Catalog No.
YHJ32501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln32-Pro350
Predicted molecular weight
36.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q92692
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Herpesvirus entry mediator B, Herpes virus entry mediator B, Nectin cell adhesion molecule 2, HVEB, PVRL2, Poliovirus receptor-related protein 2, CD112, PRR2, Nectin-2, HveB, NECTIN2
Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia., PMID:40425968
ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer., PMID:40371640
Association of Alzheimer's-Related Gene Variants with Autism Spectrum Disorder: A Case-Control Study in an Iraqi Cohort., PMID:40327194
Structure-guided engineering of CD112 receptor variants for optimized immunotherapy., PMID:40285356
Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells., PMID:40274631
Small glycomimetic antagonists of the cytomegalovirus glycoprotein UL141 prevent binding to TRAIL death receptor., PMID:40216247
Co-blocking TIGIT and PVRIG Using a Novel Bispecific Antibody Enhances Antitumor Immunity., PMID:39851063
Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells., PMID:39754720
Chemotherapy induces myeloid-driven spatially confined T cell exhaustion in ovarian cancer., PMID:39658541
Targeting Caveolin-1 in Multiple Myeloma Cells Enhances Chemotherapy and Natural Killer Cell-Mediated Immunotherapy., PMID:39630017
CD34+ and CD34- MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells., PMID:39531203
Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor-Ligand Interactions That Instructs Intratumoral γδT-cell Activity., PMID:39514370
Effect of plasma-induced oxidation on NK cell immune checkpoint ligands: A computational-experimental approach., PMID:39395241
Tumor-associated neutrophils upregulate Nectin2 expression, creating the immunosuppressive microenvironment in pancreatic ductal adenocarcinoma., PMID:39261943
Clinical response and pathway-specific correlates following TIGIT-LAG3 blockade in myeloma: the MyCheckpoint randomized clinical trial., PMID:39187595
Identification of senescent cell subpopulations by CITE-seq analysis., PMID:39143693
Immunological Profiling of CD8+ and CD8- NK Cell Subpopulations and Immune Checkpoint Alterations in Early-Onset Preeclampsia and Healthy Pregnancy., PMID:39125946
Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironment., PMID:39120585
The Immunological Profile of Adipose Mesenchymal Stromal/Stem Cells after Cell Expansion and Inflammatory Priming., PMID:39062566
Increased PVR Expression on Bone Marrow Macrophages May Promote Resistance to TIGIT Blockade in Multiple Myeloma., PMID:38990101
Blockade of the TIGIT-CD155/CD112 axis enhances functionality of NK-92 but not cytokine-induced memory-like NK cells toward CD155-expressing acute myeloid leukemia., PMID:38967649
CD112 is an epithelial-to-mesenchymal transition-related and immunological biomarker in pan-cancer., PMID:38881943
Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling., PMID:38821255
NECTIN2 is a prognostic biomarker and potential therapeutic target in lung adenocarcinoma., PMID:38678829
Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2., PMID:38626767
PVRL2 Suppresses Antitumor Immunity through PVRIG- and TIGIT-independent Pathways., PMID:38588410
CD112 Supports Lymphatic Migration of Human Dermal Dendritic Cells., PMID:38474388
The SNP rs6859 in NECTIN2 gene is associated with underlying heterogeneous trajectories of cognitive changes in older adults., PMID:38408961
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death., PMID:38211590
Astragalus Polysaccharide Alleviates Ulcerative Colitis by Regulating the Balance of mTh17/mTreg Cells through TIGIT/CD155 Signaling., PMID:38202824
Intensified NK cell therapy in combination with low-dose chemoradiotherapy against human colorectal cancer., PMID:37801126
Immune checkpoint molecule DNAM-1/CD112 axis is a novel target for natural killer-cell therapy in acute myeloid leukemia., PMID:37731380
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer., PMID:37728201
Single-cell RNA sequencing highlights the role of PVR/PVRL2 in the immunosuppressive tumour microenvironment in hepatocellular carcinoma., PMID:37383234
Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia., PMID:37378949
Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the PVRL2 Gene as a New Modulator of Diabetic Dyslipidemia., PMID:37108578
Nectin2 influences cell apoptosis by regulating ANXA2 expression in neuroblastoma., PMID:36916296
CD8 and CD4 Positive NKT Subpopulations and Immune-Checkpoint Pathways in Early-Onset Preeclampsia and Healthy Pregnancy., PMID:36674905
Extracellular CIRP Induces Novel Nectin-2+ (CD112+) Neutrophils to Promote Th1 Differentiation in Sepsis., PMID:36480269
Bone marrow mesenchymal stem cells regulate the dysfunction of NK cells via the T cell immunoglobulin and ITIM domain in patients with myelodysplastic syndromes., PMID:36303184
Examination of the TIGIT-CD226-CD112-CD155 Immune Checkpoint Network during a Healthy Pregnancy., PMID:36142692
DNAM-1-chimeric receptor-engineered NK cells, combined with Nutlin-3a, more effectively fight neuroblastoma cells in vitro: a proof-of-concept study., PMID:35967339
Emergence of the CD226 Axis in Cancer Immunotherapy., PMID:35812451
TgMab-2: An Anti-human T Cell Immunoglobulin and Immunoreceptor Tyrosine-Based Inhibitory Motif Domain Monoclonal Antibody for Immunocytochemistry., PMID:35736625
Inhibitory Immune Checkpoint Receptors and Ligands as Prognostic Biomarkers in COVID-19 Patients., PMID:35432324
Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study., PMID:35093267
Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B., PMID:35062364
Gene of the month: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT)., PMID:35058314
DNAM-1 versus TIGIT: competitive roles in tumor immunity and inflammatory responses., PMID:34694361
DNAM-1 promotes inflammation-driven tumor development via enhancing IFN-γ production., PMID:34672321
For research use only. Not for human or drug use.
