Catalog No.
YHJ43301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro64-Lys331
Predicted molecular weight
32.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99435
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein kinase C-binding protein NELL2, NRP2, NELL2, Nel-related protein 2, NEL-like protein 2
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling., PMID:40210857
NELL2 suppresses epithelial-mesenchymal transition and induces ferroptosis via notch signaling pathway in HCC., PMID:40133552
Glu592 of the axon guidance receptor ROBO3 mediates a pH-dependent interaction with NELL2 ligand., PMID:39531524
CH25H Promotes Autophagy and Regulates the Malignant Progression of Laryngeal Squamous Cell Carcinoma Through the PI3K-AKT Pathway., PMID:39428922
Aquilaria crassna Extract Exerts Neuroprotective Effect against Benzo[a]pyrene-Induced Toxicity in Human SH-SY5Y Cells: An RNA-Seq-Based Transcriptome Analysis., PMID:39203863
Identifying plasma proteomic signatures from health to heart failure, across the ejection fraction spectrum., PMID:38937570
Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome., PMID:38600586
Busulfan administration replicated the characteristics of the epididymal initial segment observed in mice lacking testis-epididymis lumicrine signaling., PMID:38346723
Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract., PMID:38169386
Distinguishing Natural Infections of the Bovine Mammary Gland by Staphylococcus from Streptococcus spp. Using Quantitative Milk Proteomics., PMID:37889706
Adhesion G protein-coupled receptor G2 is dispensable for lumicrine signaling regulating epididymal initial segment differentiation and gene expression†., PMID:37531264
A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility., PMID:37095084
Integrated Proteotranscriptomics Reveals Differences in Molecular Immunity between Min and Large White Pig Breeds., PMID:36552219
NELL2 as a potential marker of outcome in the cerebrospinal fluid of patients with tuberculous meningitis: preliminary results from a single-center observational study., PMID:36494747
Positioning-dependent bidirectional NELL2 signaling in the brain., PMID:36329889
Gene Profiling of a 3D Psoriatic Skin Model Enriched in T Cells: Downregulation of PTPRM Promotes Keratinocyte Proliferation through Excessive ERK1/2 Signaling., PMID:36139479
The molecular mechanisms of mammalian sperm maturation regulated by NELL2-ROS1 lumicrine signaling., PMID:36071564
Transcriptional Regulatory Role of NELL2 in Preproenkephalin Gene Expression., PMID:35950455
Conformational Change of the Hairpin-like-structured Robo2 Ectodomain Allows NELL1/2 Binding., PMID:35940226
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes., PMID:35484513
Neural Epidermal Growth Factor-Like Like Protein 2 Is Expressed in Human Oligodendroglial Cell Types., PMID:35265611
Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells., PMID:34926447
A seven-gene prognostic model related to immune checkpoint PD-1 revealing overall survival in patients with lung adenocarcinoma., PMID:34517527
Identification of candidate genomic regions for chicken egg number traits based on genome-wide association study., PMID:34376144
Anoctamin 5 promotes osteosarcoma development by increasing degradation of Nel-like proteins 1 and 2., PMID:34238763
NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth., PMID:34233189
NELL2 modulates cell proliferation and apoptosis via ERK pathway in the development of benign prostatic hyperplasia., PMID:34195782
m6A demethylase FTO induces NELL2 expression by inhibiting E2F1 m6A modification leading to metastasis of non-small cell lung cancer., PMID:34169146
A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods., PMID:33903940
The tRNA-Derived Fragment-3017A Promotes Metastasis by Inhibiting NELL2 in Human Gastric Cancer., PMID:33665159
Neural EGFL like 2 expressed in myoepithelial cells and suppressed breast cancer cell migration., PMID:33657249
Dbx2 regulation in limbs suggests interTAD sharing of enhancers., PMID:33497014
NELL2 Function in Axon Development of Hippocampal Neurons., PMID:32597395
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility., PMID:32499443
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance., PMID:32198364
Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients., PMID:30786925
Nell2 regulates the contralateral-versus-ipsilateral visual projection as a domain-specific positional cue., PMID:30745429
Robo2 contains a cryptic binding site for neural EGFL-like (NELL) protein 1/2., PMID:30700556
In search of cerebrospinal fluid biomarkers of fatigue in multiple sclerosis: A proteomics study., PMID:29961995
Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma., PMID:29704232
Screening key genes for abdominal aortic aneurysm based on gene expression omnibus dataset., PMID:29439675
lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1., PMID:28429752
A Role of Central NELL2 in the Regulation of Feeding Behavior in Rats., PMID:28301916
Methyl-β-cyclodextrin treatment combined to incubation with interleukin-4 reproduces major features of atopic dermatitis in a 3D-culture model., PMID:27833999
Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma., PMID:27550150
Methyl-β-cyclodextrin concurs with interleukin (IL)-4, IL-13 and IL-25 to induce alterations reminiscent of atopic dermatitis in reconstructed human epidermis., PMID:27304612
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2., PMID:26586761
Dissection of Thrombospondin-4 Domains Involved in Intracellular Adaptive Endoplasmic Reticulum Stress-Responsive Signaling., PMID:26459760
Haploinsufficiency of ANO6, NELL2 and DBX2 in a boy with intellectual disability and growth delay., PMID:25846056
iTRAQ-based quantitative proteomic analysis of cerebrospinal fluid reveals NELL2 as a potential diagnostic biomarker of tuberculous meningitis., PMID:25760060
For research use only. Not for human or drug use.
