Catalog No.
YHJ40101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser501-Gly720
Predicted molecular weight
27.90 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96JJ3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Engulfment and cell motility protein 2, ELMO2, hCed-12A, KIAA1834, Protein ced-12 homolog A, CED12A
ELMO2 is an essential regulator of carotid artery development., PMID:40456777
ELMO2-related intraosseous vascular malformation: new cases with novel pathogenic variants, clinical follow-up and therapeutic approaches., PMID:39627357
Genetic Variants in the TBC1D2B Gene Are Associated with Ramon Syndrome and Hereditary Gingival Fibromatosis., PMID:39201553
Autism Spectrum Disorder- and/or Intellectual Disability-Associated Semaphorin-5A Exploits the Mechanism by Which Dock5 Signalosome Molecules Control Cell Shape., PMID:38666924
ELMO2 biallelic pathogenic variants in a patient with gingival hypertrophy and cherubism phenotype: Case report and molecular review., PMID:38517102
Role of cytoskeleton-related proteins in the acrosome reaction of Eriocheir sinensis spermatozoa., PMID:36782118
Proteome-Wide Identification of RNA-Dependent Proteins in Lung Cancer Cells., PMID:36551595
Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration., PMID:36400788
LncRNA Gm16638-201 Inhibits the 14-3-3Ɛ Pathway in the Murine Prefrontal Cortex to Induce Depressive Behaviors., PMID:36328497
Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1 -/- , elmo2 -/- , and elmo3 -/- Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins., PMID:35874819
Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state., PMID:32651375
ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis., PMID:32292657
Identification of lncRNA-associated differential subnetworks in oesophageal squamous cell carcinoma by differential co-expression analysis., PMID:32164040
Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization., PMID:31575859
Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain., PMID:31521773
Clinical and Molecular Study of ELMO-2-Related Massive Intraosseous Vascular Malformations: Lessons Learned From 25 Years of Follow-up., PMID:30882408
Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds., PMID:30604775
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion., PMID:30367035
HGF-induced formation of the MET-AXL-ELMO2-DOCK180 complex promotes RAC1 activation, receptor clustering, and cancer cell migration and invasion., PMID:30108175
Polarized Dock Activity Drives Shh-Mediated Axon Guidance., PMID:30078728
DNA Methylation Levels of the ELMO Gene Promoter CpG Islands in Human Glioblastomas., PMID:29495584
Homozygous mutation in ELMO2 may cause Ramon syndrome., PMID:29095483
Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes., PMID:27627840
Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells., PMID:27539661
Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling., PMID:27476657
Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation., PMID:27226625
An ELMO2-RhoG-ILK network modulates microtubule dynamics., PMID:25995380
ClipR-59 interacts with Elmo2 and modulates myoblast fusion., PMID:25572395
An Elmo-Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion., PMID:25452388
Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion., PMID:25332238
Essential role of Elmo1 in Dock2-dependent lymphocyte migration., PMID:24821968
Type VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes., PMID:24357722
Rac GEF Dock4 interacts with cortactin to regulate dendritic spine formation., PMID:23536706
ELMO recruits actin cross-linking family 7 (ACF7) at the cell membrane for microtubule capture and stabilization of cellular protrusions., PMID:23184944
Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways., PMID:22568984
Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2., PMID:22160594
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism., PMID:20679435
Quantitative analysis of HGF and EGF-dependent phosphotyrosine signaling networks., PMID:20222723
Integrin-linked kinase interactions with ELMO2 modulate cell polarity., PMID:19439446
Yersinia enterocolitica differentially modulates RhoG activity in host cells., PMID:19208761
Dock4 regulates dendritic development in hippocampal neurons., PMID:18615735
Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1., PMID:18602983
Nrsf silencing induces molecular and subcellular changes linked to neuronal plasticity., PMID:17496800
ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs., PMID:17452337
Signal transduction induced by apoptotic cells inhibits HIV transcription in monocytes/macrophages., PMID:16885500
Differential distribution of ELMO1 and ELMO2 mRNAs in the developing mouse brain., PMID:16443196
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12., PMID:14645848
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo., PMID:12879077
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex., PMID:12134158
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration., PMID:11595183
For research use only. Not for human or drug use.
