+ dermatomyositis patients., PMID:34043263
Interleukin-35 regulates peripheral T cell activity in patients with Kawasaki disease., PMID:33862556
Expressions of IL-12 and its receptors in patients with lumbar disc herniation and their relationship with clinical efficacy., PMID:33287915
A comprehensive overview on the genetics of Behçet's disease., PMID:33258398
A First Step for the Molecular Characterization of Neurological Involvement of Behçet Syndrome: an Italian Pivotal Study., PMID:33216288
Identification of prognostic genes in uveal melanoma microenvironment., PMID:33196683
Gene expression profile of normal breast tissue and body mass index., PMID:33185850
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis., PMID:33154757
Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction., PMID:32801995
Production of IL-17A at Innate Immune Phase Leads to Decreased Th1 Immune Response and Attenuated Host Defense against Infection with Cryptococcus deneoformans., PMID:32561568
Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors., PMID:32518162
Autocrine TGF-β1 Maintains the Stability of Foxp3+ Regulatory T Cells via IL-12Rβ2 Downregulation., PMID:32471185
Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival., PMID:32450888
Transcription factor p73 regulates Th1 differentiation., PMID:32193462
Alloactivation of Naïve CD4+CD8-CD25+T Regulatory Cells: Expression of CD8α Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction., PMID:31681288
DNA hypermethylation is associated with invasive phenotype of malignant melanoma., PMID:31602702
Gene expression profile of human T cells following a single stimulation of peripheral blood mononuclear cells with anti-CD3 antibodies., PMID:31324145
Characterization of two novel mutations in IL-12R signaling in MSMD patients., PMID:31158284
Transcriptome analysis of juvenile genetically improved farmed tilapia (Oreochromis niloticus) livers by dietary resveratrol supplementation., PMID:31028934
For research use only. Not for human or drug use.
