Catalog No.
YHJ30601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys332-Gln583
Predicted molecular weight
30.68 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WWW8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Growth factor receptor bound protein 2-associated protein 3, GRB2-associated-binding protein 3, GRB2-associated binder 3, GAB3
The "DDVF" motif used by viral and bacterial proteins to hijack RSK kinases mimics a short linear motif (SLiM) found in proteins related to the RAS-ERK MAP kinase pathway., PMID:40153681
Genetic susceptibility to essential hypertension in the Chinese han population: a study on GAB1, GAB2, and GAB3 gene polymorphisms., PMID:40140746
In Search of a Target Gene for a Desirable Phenotype in Aquaculture: Genome Editing of Cyprinidae and Salmonidae Species., PMID:38927661
High expression of GRB2 associated binding protein 3 mRNA predicts positive prognosis in melanoma., PMID:36545920
Identification of a six-gene prognostic signature for bladder cancer associated macrophage., PMID:36275756
Nanoparticle Contrast-enhanced MRI for Visualization of Retroplacental Clear Space Disruption in a Mouse Model of Placental Accreta Spectrum (PAS)., PMID:36167627
Identification of Grb2-associated binding protein 3 expression to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma., PMID:35822560
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells., PMID:33763075
Identification of a ceRNA Network in Lung Adenocarcinoma Based on Integration Analysis of Tumor-Associated Macrophage Signature Genes., PMID:33738286
GAB2 and GAB3 are expressed in a tumor stage-, grade- and histotype-dependent manner and are associated with shorter progression-free survival in ovarian cancer., PMID:32888136
Characterization of GAB3 and its association with NNV resistance in the Asian seabass., PMID:32473363
G-CSF-dependent neutrophil differentiation requires downregulation of MAPK activities through the Gab2 signaling pathway., PMID:32437087
Identification of PtdIns(3,4)P2 effectors in human platelets using quantitative proteomics., PMID:31743753
Placentation and antitumor immunity regulated by a scaffolding protein in NK cells., PMID:31375527
Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy., PMID:31375526
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation., PMID:30936879
Regulation of antitumor miR-144-5p targets oncogenes: Direct regulation of syndecan-3 and its clinical significance., PMID:29968393
Interferon down-regulation of miR-1225-3p as an antiviral mechanism through modulating Grb2-associated binding protein 3 expression., PMID:29496996
Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?, PMID:28334935
Gab3 overexpression in human glioma mediates Akt activation and tumor cell proliferation., PMID:28291820
Gab3 is required for human colorectal cancer cell proliferation., PMID:28115166
Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes., PMID:27025927
[Structure and function of the adapter protein Gab and its role in the development of tumor, inflammation and cardiovascular diseases]., PMID:26915323
Gab1 Is Modulated by Chronic Hypoxia in Children with Cyanotic Congenital Heart Defect and Its Overexpression Reduces Apoptosis in Rat Neonatal Cardiomyocytes., PMID:26090437
Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis., PMID:25528308
Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans., PMID:25224454
Gab docking proteins in cardiovascular disease, cancer, and inflammation., PMID:23431498
Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology., PMID:22163099
Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-met signaling., PMID:21293003
Informativeness of a novel multiallelic marker-set comprising an F8 intron 21 and three tightly linked loci for haemophilia A carriership analysis., PMID:21070487
[New efficient extragenic microsatellite markers for hemophilia A carrier state diagnostics]., PMID:17853810
The multiple function of Grb2 associated binder (Gab) adaptor/scaffolding protein in immune cell signaling., PMID:16386802
Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor., PMID:15952937
The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions., PMID:15240750
Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent., PMID:12640125
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation., PMID:11997510
The gift of Gab., PMID:11943184
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation., PMID:11739737
For research use only. Not for human or drug use.
