Catalog No.
YHJ45601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-His195
Predicted molecular weight
24.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99653
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium-binding protein CHP, Calcineurin B homologous protein 1, CHP, Calcium-binding protein p22, Calcineurin B-like protein, CHP1, EF-hand calcium-binding domain-containing protein p22
A novel golgi related genes based correlation prognostic index can better predict the prognosis of glioma and responses to immunotherapy., PMID:39976877
A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A., PMID:39900909
Repurposing of Empagliflozin as Cardioprotective Drug: An in-silico Approach., PMID:39686639
Revealing disease subtypes and heterogeneity in common variable immunodeficiency through transcriptomic analysis., PMID:39396099
Whole-Genome Resequencing Reveals Significant Genetic Differentiation Between Exserohilum turcicum Populations from Maize and Sorghum and Candidate Effector Genes Related to Host Specificity., PMID:39052468
Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis., PMID:38360885
Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy., PMID:38166692
Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study., PMID:37735703
Cytotoxicity of alkaline serine protease (ASPNJ) on Jurkat cells and its correlation with changes in the expression of membrane-associated proteins., PMID:37439684
Aerobic exercise training resets the human skeletal muscle methylome 10 years after breast cancer treatment and survival., PMID:36542473
Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks., PMID:35724821
Structural basis of autoinhibition of the human NHE3-CHP1 complex., PMID:35613257
Structure and mechanism of the human NHE1-CHP1 complex., PMID:34108458
Involvement of CHP2 in the Development of Non-Small Cell Lung Cancer and Patients' Poor Prognosis., PMID:33030853
Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings., PMID:32787936
Calcineurin homologous protein isoform 2 supports tumor survival via the sodium hydrogen exchanger isoform 1 in non-small cell lung cancer., PMID:32686600
Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates., PMID:32397415
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells., PMID:32053105
Azorhizobium caulinodans c-di-GMP phosphodiesterase Chp1 involved in motility, EPS production, and nodulation of the host plant., PMID:32002604
The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen., PMID:31917826
Calcium affects CHP1 and CHP2 conformation and their interaction with sodium/proton exchanger 1., PMID:31912575
Drosophila Morgana is an Hsp90-interacting protein with a direct role in microtubule polymerisation., PMID:31907206
The metal-binding properties of the long chaplin from Streptomyces mobaraensis: A bioinformatic and biochemical approach., PMID:31698184
PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice., PMID:31607845
Polyhexamethyleneguanidine Phosphate-Induced Cytotoxicity in Liver Cells Is Alleviated by Tauroursodeoxycholic Acid (TUDCA) via a Reduction in Endoplasmic Reticulum Stress., PMID:31484321
Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA., PMID:31255284
Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in Schizosaccharomyces pombe., PMID:31000521
Isolation and identification of iron-chelating peptides from casein hydrolysates., PMID:30993279
CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4., PMID:30846317
Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after Subarachnoid Hemorrhage both in vivo and in vitro via Promoting Neuronal Apoptosis., PMID:30838887
HSP90 and Its Novel Co-Chaperones, SGT1 and CHP-1, in Brain of Patients with Parkinson's Disease and Dementia with Lewy Bodies., PMID:30741686
Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription., PMID:30652128
CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a., PMID:29967111
CHP1 reduction ameliorates spinal muscular atrophy pathology by restoring calcineurin activity and endocytosis., PMID:29961886
Self-selection of plant bioactive compounds by sheep in response to challenge infection with Haemonchus contortus., PMID:29906471
Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function., PMID:29379881
Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi., PMID:29237752
Regulation of transcriptional silencing and chromodomain protein localization at centromeric heterochromatin by histone H3 tyrosine 41 phosphorylation in fission yeast., PMID:29136238
Transcriptional dysregulation of Interferome in experimental and human Multiple Sclerosis., PMID:28827704
Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines., PMID:28599655
Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB., PMID:28228545
Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells., PMID:27751915
Down-regulation of Na+/H+ exchanger 1 by Toll-like receptor stimulation in macrophages., PMID:27771174
The Chp1 chromodomain binds the H3K9me tail and the nucleosome core to assemble heterochromatin., PMID:27462451
Role of Inner Nuclear Membrane Protein Complex Lem2-Nur1 in Heterochromatic Gene Silencing., PMID:27451393
The canine prostate cancer cell line CHP-1 shows over-expression of the co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α., PMID:26762899
[Structure, Immunogenicity and Clinical Value of Chlamydiaphage Capsid Protein 3]., PMID:26524915
Sgf73, a subunit of SAGA complex, is required for the assembly of RITS complex in fission yeast., PMID:26443059
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity., PMID:26208319
The Na+/H+ Exchanger-3 (NHE3) Activity Requires Ezrin Binding to Phosphoinositide and Its Phosphorylation., PMID:26042733
For research use only. Not for human or drug use.
