Catalog No.
YHJ39401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys271
Predicted molecular weight
33.59 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96FW1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OTU1, hOTU1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Deubiquitinating enzyme OTUB1, Otubain-1, OTUB1, Ubiquitin-specific-processing protease OTUB1, Ubiquitin thioesterase OTUB1, OTB1
The SOX18-OTUB1-YAP1 axis: a new endometriosis target., PMID:40500704
Mechanism of Curcumol Targeting the OTUB1/TGFBI Ubiquitination Pathway in the Inhibition of Angiogenesis in Colon Cancer., PMID:40430059
Ephedrine Attenuates LPS-Induced Acute Lung Injury in Mice by Inhibiting OTUB1 and Promoting K48 Ubiquitination of HIF1α., PMID:40387552
Targeting MYOF suppresses pancreatic ductal adenocarcinoma progression by inhibiting ILF3-LCN2 signaling through disrupting OTUB1-mediated deubiquitination of ILF3., PMID:40381229
SENP2-mediated deSUMOylation of NCOA4 protects against ferritinophagy-dependent ferroptosis in myocardial ischemia-reperfusion injury., PMID:40366738
Aldose reductase -mediated HUR ubiquitination enhances exosome release and hepatic fibrosis via ROS/PI3K/AKT pathway., PMID:40334999
OTUB1 enhances fatty acid oxidation in APAP-induced liver injury by mediating ACSL5 deubiquitination., PMID:40280245
Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis., PMID:40279639
Harnessing the Deubiquitinase USP1 for Targeted Protein Stabilization., PMID:40252079
FTO-mediated m6A Demethylation of OTUB1 stabilizes SLC7A11 to alleviate Ferroptosis in cerebral ischemia/reperfusion injury., PMID:40233842
Programmable protein stabilization with language model-derived peptide guides., PMID:40229275
USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment., PMID:40214647
CircSCD1 inhibits ferroptosis in breast Cancer through stabilizing SCD1 protein via deubiquitinase OTUB1., PMID:40210941
Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis., PMID:40169782
PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome., PMID:40158855
OTUB1 facilitates lipid accumulation in oxLDL-induced THP-1 macrophages by stabilizing scavenger receptor-A., PMID:40114404
OTUB1 promotes glioma progression by stabilizing TRAF4., PMID:40090557
OTUB1 promotes the progression of acute myeloid leukemia by regulating glycolysis via deubiquitinating c-Myc., PMID:40081551
Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation., PMID:39864589
OTUB1 mediates PARP1 deubiquitination to alleviate NAFLD by regulating HMGB1., PMID:39814124
Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway., PMID:39785769
VCP regulates early tau seed amplification via specific cofactors., PMID:39773263
PEX1G843D remains functional in peroxisome biogenesis but is rapidly degraded by the proteasome., PMID:39713301
Targeting and degradation of OTUB1 by Erianin for antimetastasis in esophageal squamous cell carcinoma., PMID:39566402
Tear fluid reflects the altered protein expressions of Alzheimer's disease patients in proteins involved in protein repair and clearance system or the regulation of cytoskeleton., PMID:39558606
Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation., PMID:39341821
CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2., PMID:39333496
Exploring the oncogenic potential of Aiolos in lung cancer through OTUB1-mediated ubiquitination., PMID:39315162
The deubiquitinase OTUB1 inhibits gluconeogenesis by stabilizing YWHAB., PMID:39270917
PILRB potentiates the PI3K/AKT signaling pathway and reprograms cholesterol metabolism to drive gastric tumorigenesis and metastasis., PMID:39227585
Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program., PMID:39217550
Research progress of the Otubains subfamily in hepatocellular carcinoma., PMID:39208669
Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer., PMID:39198663
The First-In-Class Deubiquitinase-Targeting Chimera Stabilizes and Activates cGAS., PMID:39150898
Vibrio splendidus infection promotes circRNA-FGL1-regulated coelomocyte apoptosis via competitive binding to Myc with the deubiquitinase OTUB1 in Apostichopus japonicus., PMID:39146353
Target deubiquitinase OTUB1 as a therapeatic strategy for BLCA via β-catenin/necroptosis signal pathway., PMID:39113709
Programmable Protein Stabilization with Language Model-Derived Peptide Guides., PMID:39108486
OTUB1 regulates ferroptosis to inhibit myoblast differentiation into myotubes by deubiquitinating P62., PMID:38977909
FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion., PMID:38977311
Overexpression of USP8 inhibits inflammation and ferroptosis in chronic obstructive pulmonary disease by regulating the OTUB1/SLC7A11 signaling pathway., PMID:38970266
TCF12 induces ferroptosis by suppressing OTUB1-mediated SLC7A11 deubiquitination to promote cisplatin sensitivity in oral squamous cell carcinoma., PMID:38946134
Evolutionarily conserved Otub1 suppresses antiviral immune response by promoting Irf3 proteasomal degradation in miiuy croaker, Miichthys miiuy., PMID:38914152
Grouper OTUB1 and OTUB2 promote red-spotted grouper nervous necrosis virus (RGNNV) replication by inhibiting the host innate immune response., PMID:38909637
VCP regulates early tau seed amplification via specific cofactors., PMID:38826306
Bacterial ubiquitin ligases hijack the host deubiquitinase OTUB1 to inhibit MTORC1 signaling and promote autophagy., PMID:38818749
OTUB1 contributes to the stability and function of Influenza A virus NS2., PMID:38814988
Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability., PMID:38664499
Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation., PMID:38663827
OTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death., PMID:38653740
Selective Hypoxia-Sensitive Oxomer Formation by FIH Prevents Binding of the NF-κB Inhibitor IκBβ to NF-κB Subunits., PMID:38644795
For research use only. Not for human or drug use.
