Catalog No.
EHJ26301
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Glu259
Predicted molecular weight
29.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NHJ6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD85 antigen-like family member K, LIR-5, Leukocyte immunoglobulin-like receptor 5, ILT3, ILT-3, Immunoglobulin-like transcript 3, LILRB4, CD85k, Leukocyte immunoglobulin-like receptor subfamily B member 4, Monocyte inhibitory receptor HM18, LIR5
Presence of LILRB4 SNP rs1048801 modulates acute myeloid leukemia progression and inhibits CD4+ T cells proliferation., PMID:40275747
Polymorphisms in immunosuppression-related genes are associated with AML., PMID:39975548
Immunoglobulin-like transcript 5 polarizes M2-like tumor-associated macrophages for immunosuppression in non-small cell lung cancer., PMID:39910654
LILRB4 as a novel immunotherapeutic target for multiple diseases., PMID:39842553
A Switch Protein Adapter for Anti-LILRB4 CAR-T Cells., PMID:39663681
NLRP12/C1qA positive feedback in tumor-associated macrophages regulates immunosuppression through LILRB4/NF-κB pathway in lung adenocarcinoma., PMID:39527158
Tumor-Derived Immunoglobulin-Like Transcript 4 Promotes Postoperative Relapse via Inducing Vasculogenic Mimicry through MAPK/ERK Signaling in Hepatocellular Carcinoma., PMID:39233275
LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway., PMID:39025844
Leukocyte immunoglobulin-like receptor B4 (LILRB4) in acute myeloid leukemia: From prognostic biomarker to immunotherapeutic target., PMID:38973293
LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway., PMID:38951916
LILRB4 represents a promising target for immunotherapy by dual targeting tumor cells and myeloid-derived suppressive cells in multiple myeloma., PMID:38813706
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model., PMID:38569016
LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets., PMID:38397424
ILT2 and ILT4 Drive Myeloid Suppression via Both Overlapping and Distinct Mechanisms., PMID:38393969
Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection., PMID:38324114
Modelling acquired resistance to DOT1L inhibition exhibits the adaptive potential of KMT2A-rearranged acute lymphoblastic leukemia., PMID:37740239
LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection., PMID:37461040
Prognostic impact of LILRB4 expression on tumor-infiltrating cells in resected non-small cell lung cancer., PMID:37290427
Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing., PMID:37276129
Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B., PMID:37083755
A Case of Acute Mixed Cell Leukemia Resembling AML1-ETO Positive Acute Myeloid Leukemia., PMID:37057942
Comprehensive analysis of LILR family genes expression and tumour-infiltrating immune cells in early-stage pancreatic ductal adenocarcinoma., PMID:36748687
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein., PMID:35967447
Vitamin D-Dimer: A Possible Biomolecule Modulator in Cytotoxic and Phagocytosis Processes?, PMID:35892685
Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface., PMID:35691913
Myeloid immune checkpoint ILT3/LILRB4/gp49B can co-tether fibronectin with integrin on macrophages., PMID:35689642
Analysis of the expression and prognosis for leukocyte immunoglobulin-like receptor subfamily B in human liver cancer., PMID:35321724
Biomimetic design of inhibitors of immune checkpoint LILRB4., PMID:34963077
Protein Arginine Methyltransferase 5 Promotes the Migration of AML Cells by Regulating the Expression of Leukocyte Immunoglobulin-Like Receptor B4., PMID:34712735
The Fibronectin-ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells., PMID:34426457
Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation., PMID:34425800
Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma., PMID:34098344
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice., PMID:34089617
LILRB4 suppresses immunity in solid tumors and is a potential target for immunotherapy., PMID:33974041
CD85k Contributes to Regulatory T Cell Function in Chronic Viral Infections., PMID:33375121
ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells., PMID:33372059
Suppression of Experimental Autoimmune Encephalomyelitis by ILT3.Fc., PMID:33361206
The association of leukocyte immunoglobulin-like receptor subfamily B-4 expression in acute myeloid leukemia and central nervous system involvement., PMID:33285315
ILT3 promotes tumor cell motility and angiogenesis in non-small cell lung cancer., PMID:33152402
Leukocyte immunoglobulin-like receptor B1 and B4 (LILRB1 and LILRB4): Highly sensitive and specific markers of acute myeloid leukemia with monocytic differentiation., PMID:32918786
LILRB4-targeting Antibody-Drug Conjugates for the Treatment of Acute Myeloid Leukemia., PMID:32879051
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion., PMID:32531268
Combining bioinformatics and biological detection to identify novel biomarkers for diagnosis and prognosis of pulmonary tuberculosis., PMID:32291421
LILRB4 expression in chronic myelomonocytic leukemia and myelodysplastic syndrome based on response to hypomethylating agents., PMID:32036728
Frequency of dendritic cell subsets and ILT3, ILT4 gene expression in two different immunosuppressive protocols in kidney transplant recipients. A cohort report., PMID:31833032
Synergistic Effects of Interferon-γ and Vitamin D3 Signaling in Induction of ILT-3highPDL-1high Tolerogenic Dendritic Cells., PMID:31798578
LILRB4 ITIMs mediate the T cell suppression and infiltration of acute myeloid leukemia cells., PMID:31700117
Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development., PMID:31213474
Leukocyte immunoglobulin-like receptor B4 deficiency exacerbates acute lung injury via NF-κB signaling in bone marrow-derived macrophages., PMID:31138763
Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute Phase of Kawasaki Disease., PMID:30882741
For research use only. Not for human or drug use.
