Catalog No.
YHJ33901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe502-Phe636
Predicted molecular weight
17.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92854
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
A8, Semaphorin-4D, GR3, BB18, SEMAJ, C9orf164, CD100, SEMA4D
Regulation of Vascular Calcification by M1-Type Macrophage-Derived Semaphorin 4D., PMID:40507881
Research Advances in the Immunomodulatory Functions of CD100/SEMA4D and Their Roles in Viral Infectious Diseases., PMID:40362578
Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes., PMID:40121188
Exploring the therapeutic potential of Diosgenin as a Semaphorin-4D antagonist against neurodegenerative disorders., PMID:40015468
Pepinemab: a SEMA4D antagonist for treatment of Huntington's and other neurodegenerative diseases., PMID:40007468
Rectifying the Crosstalk between the Skeletal and Immune Systems Improves Osteoporosis Treatment by Core-Shell Nanocapsules., PMID:39879106
Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization., PMID:39865283
Downregulation of N6-methyladenosine (m6A) methylation of Sema4D mRNA contributes to Treg dysfunction and allograft rejection., PMID:39848338
Soluble CD72 concurrently impairs T cell functions while enhances inflammatory response in sepsis., PMID:39793226
PLXNB1/SEMA4D signals mediate interactions between malignant epithelial and immune cells to promote colorectal cancer liver metastasis., PMID:39443302
Sema4D deficiency enhances glucose tolerance through GLUT2 retention in hepatocytes., PMID:39334386
Zinc Enhances Cadmium Accumulation in Shoots of Hyperaccumulator Solanum nigrum by Improving ATP-Dependent Transport and Alleviating Toxicity., PMID:39274012
Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching., PMID:38821358
Fibroblasts with high matrix metalloproteinase 2 expression regulate CD8+ T-cell residency and inflammation via CD100 in psoriasis., PMID:38752329
Plexin B2 tissue expression and related gene polymorphisms in psoriasis and their relation to NB-UVB and Acitretin therapy., PMID:38734848
A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614)., PMID:38520670
Genome-wide Analysis Identified SEMA4D, Novel Candidate Gene for Temperature Sensitivity in Patients With Non-Small Cell Lung Cancer., PMID:38469817
Soluble Semaphorin 4D Serum Concentrations Are Elevated in Critically Ill Patients with Liver Cirrhosis and Correlate with Aminotransferases., PMID:38396409
Schistosome egg-derived extracellular vesicles deliver Sja-miR-71a inhibits host macrophage and neutrophil extracellular traps via targeting Sema4D., PMID:38129877
Sema4D as a biomarker for Predicting rheumatoid arthritis disease activity., PMID:38097864
Modulation of SEMA4D-modified titanium surface on M2 macrophage polarization via activation of Rho/ROCK-mediated lactate release of endothelial cells: In vitro and in vivo., PMID:38070369
Cholangiocytes Modulate CD100 Expression in the Liver and Facilitate Pathogenic T-Helper 17 Cell Differentiation., PMID:37995866
Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-κB/NLRP3 pathways., PMID:37952827
Comparative evaluation of semaphorin-4D, peptidylarginine deiminase-2, and matrix metalloproteinase-8 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis smoker and non-smoker patients before and after non-surgical periodontal therapy., PMID:37846733
Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression., PMID:37591326
Sema4D is diminished in leukocyte platelet-rich fibrin and impairs pre-osteoblastic MC3T3-E1 cells' functionality., PMID:37572522
Protection of Barrier Function in Cultured Human Corneal Epithelial Cells by Semaphorin 4D., PMID:37395011
Semaphorin 4D Promotes Osteoclast Formation but Inhibits Osteoblast Formation: Implication in Bisphosphonate-Related Osteonecrosis of the Jaw., PMID:37307793
Semaphorin 4D induced inhibitory synaptogenesis decreases epileptiform activity and alters progression to Status Epilepticus in mice., PMID:37163910
The value of serum Sema4D level in predicting the prognosis of patients with acute ST-segment elevation myocardial infarction and with high thrombus burden., PMID:37138227
Sema4D silencing increases the sensitivity of nivolumab to B16-F10 resistant melanoma via inhibiting the PI3K/AKT signaling pathway., PMID:37096066
Impact of leptin or melatonin on Sema4D overexpression-related bone metabolism., PMID:37031174
β-mannanase supplementation in diets reduced in 85 kcal metabolizable energy/kg containing xylanase-phytase improves gain to feed ratio, nutrient usage, and backfat thickness in finisher pigs., PMID:37008356
Transcriptome analysis reveals insight into the protective effect of N-acetylcysteine against cadmium toxicity in Ganoderma lucidum (Polyporales: Polyporaceae)., PMID:36991205
[The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats]., PMID:36970799
Inhibition of the Semaphorin 4D-Plexin-B1 axis prevents calcification in vascular smooth muscle cells., PMID:36443004
Ophthalmic Solution of Smart Supramolecular Peptides to Capture Semaphorin 4D against Diabetic Retinopathy., PMID:36437109
Sema4D-plexin-B1 signaling in recruiting dental stem cells for vascular stabilization on a microfluidic platform., PMID:36331411
Semaphorin 4D induces articular cartilage destruction and inflammation in joints by transcriptionally reprogramming chondrocytes., PMID:36318619
The Potential Immunomodulatory Roles of Semaphorin 4D in Human Periapical Lesions., PMID:36257402
Pepinemab antibody blockade of SEMA4D in early Huntington's disease: a randomized, placebo-controlled, phase 2 trial., PMID:35941373
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity., PMID:35933420
An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis., PMID:35850304
Decreased expression of SEMA4D in recurrent implantation failure induces reduction of trophoblast invasion and migration via the Met/PI3K/Akt pathway., PMID:35816784
SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling., PMID:35794581
MIR4435-2HG, miR-125b-5p, and Sema4D axis affects the aggressiveness of colorectal cancer cells., PMID:35730423
Locally Secreted Semaphorin 4D Is Engaged in Both Pathogenic Bone Resorption and Retarded Bone Regeneration in a Ligature-Induced Mouse Model of Periodontitis., PMID:35628440
γδ T cell costimulatory ligands in antitumor immunity., PMID:35480230
Colorimetric food spoilage monitoring with carbon dot and UV light reinforced fish gelatin films using a smartphone application., PMID:35469948
Soluble Sema4D Level Is Positively Correlated with Sema4D Expression in PBMCs and Peripheral Blast Number in Acute Leukemia., PMID:35401878
For research use only. Not for human or drug use.
