Catalog No.
YHJ38701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile194-Ser747
Predicted molecular weight
64.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96EB6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NAD-dependent protein deacylase sirtuin-1, hSIR2, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, 75SirT1, SIR2L1, Regulatory protein SIR2 homolog 1, SIRT1, hSIRT1
Alpha-asarone relieves nasal inflammation, epithelial barrier damage, and mitochondrial damage in allergic rhinitis by inhibiting mitochondrial ROS via the SIRT1/PGC-1α pathway., PMID:40514518
Reduced NF-κB/NLRP3/IL-18 signaling increases the protective effect of L-glutamine against LPS-induced retinal inflammation in mice: Utilization of network pharmacology and experimental validation., PMID:40513937
SIRT1 Regulates Iron Metabolism to Attenuate β-Cell Dedifferentiation by Inhibiting FoxO1 Acetylation., PMID:40512369
Brief Weekly Magnetic Field Exposure Enhances Avian Oxidative Muscle Character During Embryonic Development., PMID:40508230
Niacin Modulates SIRT1-Driven Signaling to Counteract Radiation-Induced Neurocognitive and Behavioral Impairments., PMID:40508105
Endarachne binghamiae Ameliorates Hepatic Steatosis, Obesity, and Blood Glucose via Modulation of Metabolic Pathways and Oxidative Stress., PMID:40507912
Repetitive Compressive Loading Downregulates Mitochondria Function and Upregulates the Cartilage Matrix Degrading Enzyme MMP-13 Through the Coactivation of NAD-Dependent Sirtuin 1 and Runx2 in Osteoarthritic Chondrocytes., PMID:40507779
Behavior of Complement System Effectors in Chronic and Acute Coronary Artery Disease., PMID:40507709
Dissimilar Effects of Selenite and Selenium Nanoparticles on Skeletal Muscle Development Unrelated to GPx1 Activity During Adolescence in Rats., PMID:40507111
Hexaraphane Affects the Activation of Hepatic PPARα Signaling: Impact on Plasma Triglyceride Levels and Hepatic Senescence with Aging., PMID:40507037
CLASP1 regulates Dynein for PLK1-mediated spindle organization and cytokinesis in oocyte meiosis., PMID:40501366
Omaveloxolone, But Not Dimethyl Fumarate, Improves Cardiac Function in Friedreich's Ataxia Mice With Severe Cardiomyopathy., PMID:40501183
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence., PMID:40499740
Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling., PMID:40492109
FOXQ1 Suppressing Apoptosis in Colorectal Cancer Cells by P53 Deacetylation., PMID:40491105
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer's Disease., PMID:40490662
Involvement of IL-6/JAK/STAT3/SOCS3, SIRT1, and Cytoglobin Signaling in Diacerein Protective Effect against Intestinal Injury Induced by Methotrexate., PMID:40488252
Gut microbiota-derived trimethylamine-N-oxide inhibits SIRT1 to regulate SM22α-mediated smooth muscle cell inflammation and promote atherosclerosis progression., PMID:40486531
Impact of sirtuin‑1 expression on progression‑free survival in non‑endometrioid endometrial cancer: A retrospective cohort study., PMID:40486084
Exploring the Lipid-Reducing Potential of Elsholtzia bodinieri Vaniot Essential Oil: Implications for HepG2 Cells and the Caenorhabditis elegans Obesity Models., PMID:40484708
Umbelliferone attenuates diabetic sarcopenia by modulating mitochondrial quality and the ubiquitin-proteasome system., PMID:40483791
Unraveling novel mechanisms of ATP-Binding cassette (ABC) transporter in insulin Resistance-induced amyloidogenesis., PMID:40482009
Effect of adding fenofibrate versus curcumin to glimepiride in patients with type 2 diabetes: a randomized controlled trial., PMID:40481568
Resveratrol reduces the activation of NLRP3 inflammasomes in rheumatoid arthritis through SIRT1 and ITGB α5β1, especially in patients with high expression of ACPA., PMID:40480022
Ginsenoside Rg1 Downregulates miR-9-5p Expression to Modulate SIRT1-Mediated Mitochondrial Dysfunction and Ameliorate Alzheimer's Disease., PMID:40478516
Vanillin alleviates oxidative stress-mediated neuronal pyroptosis induced in rats by isoproterenol via SIRT1/NOX4/ROS/TXNIP/NLRP3 signaling pathway., PMID:40478189
Investigation of HO-1 Regulation of Liver Fibrosis Related to Nonalcoholic Fatty Liver Disease Through the SIRT1/TGF-ß/Smad3 Pathway., PMID:40474887
Plant essential oil supplementation promotes growth and attenuates LPS-induced acute liver injury through SIRT1/PGC-1α signaling pathway in nursery pigs., PMID:40468731
The lactylation-immune regulatory axis: a potential therapeutic target for migraine prevention and treatment., PMID:40468199
TBX21 knockdown attenuates neuroinflammation induced by intracerebral hemorrhage via the SIRT1-WDR5-H3K4me3 axis., PMID:40466814
Deletion of Mex3c gene leads to autistic-like behavior in mice by inhibiting AMPK signal pathway., PMID:40463420
Effects of kidney-tonifying Chinese herbs on thymus regen-eration after rapamycin-induced degeneration in mice., PMID:40461290
[Advances in pathogenesis of asthma airway remodeling and intervention mechanism of traditional Chinese medicine]., PMID:40461218
Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway., PMID:40458823
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function., PMID:40457356
Chrysin Mitigates Chromium-Induced Nephrotoxicity Via Modulation of AMPK/SIRT1/NF-κB/p53 Signaling Cascade and PGC-1α Signaling., PMID:40457156
Ginsenoside Rg5 alleviates radiation-induced acute lung vascular endothelium injury by reducing mitochondrial apoptosis via Sirt1., PMID:40453348
Serum Levels of Nitric Oxide, SIRT1, MMP-9 and Telomerase in Children With Cognitive Disengagement Syndrome., PMID:40452502
Continuous exposure to low concentrations of antimony(III) induces inflammation, apoptosis, oxidative and endoplasmic reticulum stress in Caco-2 intestinal epithelial cells., PMID:40447031
Polysaccharide of Atractylodes macrocephala Koidz alleviated fructose-induced salt-sensitive hypertension and renal injury via suppressing SIRT1/Nlrp3/caspase-1 pathway in mice., PMID:40446979
Protective Effect of FABP5 Against 6-OHDA Induced Parkinson's Disease Via PPARγ/SIRT1/PGC-1α Signaling Pathway., PMID:40445460
Weissella confusa Attenuates Cognitive Deficits in Alzheimer's Disease by Reducing Oxidative Stress Via the SIRT1/PGC-1α Signaling Pathway., PMID:40445426
Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis., PMID:40442730
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway., PMID:40441663
Resveratrol attenuates prenatal X-ray-induced microcephaly and adult depression via SIRT1-mediated senescence suppression and TPH2/5-HT pathway restoration in mice., PMID:40440905
Marein from Coreopsis tinctoria Nutt. alleviates oxidative stress and lipid accumulation via SIRT1/Nrf2 signaling., PMID:40437103
Mito-TEMPO Mitigates Fibromyalgia Induced by Reserpine in Rats: Orchestration Between SIRT1, Mitochondrial Dynamics, Endoplasmic Reticulum and miRNA-320., PMID:40434586
FOXA2/miR-148a-3p/SMURF2 signaling feed-forward loop alleviates spinal cord ischemia-reperfusion injury-induced neuropathic pain by modulating microglia polarization in rats., PMID:40433390
Protective Effects of Panax notoginseng Saponins on Cerebral Ischemia/Reperfusion Injury: Insights Into SIRT1/NRF2/HO-1 Pathway Activation., PMID:40432445
Protective Effects of a Standardized Water Extract from the Stem of Ipomoea batatas L. Against High-Fat Diet-Induced Obesity., PMID:40431382
For research use only. Not for human or drug use.
