Catalog No.
YHJ24401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val51-Thr233
Predicted molecular weight
23.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NE86
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HsMCU, Calcium uniporter protein, mitochondrial, C10orf42, CCDC109A, Coiled-coil domain-containing protein 109A, MCU
Phospho-CREB regulation on NMDA glutamate receptor 2B and mitochondrial calcium uniporter in the ventrolateral periaqueductal gray controls chronic morphine withdrawal in male rats., PMID:40494620
Structural and functional characterization of the cardiac mitochondria-associated reticular membranes in the ob/ob mouse model., PMID:40492240
Impact of PARL-mediated mitochondrial protease activity on calcium regulation., PMID:40484322
[Study on mechanism of naringin in alleviating cerebral ischemia/reperfusion injury based on DRP1/LRRK2/MCU axis]., PMID:40461204
Mitochondrial Calcium Uniporter is Required for Thermogenic Adaptation Mediated by Reactive Oxygen Species Signaling., PMID:40449733
Hyperoside alleviates zearalenone-induced liver injury by regulating mitochondrial calcium overload mediated excessive autophagy., PMID:40440910
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma., PMID:40435263
Mitochondrial Calcium Uniporter (MCU)-Mediated Calcium Overload in Psychoactive Drug Neurotoxicity: From Pathogenesis to Therapeutic Targets., PMID:40429873
Genetic Predisposition and Mitochondrial Dysfunction in Sudden Cardiac Death: Role of MCU Complex Genetic Variations., PMID:40422231
Mitochondrial calcium homeostasis mediated by estradiol contributes to atrial fibrillation protection., PMID:40414005
Structure of MICU from non-metazoan Dictyostelium discoideum reveals unique characteristics., PMID:40399431
MCU regulating bone remodeling and osteogenic function through mitochondrial calcium homeostasis and oxidative stress alteration., PMID:40389181
Mitochondrial calcium overload contributes to mechanical allodynia in neuropathic pain via inducing mitochondrial dynamic imbalance., PMID:40359888
MICU1 is the nexus for CaV3.3 regulation of mitochondrial calcium, redox balance and chondrocyte viability., PMID:40354861
Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity., PMID:40286270
Mechanism of MCUB-Dependent Inhibition of Mitochondrial Calcium Uptake., PMID:40227803
Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload., PMID:40205506
The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration., PMID:40191272
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis., PMID:40188890
Effects of aging on calcium channels in skeletal muscle., PMID:40177518
Diquat exposure causes brainstem demyelination by upregulating the mitochondrial calcium uniporter., PMID:40163990
Multiple Inhibitory Mechanisms of DS16570511 Targeting Mitochondrial Calcium Uptake: Insights from Biochemical Analysis of Rat Liver Mitochondria., PMID:40141312
Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB., PMID:40118824
Effects of a mitochondrial calcium uniporter and P-selectin inhibitors on neural injury induced by global cerebral ischemia-reperfusion in male rats., PMID:40085331
Enhancement of mitochondrial calcium uptake is cardioprotective against maladaptive hypertrophy by retrograde signaling uptuning Akt., PMID:40067892
Mitochondrial Ca2+ uniporter b (MCUb) regulates neuronal Ca2+ dynamics and resistance to ischemic stroke., PMID:40058292
Exploring different mechanisms of reactive oxygen species formation in hypoxic conditions at the hippocampal CA3 area., PMID:40054836
SARM1 Modulates calcium influx in secondary brain injury after experimental Intracerebral hemorrhage., PMID:40021079
Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb., PMID:40017731
The Noncanonical Wnt5a-Ca2+ Pathway Mediates Mitochondrial Dysfunction in the Progression of Diabetic Nephropathy via the Mitochondrial Calcium Uniporter., PMID:40008536
Sirtuin-1 Regulates Mitochondrial Calcium Uptake Through Mitochondrial Calcium Uptake 1 (MICU1)., PMID:40003583
Oleuropein Supplementation Increases Resting Skeletal Muscle Fractional Pyruvate Dehydrogenase Activity but Does Not Influence Whole-Body Metabolism: A Randomized, Double-Blind, and Placebo-Controlled Trial in Healthy, Older Males., PMID:39993475
Targeting the HDAC6/Hint2/MICU1 axis to ameliorate acute liver failure via inhibiting NETosis., PMID:39983829
PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2., PMID:39983639
Fluoride induces spermatocyte apoptosis by IP3R1/MCU-mediated mitochondrial calcium overload through MAMs., PMID:39929132
Mitochondria-targeting siRNA screening identifies mitochondrial calcium uniporter as a factor involved in nucleoid morphology., PMID:39928408
Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU-EMRE Assembly., PMID:39921279
MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity., PMID:39915602
Mitochondrial Calcium Uniporter knockdown improves the viability of HT22 hippocampal neurons in Alzheimer's disease., PMID:39914782
TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes., PMID:39905300
Proteomic analysis reveals QiShenYiQi Pills ameliorates ischemia-induced heart failure through inhibition of mitochondrial fission., PMID:39892313
Regulation of calcium signaling prevents neuronal death mediated by NIST DEP in xenoferroptotic cell death conditions., PMID:39892142
Protective role of vitamin D receptor against mitochondrial calcium overload from PM2.5-Induced injury in renal tubular cells., PMID:39891958
MCU-i4, a mitochondrial Ca2+ uniporter modulator, induces breast cancer BT474 cell death by enhancing glycolysis, ATP production and reactive oxygen species (ROS) burst., PMID:39866241
Mechanisms of dual modulatory effects of spermine on the mitochondrial calcium uniporter complex., PMID:39863104
Mitochondrial calcium homeostasis and atrial fibrillation: Mechanisms and therapeutic strategies review., PMID:39828107
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation., PMID:39804926
Modulatory roles of capsaicin on thermogenesis in C2C12 myoblasts and the skeletal muscle of mice., PMID:39800145
A novel super-resolution STED microscopy analysis approach to observe spatial MCU and MICU1 distribution dynamics in cells., PMID:39765273
Mitochondrial calcium uniporter complex: An emerging therapeutic target for cardiovascular diseases (Review)., PMID:39749702
For research use only. Not for human or drug use.
