Catalog No.
YHJ38301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-His234
Predicted molecular weight
29.52 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96DC9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
OTUB2, Ubiquitin thioesterase OTUB2, Otubain-2, OTU domain-containing ubiquitin aldehyde-binding protein 2, C14orf137, Ubiquitin-specific-processing protease OTUB2, Deubiquitinating enzyme OTUB2, OTU2, OTB2
Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing., PMID:40476556
OTUB2 promotes proliferation and metastasis of triple-negative breast cancer by deubiquitinating TRAF6., PMID:40296903
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway., PMID:40253697
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke., PMID:40021931
Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2., PMID:39904430
OTUB2 contributes to vascular calcification in chronic kidney disease via the YAP-mediated transcription of PFKFB3., PMID:39776804
Genome-wide association studies of milk composition traits in indicine Badri cattle using ddRAD sequencing approach., PMID:39715884
Deubiquitination of RIPK2 by OTUB2 augments NOD2 signalling and protective effects in intestinal inflammation., PMID:39358938
OTU deubiquitinase, ubiquitin aldehyde binding 2 (OTUB2) modulates the stemness feature, chemoresistance, and epithelial-mesenchymal transition of colon cancer via regulating GINS complex subunit 1 (GINS1) expression., PMID:39210373
Research progress of the Otubains subfamily in hepatocellular carcinoma., PMID:39208669
The deubiquitinating enzymes-related signature predicts the prognosis and immunotherapy response in breast cancer., PMID:39115875
Grouper OTUB1 and OTUB2 promote red-spotted grouper nervous necrosis virus (RGNNV) replication by inhibiting the host innate immune response., PMID:38909637
circRNA6448-14/miR-455-3p/OTUB2 axis stimulates glycolysis and stemness of esophageal squamous cell carcinoma., PMID:38819228
Exploring the regulatory role of FBXL19-AS1 in triple-negative breast cancer through the miR-378a-3p/OTUB2 axis., PMID:38702967
OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition., PMID:38701117
Immunopeptidome mining reveals a novel ERS-induced target in T1D., PMID:38689020
Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2., PMID:38480480
The deubiquitinase OTUB2 promotes cervical cancer growth through stabilizing FOXM1., PMID:38322554
Pharmaceutical targeting of OTUB2 sensitizes tumors to cytotoxic T cells via degradation of PD-L1., PMID:38167274
Inhibition of OTUB2 suppresses colorectal cancer cell growth by regulating β-Catenin signaling., PMID:38058843
Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2., PMID:37642399
RBM15 m6 A modification-mediated OTUB2 upregulation promotes cervical cancer progression via the AKT/mTOR signaling., PMID:37334762
Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2., PMID:37169754
Deubiquitinase OTUB2 promotes intrahepatic cholangiocarcinoma progression by stabilizing the CTNNB1-ZEB1 axis., PMID:36858343
Overcoming AZD9291 Resistance and Metastasis of NSCLC via Ferroptosis and Multitarget Interference by Nanocatalytic Sensitizer Plus AHP-DRI-12., PMID:36420659
OTUB2 promotes the progression of endometrial cancer by regulating the PKM2-mediated PI3K/AKT signaling pathway., PMID:36316812
OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis., PMID:36288705
OTUB2 Regulates YAP1/TAZ to Promotes the Progression of Esophageal Squamous Cell Carcinoma., PMID:35850645
The Emerging Role of OTUB2 in Diseases: From Cell Signaling Pathway to Physiological Function., PMID:35309903
STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo., PMID:35298637
Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression., PMID:35024322
Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis., PMID:34671086
Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation., PMID:34465912
Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases., PMID:34071582
Two genes related to reproductive development in the juvenile prawn, Macrobrachium nipponense: Molecular characterization and transcriptional response to nanoplastic exposure., PMID:34015647
The functions and regulation of Otubains in protein homeostasis and diseases., PMID:33609777
WIDOCK: a reactive docking protocol for virtual screening of covalent inhibitors., PMID:33458809
Biallelic loss of OTUD7A causes severe muscular hypotonia, intellectual disability, and seizures., PMID:33381903
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer., PMID:32830515
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases., PMID:32265297
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-κB signaling., PMID:32003539
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening., PMID:31060360
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer., PMID:30662561
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ., PMID:30472188
Regulation of Gli2 stability by deubiquitinase OTUB2., PMID:30241937
Defective DNA repair increases susceptibility to senescence through extension of Chk1-mediated G2 checkpoint activation., PMID:27507734
The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages., PMID:25590432
Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice., PMID:24560272
Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets., PMID:23515685
Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis., PMID:20530642
For research use only. Not for human or drug use.
