Catalog No.
YHJ39201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser43-Ala314
Predicted molecular weight
33.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96FI4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endonuclease 8-like 1, DNA glycosylase/AP lyase Neil1, Endonuclease VIII-like 1, Nei-like protein 1, DNA-(apurinic or apyrimidinic site) lyase Neil1, Nei homolog 1, NEIL1, FPG1, NEH1
Development and characterization of a novel NEIL1 nanobody., PMID:40440929
Aflatoxin B1-Induced Hepatic Mutagenesis in Mice Expressing Gene-Edited Neil1., PMID:40342069
DNA repair and disease: insights from the human DNA glycosylase NEIL family., PMID:40033009
Role of NEIL1 in genome maintenance., PMID:40010204
METTL14-mediated depression of NEIL1 aggravates oxidative damage and mitochondrial dysfunction of lens epithelial cells through regulating KEAP1/NRF2 pathways., PMID:39855533
NEIL1: The second DNA glycosylase involved in action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine., PMID:39848343
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model., PMID:39786590
The Distinct Roles of NEIL1 and XPA in Limiting Aflatoxin B1-Induced Mutagenesis in Mice., PMID:39387543
Artificial targeting of the NEIL1 DNA glycosylase to the mitochondria., PMID:39324705
E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model., PMID:39253444
Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis., PMID:39199284
Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis., PMID:39164210
Molecular basis and functional consequences of the interaction between the base excision repair DNA glycosylase NEIL1 and RPA., PMID:39025455
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations., PMID:38795603
DNA Repair Genetics and the Risk of Radiation Pneumonitis in Patients With Lung Cancer: A Systematic Review and Meta-analysis., PMID:38653664
Neil 1 deficiency facilitates chemoresistance through upregulation of RAD18 expression in ovarian cancer stem cells., PMID:38636303
Cognitive Function Is Associated with the Genetically Determined Efficiency of DNA Repair Mechanisms., PMID:38397143
Enhanced glutathione levels confer resistance to apoptotic and ferroptotic programmed cell death in NEIL DNA glycosylase deficient HAP1 cells., PMID:38301978
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1., PMID:38175757
Structural basis of nuclear transport for NEIL DNA glycosylases mediated by importin-alpha., PMID:38065227
Using Affinity Pulldown Assays to Study Protein-Protein Interactions of Human NEIL1 Glycosylase and the Checkpoint Protein RAD9-RAD1-HUS1 (9-1-1) Complex., PMID:37574484
Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations., PMID:37517321
Single-Nucleotide Polymorphisms in Base-Excision Repair-Related Genes Involved in the Risk of an Occurrence of Non-Alcoholic Fatty Liver Disease., PMID:37511066
Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine., PMID:37415806
Spontaneous allelic variant in deafness-blindness gene Ush1g resulting in an expanded phenotype., PMID:37328946
The Impact of Human DNA Glycosylases on the Activity of DNA Polymerase β toward Various Base Excision Repair Intermediates., PMID:37298543
DNA Repair Pathway in Ovarian Cancer Patients Treated with HIPEC., PMID:37240218
Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase., PMID:37014002
[DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells]., PMID:37000659
Endonuclease VIII-like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease., PMID:36840377
Autoantibody screening of plasma and peritoneal fluid of patients with endometriosis., PMID:36749097
The effects of altered DNA damage repair genes on mutational processes and immune cell infiltration in esophageal squamous cell carcinoma., PMID:36708047
PARP1 Gene Knockout Suppresses Expression of DNA Base Excision Repair Genes., PMID:36653586
WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis., PMID:36546838
Deregulated DNA damage response network in Behcet's disease., PMID:36400336
Bowhead NEIL1: molecular cloning, characterization, and enzymatic properties., PMID:36334646
Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases., PMID:36291061
TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability., PMID:36232914
NEIL3 promotes hepatoma epithelial-mesenchymal transition by activating the BRAF/MEK/ERK/TWIST signaling pathway., PMID:36181299
Analysis of Differences in DNA Damage and Repair Efficacy in Lymphocytes of Patients with Bipolar Disorder., PMID:36148566
Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast, India., PMID:36116241
Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A., PMID:35938152
NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific Recognition and Excision., PMID:35917336
Polymorphic variant Asp239Tyr of human DNA glycosylase NTHL1 is inactive for removal of a variety of oxidatively-induced DNA base lesions from genomic DNA., PMID:35870279
Sirt3 Regulates Response to Oxidative Stress by Interacting with BER Proteins in Colorectal Cancer., PMID:35440893
Structural and Evolutionary Adaptations of Nei-Like DNA Glycosylases Proteins Involved in Base Excision Repair of Oxidative DNA Damage in Vertebrates., PMID:35419164
p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain)., PMID:35190641
DNA-Protein Cross-Linking Sequencing for Genome-Wide Mapping of Thymidine Glycol., PMID:34978433
Conservation of A-to-I RNA editing in bowhead whale and pig., PMID:34882682
NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice., PMID:34857879
For research use only. Not for human or drug use.
