Catalog No.
YHJ41001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala31-Val317
Predicted molecular weight
33.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96NY8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LNIR, NECTIN4, PRR4, Poliovirus receptor-related protein 4, Nectin cell adhesion molecule 4, Ig superfamily receptor LNIR, Nectin-4, PVRL4
The antibody-drug conjugate sacituzumab govitecan (IMMU-132) represents a potential novel therapeutic strategy in cholangiocarcinoma., PMID:40509933
Mechanistic Insights into Anti-Nectin4-VcMMAE-Induced Ocular Toxicity: From Cellular Uptake Pathways to Molecular Modification., PMID:40507807
Enfortumab vedotin induced interstitial lung disease: A first case report with pathological evidence from transbronchial lung cryobiopsy., PMID:40496844
KS-NailMel-1: a novel cell line of nail apparatus melanoma., PMID:40437181
Antibody-drug conjugates as game changers in bladder cancer: current progress and future directions., PMID:40433388
Ecology and evolutionary trajectories of morbilliviruses in Neotropical bats., PMID:40425830
E-VIRTUE: a study of enfortumab vedotin with or without pembrolizumab in rare genitourinary tumors-design and rationale., PMID:40421891
Assessment of trophoblast cell-surface antigen 2 (TROP2) and nectin-4 expression in choriocarcinoma., PMID:40414312
Trop2, Nectin-4, and PD-L1 expression profiles in esophageal squamous cell carcinoma: Implications for combined immunotherapy and ADC targeted therapies., PMID:40403357
NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors., PMID:40392373
Research hotspots and frontier analysis of the novel immune checkpoint Nectin-4., PMID:40380880
ImmunoPET Imaging of Nectin4 Expression in Gastric and Bladder Cancer Using [64Cu]Cu-NOTA-Padcev., PMID:40338113
Biomarkers of response to antibody-drug conjugates (TROP2 and nectin-4) and the immune microenvironment (NKG7, PD-L1, and B7-H3) in penile squamous cell carcinoma., PMID:40327767
The Significance of Nectin Family Proteins in Various Cancerogenous Processes., PMID:40244005
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy., PMID:40215164
Nectin-4 expression patterns and therapeutics in oncology., PMID:40209851
Emerging Paradigms in Genitourinary Cancers: Integrating Molecular Imaging, Hypoxia-Inducible Factor-Targeted Therapies, and Antibody-Drug Conjugates in Renal Cell and Urothelial Carcinomas., PMID:40198857
Amino acid changes accumulated in the fusion protein allow neuropathogenic measles viruses to use a broad repertoire of host factors for cell fusion triggering., PMID:40192292
Potency-optimized CD28-activating bispecific antibody for the targeted treatment of Nectin-4 positive cancers., PMID:40187750
Enfortumab vedotin and pembrolizumab: redefining the standard of care for previously untreated advanced urothelial cancer., PMID:40129250
Theranostic implications of Nectin-4 oncoprotein in gynecologic cancers: A review., PMID:40101551
A novel and promising therapeutic approach for treating pancreatic cancer: Nectin‑4‑targeted antibody‑drug conjugates alone or combined with autophagy inhibitors., PMID:40017149
225Ac/89Zr-Labeled N4MU01 Radioimmunoconjugates as Theranostics Against Nectin-4-Positive Triple-Negative Breast Cancer., PMID:39978811
Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells., PMID:39969205
Pilot Study of Nectin-4-Targeted PET Imaging Agent 68Ga-FZ-NR-1 in Triple-Negative Breast Cancer from Bench to First-in-Human., PMID:39947908
Nectin-4: A promising prognostic marker and therapeutic target in cancer., PMID:39939077
Durable response to treatment of an atypical desmoplastic small round cell tumor with enfortumab-vedotin., PMID:39928161
Association of body mass index and tumor response in metastatic urothelial carcinoma treated with enfortumab vedotin: data from the ULTRA-Japan consortium., PMID:39890750
Tissue-Based Biomarkers Important for Prognostication and Management of Genitourinary Tumors, Including Surrogate Markers of Genomic Alterations., PMID:39890303
Antibody-drug conjugates in urothelial carcinoma: current status and future., PMID:39844537
The validation and clinical bioanalysis of the Bicycle® Toxin Conjugate zelenectide pevedotin in human plasma., PMID:39829185
Spatial distribution and subtype-specific expression patterns of Nectin-4 in muscle-invasive bladder cancer., PMID:39801278
Exploring novel therapeutic targets in small bowel adenocarcinoma: insights from claudin 18.2, nectin-4, and HER3 expression analysis., PMID:39754977
Nectin-4 Expression in Prostatic Adenocarcinoma: An Immunohistochemical Study., PMID:39748460
Structure, Attachment and Transmembrane Internalisation of Peste Des Petits Ruminants Virus., PMID:39739994
NECTIN-4-redirected T cell Antigen Coupler T cells bearing CD28 show superior antitumor responses against solid tumors., PMID:39735536
Oncolytic measles virus-induced cell killing in radio-resistant and drug-resistant nasopharyngeal carcinoma., PMID:39731493
Treatment-related skin reactions in enfortumab vedotin as a surrogate marker of survival and treatment response., PMID:39681749
Preclinical Evaluation of an Al18F-Radiolabeled Bicyclic Peptide Targeting Nectin-4., PMID:39651703
The measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread., PMID:39641619
Nectin-4 Positivity in Genitourinary Malignancies: A Systematic Review., PMID:39626158
Assessing the expression of Nectin-4 in solid tumors by immunohistochemistry - what do we know?, PMID:39582282
Targeted therapeutic strategies for Nectin-4 in breast cancer: Recent advances and future prospects., PMID:39577073
Phase 2 Trial of Enfortumab Vedotin in Patients With Previously Treated Locally Advanced or Metastatic Urothelial Carcinoma in China., PMID:39530574
Phase II Trial of Enfortumab Vedotin in Patients With Previously Treated Advanced Head and Neck Cancer., PMID:39481054
Antibody-drug conjugates as targeted therapy for treating gynecologic cancers: update 2025., PMID:39480912
ETx-22, a Novel Nectin-4-Directed Antibody-Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4-Expressing Tumors., PMID:39440991
Novel Radiopharmaceuticals and Future of Theranostics in Genitourinary Cancers., PMID:39428326
The genomic and transcriptomic landscape of metastastic urothelial cancer., PMID:39366934
A cutting-edge 68Ga-labeled bicyclic peptide PET molecular probe for noninvasive assessment of Nectin4 expression., PMID:39213795
For research use only. Not for human or drug use.
