Catalog No.
YHJ28301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp1722-Asn1905
Predicted molecular weight
23.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8TDM6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Discs large protein P-dlg, Disks large homolog 5, KIAA0583, Placenta and prostate DLG, DLG5, PDLG
Discovering Novel Biomarkers and Potential Therapeutic Targets of Amyotrophic Lateral Sclerosis Through Integrated Machine Learning and Gene Expression Profiling., PMID:40304918
Identification of Oncogenic Alterations in 124 Cases of Pediatric Papillary Thyroid Carcinoma: BEND7::ALK, DLG5::RET, and CCDC30::ROS1 Fusions Induce MAPK Pathway Activation., PMID:39982551
Correlation analysis of DLG5 and PD-L1 expression in triple-negative breast cancer., PMID:39780116
CDK5 interacts with MST2 and modulates the Hippo signalling pathway., PMID:39739588
Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway., PMID:39529470
Exploring a distinct FGFR2::DLG5 rearrangement in a low-grade neuroepithelial tumor: A case report and mini-review of protein fusions in brain tumors., PMID:38833313
LncRNA DLG5-AS1 facilitates breast cancer cell proliferation and invasion by promoting EZH2-mediated transcriptional silencing of SFRP1., PMID:38677505
RETRACTED: Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment., PMID:38622820
Detection of the effect of microvibrational stimulation on human discarded immature oocytes by single-cell transcriptome sequencing technology., PMID:37273164
A double-edged sword: DLG5 in diseases., PMID:37001186
Expression, regulating mechanism and therapeutic target of KIF20A in multiple cancer., PMID:36798768
Epigenomic and transcriptomic landscaping unraveled candidate repositioned therapeutics for non-functioning pituitary neuroendocrine tumors., PMID:36306107
Transcriptional targets of amyotrophic lateral sclerosis/frontotemporal dementia protein TDP-43 - meta-analysis and interactive graphical database., PMID:35946434
Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma., PMID:35638431
Identification of Potential Biomarkers and Small Molecule Drugs for Cutaneous Melanoma Using Integrated Bioinformatic Analysis., PMID:35433681
Breaking the DLG shackles in glioblastoma., PMID:35403688
Variants in genes related to development of the urinary system are associated with Mayer-Rokitansky-Küster-Hauser syndrome., PMID:35361250
The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells., PMID:34984467
A single-cell and spatially resolved atlas of human breast cancers., PMID:34493872
A concise review on the role of BDNF-AS in human disorders., PMID:34426254
Long non-coding RNA TPTEP1 exerts inhibitory effects on hepatocellular carcinoma by impairing microRNA-454-3p-mediated DLG5 downregulation., PMID:34238665
Pembrolizumab for refractory primary mediastinal B-cell lymphoma with central nervous system involvement., PMID:33369766
DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes., PMID:32631816
Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster., PMID:32552730
PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay., PMID:32015336
The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis., PMID:31856229
β-TrCP-mediated ubiquitination and degradation of Dlg5 regulates hepatocellular carcinoma cell proliferation., PMID:31787846
Novel significant stage-specific differentially expressed genes in hepatocellular carcinoma., PMID:31277598
A homozygous frameshift variant in an alternatively spliced exon of DLG5 causes hydrocephalus and renal dysplasia., PMID:30791088
Single Nucleotide Polymorphisms in Selected Genes in Inflammatory Bowel Disease., PMID:30648106
DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression., PMID:30450766
Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase., PMID:30266825
Genetic alterations of 9p24 in lymphomas and their impact for cancer (immuno-)therapy., PMID:30132131
Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion., PMID:29369778
Insight into the molecular mechanism of miR-192 regulating Escherichia coli resistance in piglets., PMID:29363554
Genomic Alterations in Fatal Forms of Non-Anaplastic Thyroid Cancer: Identification of MED12 and RBM10 as Novel Thyroid Cancer Genes Associated with Tumor Virulence., PMID:28634282
Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5., PMID:28390157
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway., PMID:28169360
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2., PMID:28087714
Expression of DLG1 and DLG5 in the Intestinal Epithelium of Patients with CD., PMID:27760079
Meta-analysis of associations between DLG5 R30Q and P1371Q polymorphisms and susceptibility to inflammatory bowel disease., PMID:27633114
Analysis of the Differentiation of Kenyon Cell Subtypes Using Three Mushroom Body-Preferential Genes during Metamorphosis in the Honeybee (Apis mellifera L.)., PMID:27351839
The association of DLG5 polymorphisms with inflammatory bowel disease: a meta-analysis of 25 studies., PMID:27338058
Discs Large Homolog 5 (DLG5) Gene Polymorphism and Crohn's Disease: A Meta-Analysis of the Published Studies., PMID:27309475
Dlg5 maintains apical polarity by promoting membrane localization of Crumbs during Drosophila oogenesis., PMID:27211898
Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma., PMID:26898345
Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization., PMID:25795662
Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5., PMID:25644602
Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis., PMID:25478998
Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization., PMID:25232112
For research use only. Not for human or drug use.
