Catalog No.
YHJ23501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met76-Lys211
Predicted molecular weight
17.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8NAU1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FRCP2, Fibronectin type III repeat-containing protein 2, Fibronectin type III domain-containing protein 5, FNDC5
Physiological and psychological responses to five-day fasting., PMID:40479627
Gestational fish oil supplementation in high-fat diet induces sex-specific myokine changes in weanling offspring., PMID:40459971
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis., PMID:40455667
Irisin and its role in the reproductive physiology: a review., PMID:40435081
The Association Between Myokines, Inflammation, and Nutritional Status in Patients with Multiple Sclerosis., PMID:40427596
Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative Diseases., PMID:40427436
Potential effect of Irisin on sarcopenia: a systematic review., PMID:40420047
Investigating Anti-Tumor Effects of Irisin in Cervical Cancer Cells: Cell Viability, Migration, and Tumor-Associated Macrophage Polarization., PMID:40415369
The therapeutic potential of irisin in alleviating acute lung injury via inflammation and ferroptosis modulation., PMID:40406908
Examination of hemorheological and exerkine concentrations at four-week whole body vibration exercise in obese women: A pilot study., PMID:40392016
Muscle-derived factor alleviated cognitive impairment caused by intestinal ischemia-reperfusion., PMID:40388874
Cardiovascular System is Influenced by Skeletal Muscle-derived Extracellular Vesicles, Myokines and MicroRNAs Based on Interorgan Communication: A Systematic Review., PMID:40386050
Clinical significance of serum irisin, 25(OH)D3 and albumin in older adults with chronic disease and sarcopenia., PMID:40377817
From Skeletal Muscle to Myocardium: Molecular Mechanisms of Exercise-Induced Irisin Regulation of Cardiac Fibrosis., PMID:40332022
Are breast milk and serum irisin levels affected by the BMI and nutritional status? A prospective observational study., PMID:40325267
Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling., PMID:40320408
Irisin Is a Potential Novel Biomarker and Therapeutic Target Against Kidney Diseases., PMID:40318104
High Serum Levels of Irisin, Visfatin and Adiponectin as Potential Independent Risk Factors for Diabetic Nephropathy Progression in Patients With Type 2 Diabetes Mellitus., PMID:40294981
Keto Acids Attenuate Skeletal Muscle Atrophy in Chronic Kidney Disease via Inhibiting Pyroptosis and Upregulating Irisin Precursor FNDC5 Expression., PMID:40272551
Systemic effect of combined functional overload and endurance-type swimming exercise on whole body metabolism in mice., PMID:40248969
Cytokine response to resistance exercise in children with excess adiposity and Prader-Willi syndrome., PMID:40243109
Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity., PMID:40241040
Irisin and its role in fracture healing: A comparative study with hyaluronic acid and platelet-rich plasma in a rat model., PMID:40235411
Effect of regular exercise on ocular inflammation and mitochondrial biogenesis in experimental Alzheimer's disease model., PMID:40235325
Transcriptional Intermediary Factor 1γ-Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy., PMID:40235186
Physical activity in Alzheimer's disease prevention: Sex differences and the roles of BDNF and irisin., PMID:40228745
Consecutive skeletal muscle PGC-1α overexpression: A double-edged sword for mitochondrial health in the aging brain., PMID:40228677
Persian Gulf brown seaweed extracts showing anti-obesity potency on adipogenic differentiation in human adipose-derived mesenchymal stem cells and obese male rats., PMID:40222851
Irisin Regulates Microglia M1/M2 Polarization and Promotes Autophagy Through the Sirt3 Pathway to Alleviate POCD., PMID:40214830
Acute effects of high-intensity interval exercise plus whole-body vibration on bone turnover markers, BDNF, irisin, and neurocognitive performance in postmenopausal women., PMID:40209895
Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway., PMID:40192010
Irisin Alleviates Impaired Mitochondrial Fusion via Enhancing PKA/SIRT3/mTOR Pathway in Hepatic Steatosis., PMID:40170593
The Complex Interplay of Irisin Levels, Low Birth Weight, and Blood Pressure in Prepubescent Children., PMID:40165348
Irisin prevents visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome., PMID:40154794
The Regulatory Effects of Exercise and Metformin on Biomarkers in Obesity: A Focus on Uric Acid, Irisin, Adiponutrin, Adropin, and Copeptin., PMID:40142210
Effects of Different Intensities of Endurance Training on Neurotrophin Levels and Functional and Cognitive Outcomes in Post-Ischaemic Stroke Adults: A Randomised Clinical Trial., PMID:40141452
Examining a role for irisin in treating cerebral ischemia., PMID:40135689
Irisin attenuates liver fibrosis by regulating energy metabolism and HMGB1/β-catenin signaling in hepatic stellate cells., PMID:40101858
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway., PMID:40086515
Irisin reverses high-fat diet-induced metabolic dysfunction via activation of brown adipose tissue in mice., PMID:40082597
Fndc5/irisin mediates the benefits of aerobic exercise intervention on aging-associated sarcopenia in mice., PMID:40080339
The Effects of Obesity, Six Weeks of Aerobic Training, and Cold Water Exposure on the Expression of FNDC5 and UCP1 Genes in Male Wistar Rats., PMID:40071055
Irisin decreases follicle development in cattle and inhibits theca cell steroidogenesis through focal adhesion kinase signaling., PMID:40062916
Prenatal irisin is inversely related to the term placental telomere length., PMID:40057798
Exercise induced irisin mitigates hepatitis in anabolic-androgenic steroids treated rats via modulation of PGC-1-α/PPARγ/Nrf2 and NRF2/NF-κB/TLR4 signaling., PMID:40054305
Irisin and liraglutide combination therapy mitigates myocardial reperfusion injury in obese rats: Role of endoplasmic reticulum stress and apoptosis., PMID:40049268
Beta(β)-sitosterol attenuates Chronic Unpredictable Stress (CUS) Induced Testicular Damage in the Experimental Rat Model., PMID:40044991
Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis., PMID:40044721
FNDC5/Irisin exacerbates APAP-induced acute liver injury through activating JNK/NF-κB and inflammatory response., PMID:40016523
Combined Treatment of Metformin and Resveratrol Promotes Myogenesis Through Increased Irisin Release in C2C12 Cells., PMID:40011370
For research use only. Not for human or drug use.
