Catalog No.
YHJ30101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe62
Predicted molecular weight
33.65 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WWG1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pro-neuregulin-4, membrane-bound isoform, Pro-NRG4, NRG4, NRG-4
Neuregulin 4: A Key Regulator in Suppressing Lung Adenocarcinoma Progression., PMID:40405680
Brown adipose tissue alleviates podocyte apoptosis through NRG4 in a male mouse model of diabetic kidney disease., PMID:40014139
Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling., PMID:39891907
The Putative Antilipogenic Role of NRG4 and ERBB4: First Expression Study on Human Liver Samples., PMID:39735994
Neuregulin 4 attenuates pancreatic β-cell apoptosis induced by lipotoxicity via activating mTOR-mediated autophagy., PMID:39541216
Neuregulin 4 Downregulation Alters Mitochondrial Morphology and Induces Oxidative Stress in 3T3-L1 Adipocytes., PMID:39519269
Neuregulin-4 alleviates isoproterenol (ISO)-induced cardial remodeling by inhibiting inflammation and apoptosis via AMPK/NF-κB pathway., PMID:39418729
Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease., PMID:39333727
Can Bone Morphogenetic Protein 1 (BMP1) Be a Potential Biomarker of Obesity?, PMID:39280566
Low circulating levels of neuregulin 4 as a potential biomarker associated with the severity and prognosis of obesity-related metabolic diseases: a systematic review., PMID:39162358
The Causal Effect of Serum Lipid Levels Mediated by Neuregulin 4 on the Risk of Four Atherosclerosis Subtypes: Evidence from Mendelian Randomization Analysis., PMID:39104661
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway., PMID:39095871
Neuregulin 4 Attenuates Podocyte Injury and Proteinuria in Part by Activating AMPK/mTOR-Mediated Autophagy in Mice., PMID:39091188
Renal denervation alleviates vascular remodeling in spontaneously hypertensive rats by regulating perivascular adipose tissue., PMID:39043918
A comparison of brown fat tissue related hormone levels in metabolically healthy and unhealthy individuals with obesity., PMID:39008201
Neuregulin4-ErbB4 signalling pathway is driven by electroacupuncture stimulation to remodel brown adipose tissue innervation., PMID:38951947
The browning and mobilization of subcutaneous white adipose tissue supports efficient skin repair., PMID:38838641
Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction., PMID:38823457
Lipid metabolic reprogramming mediated by circulating Nrg4 alleviates metabolic dysfunction-associated steatotic liver disease during the early recovery phase after sleeve gastrectomy., PMID:38632600
Neuregulin 4 in Polycystic Ovarian Syndrome (PCOS) Phenotypes: A Key Role or Standby., PMID:38618267
Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL expression via ErbB4/Erk signaling pathway as a potential prolactin (PRL) regulator., PMID:38465779
Metastatic Lymph Node 64 (MLN64) Expression in Gastric Cancer: The Clinical and Molecular Implications in Drug Resistance., PMID:38151289
Effects of oleoylethanolamide supplementation on the expression of lipid metabolism-related genes and serum NRG4 levels in patients with non-alcoholic fatty liver disease: A randomized controlled trial., PMID:38057021
Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis., PMID:38015639
Changes in brown adipose tissue induced by resveratrol and its analogue pterostilbene in rats fed with a high-fat high-fructose diet., PMID:37843714
[Electroacupuncture intervention improves lipid metabolism and promotes browning of white adipose tissue by activating AMPK/Sirt1 pathway and up-regulating Nrg4 content in middle-aged and aged obese rats]., PMID:37614134
The relationship of circulating neuregulin 4 and irisin, and traditional and novel cardiometabolic risk factors with the risk and severity of coronary artery disease., PMID:37591135
Investigation of time-dependent alterations in adipokine levels and endoplasmic reticulum stress markers in obese patients with laparoscopic sleeve gastrectomy., PMID:37541576
NGR4 and ERBB4 as Promising Diagnostic and Therapeutic Targets for Metabolic Disorders., PMID:37369570
Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis., PMID:37265326
"Turning up the heat": role of neurotrophic batokines in the postnatal maturation and remodeling of brown adipose tissue in deer mice., PMID:37224469
Characterization of the genomic and transcriptional structure of chicken NRG4 gene., PMID:37194591
Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis., PMID:37060105
Correlation of asprosin and Nrg-4 with type 2 diabetes Mellitus Complicated with Coronary Heart Disease and the Diagnostic Value., PMID:36915073
Effect of a collagen-enriched beverage with or without omega-3 fatty acids on wound healing, metabolic biomarkers, and adipokines in patients with major burns., PMID:36724726
Disease progression promotes changes in adipose tissue signatures in type 2 diabetic (db/db) mice: The potential pathophysiological role of batokines., PMID:36521548
Brown adipose tissue-derived Nrg4 alleviates endothelial inflammation and atherosclerosis in male mice., PMID:36400933
Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway., PMID:36221104
Serum neuregulin 4 is negatively correlated with insulin sensitivity in humans and impairs mitochondrial respiration in HepG2 cells., PMID:36187779
Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment., PMID:35973424
Cardioprotective effect of NRG-4 gene expression on spontaneous hypertension rats and its mechanism through mediating the activation of ErbB signaling pathway., PMID:35809324
Neuregulin 4 (NRG4) - the hormone with clinical significance in gestational diabetes mellitus., PMID:35603674
Nobiletin and 3'-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation., PMID:35370279
Effect of metformin as an add-on therapy on neuregulin-4 levels and vascular-related complications in adolescents with type 1 diabetes: A randomized controlled trial., PMID:35351535
Comparison of maternal serum NRG-4 levels in healthy and preeclamptic pregnancies., PMID:35263833
Effects of voluntary exercise on the expression of browning markers in visceral and subcutaneous fat tissue of normotensive and spontaneously hypertensive rats., PMID:34893937
Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles., PMID:34884763
Alteration of serum neuregulin 4 and neuregulin 1 in gestational diabetes mellitus., PMID:34646438
[Molecular mechanism of Gegen Qinlian Decoction in promoting differentiation of brown adipose tissue to improve glucose and lipid metabolism disorders in diabetic rats]., PMID:34581051
Effects of serum irisin, neuregulin 4, and weight management on obese adolescent girls with polycystic ovary syndrome., PMID:34427289
For research use only. Not for human or drug use.
