Catalog No.
YHJ34001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro52-Ile426
Predicted molecular weight
43.39 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92859
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IGDCC2, NEO1, Neogenin, NGN, Immunoglobulin superfamily DCC subclass member 2
Causal roles of lipids and mediating proteins in diabetic retinopathy: insights from metabolomic and proteomic Mendelian randomization., PMID:40287778
Exploring the functional variations of key candidate genes affecting egg production by hypothalamic-pituitary-ovarian axis in chickens., PMID:40132314
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
(Apo)Lipoprotein Profiling with Multi-Omics Analysis Identified Medium-HDL-Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease., PMID:39985383
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis., PMID:39953266
Mapping the Cerebrospinal Fluid Proteome in Bipolar Disorder., PMID:39827936
Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings., PMID:39588913
Genetic variation perspective reveals potential drug targets for subtypes of endometrial cancer., PMID:39548148
Hepcidin expression is associated with increased γ-secretase-mediated cleavage of neogenin in the liver., PMID:39454953
Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage., PMID:39107268
Netrin-1 Is an Important Mediator in Microglia Migration., PMID:39000184
Transcriptomic analysis of benign prostatic hyperplasia identifies critical pathways in prostatic overgrowth and 5-alpha reductase inhibitor resistance., PMID:38168866
Hepatic Expression of NTN4 and Its Receptors in Patients with Hepatocellular Carcinoma., PMID:38156865
Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers., PMID:37955612
Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling., PMID:37824022
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome., PMID:37212950
Increased Expression Levels of Netrin-1 in Visceral Adipose Tissue during Obesity Favour Colon Cancer Cell Migration., PMID:36831381
Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome., PMID:36797672
Neogenin suppresses tumor progression and metastasis via inhibiting Merlin/YAP signaling., PMID:36746934
Purification and characterization of eukaryotic ATP-dependent transporters homologously expressed in Pichia pastoris for structural studies by cryo-electron microscopy., PMID:36632890
[Bioinformatics Analysis of Hub Genes of Diabetic Foot Ulcer and Their Biofunctions]., PMID:36443035
Netrin-1 Promotes Visceral Adipose Tissue Inflammation in Obesity and Is Associated with Insulin Resistance., PMID:36297056
Exploring whole proteome to contrive multi-epitope-based vaccine for NeoCoV: An immunoinformtics and in-silico approach., PMID:35990651
Effects of Triiodothyronine on Human Osteoblast-Like Cells: Novel Insights From a Global Transcriptome Analysis., PMID:35784485
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies., PMID:35348614
Upregulation of Neogenin-1 by a CREB1-BAF47 Complex in Vascular Endothelial Cells is Implicated in Atherogenesis., PMID:35186922
Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain., PMID:34899198
Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population., PMID:34782459
Structural basis of the P4B ATPase lipid flippase activity., PMID:34645814
Elevated RGMA Expression Predicts Poor Prognosis in Patients with Glioblastoma., PMID:34588781
Netrin-1 as a Multitarget Barrier Stabilizer in the Peripheral Nerve after Injury., PMID:34576252
KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer., PMID:34333552
Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response., PMID:33850017
Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin expression and iron homeostasis in mice., PMID:33824974
Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease-like vasculopathy., PMID:33775822
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling., PMID:33740419
Neogenin is highly expressed in diffuse intrinsic pontine glioma and influences tumor invasion., PMID:33571520
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1., PMID:33504783
Identification of NEO1 as a prognostic biomarker and its effects on the progression of colorectal cancer., PMID:33088218
Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer., PMID:32854720
Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex., PMID:32853179
A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi functions., PMID:32730286
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex., PMID:32576689
Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes., PMID:32417267
Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling., PMID:32231305
Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells., PMID:32042028
Hamster neogenin, a host-cell protein contained in a respiratory syncytial virus candidate vaccine, induces antibody responses in rabbits but not in clinical trial participants., PMID:31951765
Ligands, Receptors, and Transcription Factors that Mediate Inter-Cellular and Intra-Cellular Communication during Ovarian Follicle Development., PMID:31939199
RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy., PMID:31843279
Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae., PMID:31786280
For research use only. Not for human or drug use.
