Catalog No.
YHJ26601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val130-Asp622
Predicted molecular weight
58.05 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NI17
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-31RA, Interleukin-31 receptor subunit alpha, IL31RA, hGLM-R, ZcytoR17, IL-31R-alpha, GPL, CRL3, Cytokine receptor-like 3, IL-31R subunit alpha, IL-31 receptor subunit alpha, Gp130-like receptor, GLM-R, Gp130-like monocyte receptor
Evaluation of pruritus biomarkers expression in chronic spontaneous urticaria., PMID:40261414
Pre- and Postnatal Development Study of Nemolizumab, a Humanized Anti-Interleukin-31 Receptor A Monoclonal Antibody, in Cynomolgus Monkey., PMID:39868832
Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome., PMID:39847438
TIA1-Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL-31RA Signaling., PMID:39804990
COMPREHENSIVE CHARACTERIZATION OF CYTOKINES IN PATIENTS UNDER EXTRACORPOREAL MEMBRANE OXYGENATION: EVIDENCE FROM INTEGRATED BULK AND SINGLE-CELL RNA SEQUENCING DATA USING MULTIPLE MACHINE LEARNING APPROACHES., PMID:39503329
Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro., PMID:39170490
Cytokines and chemokines skin gene expression in correlation with immune cells in blood and severity in equine insect bite hypersensitivity., PMID:39076967
A case of bullous pemphigoid following administration of anti-IL-31 receptor A antibody., PMID:38507442
Prurigo nodularis: new insights into pathogenesis and novel therapeutics., PMID:38345154
Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma., PMID:38081868
Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching., PMID:38035099
Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice., PMID:38003738
Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis., PMID:37888917
IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis., PMID:37831760
Methotrexate for refractory adult atopic dermatitis leads to alterations in cutaneous IL-31 and IL-31RA expression., PMID:37730501
IL-31RA and TRPV1 Expression in Atopic Dermatitis Induced with Trinitrochlorobenzene in Nc/Nga Mice., PMID:37686326
Canine interleukin-31 binds directly to OSMRβ with higher binding affinity than to IL-31RA., PMID:37588794
Analyzing the Antinociceptive Effect of Interleukin-31 in Mice., PMID:37511321
Divergent in situ expression of IL-31 and IL-31RA between bullous pemphigoid and pemphigus vulgaris., PMID:37260420
[Pharmacological profiles and clinical findings of nemolizumab as treatment for pruritus associated with atopic dermatitis]., PMID:37121713
Transcription of interleukin 31 and its receptor by leukocytes after Culicoides sp stimulation is dose dependent but is not exaggerated in allergic horses or correlated with pruritus., PMID:37116871
Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis., PMID:36674561
IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?, PMID:36651089
A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine/chemokine activity in OVA-induced asthmatic mice., PMID:35905568
Nemolizumab: First Approval., PMID:35834124
A genome-wide association study on frequent exacerbation of asthma depending on smoking status., PMID:35606283
Nemolizumab for atopic dermatitis., PMID:35412530
The emerging role of the neuroimmune cytokine interleukin-31 in chronic inflammatory skin diseases., PMID:35274883
Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells., PMID:35111166
A New Era with the Development of Cytokine-Based Therapy for Pruritus., PMID:34801247
IL-31 and IL-31 receptor expression in acute experimental canine atopic dermatitis skin lesions., PMID:34796564
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis., PMID:34642338
Cytokine expression in feline allergic dermatitis and feline asthma., PMID:34519120
The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development., PMID:34491348
Efficacy and Safety of Nemolizumab for Treatment of Adult Atopic Dermatitis: A Meta-analysis of Randomized Clinical Trials., PMID:33876738
The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis., PMID:33815402
Anti-pruritic effect of nemolizumab in hemodialysis patients with uremic pruritus: a phase II, randomized, double-blind, placebo-controlled clinical study., PMID:33754202
Complete Freund's adjuvant-induced decrement of pruriceptor-mediated suppression of itch., PMID:33693534
Interleukin-31: The "itchy" cytokine in inflammation and therapy., PMID:33629401
Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta., PMID:33428793
Biologics for Atopic Dermatitis., PMID:33012322
IL-31 induces antitumor immunity in breast carcinoma., PMID:32843492
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching., PMID:32673566
IL-31 transgenic mice show reduced allergen-induced lung inflammation., PMID:32648940
Increased expression of in situ IL-31RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL-31 family in the pathogenesis of the disease., PMID:32531145
Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA., PMID:32459958
Interleukin-31 promotes pathogenic mechanisms underlying skin and lung fibrosis in scleroderma., PMID:32365362
The cellular basis of protease-activated receptor 2-evoked mechanical and affective pain., PMID:32352932
miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer., PMID:31875548
A novel oncostatin M/interleukin-31 receptor mutation in familial primary localized cutaneous amyloidosis., PMID:31478212
For research use only. Not for human or drug use.
