Catalog No.
YHJ22401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala1008-Ser1227
Predicted molecular weight
26.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N6C5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PGSF2, Immunoglobulin superfamily member 1, Inhibin-binding protein, Pituitary gland-specific factor 2, IGSF1, p120, IGDC1, KIAA0364, Immunoglobulin-like domain-containing protein 1, IgSF1, InhBP
A Novel De Novo Nonsense Pathogenic Variant in IGSF1 Resulting in Central Hypothyroidism and Transient GH Deficiency., PMID:40162297
X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome., PMID:39996497
A proteomic atlas of glypican-3 interacting partners: Identification of alpha-fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer., PMID:39822733
Immunoglobulin superfamily member 1 upregulates myc proto-oncogene to accelerate invasion and metastasis of endometrial cancer: Molecular mechanisms and therapeutic prospects., PMID:39737117
Genome-wide statistical evidence elucidates candidate factors of life expectancy in dogs., PMID:39580055
Clinical and molecular analyses of isolated central congenital hypothyroidism based on a survey conducted in Japan., PMID:38462462
Congenital Central Hypothyroidism Caused by Novel Variants in IGSF1 Gene: Case Series of 3 Patients., PMID:38295770
The Immune Suppressor IGSF1 as a Potential Target for Cancer Immunotherapy., PMID:38289363
Hepatomegaly and fatty liver disease secondary to central hypothyroidism in combination with macrosomia as initial presentation of IGSF1 deficiency syndrome., PMID:37493943
[Clinical characteristics and genetic analysis of four patients with central hypothyroidism due to IGSF1 gene variants]., PMID:36854408
IGSF1 mutation as a cause of isolated central hypothyroidism., PMID:36464600
Integrated analysis identifies the IL6/JAK/STAT signaling pathway and the estrogen response pathway associated with the pathogenesis of intracranial aneurysms., PMID:36451838
IGSF1 mutations are the most frequent genetic aetiology of thyrotropin deficiency., PMID:36201163
Whole-genome sequencing identifies new candidate genes for nonobstructive azoospermia., PMID:36017582
Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome., PMID:35986704
IGSF1 Deficiency Leads to Reduced TSH Production Independent of Alterations in Thyroid Hormone Action in Male Mice., PMID:35708735
The extant immunoglobulin superfamily, member 1 gene results from an ancestral gene duplication in eutherian mammals., PMID:35653309
A Novel Pathogenic IGSF1 Variant in a Patient with GH and TSH Deficiency Diagnosed by High IGF-I Values at Transition to Adult Care., PMID:35466665
Case Report: A Detailed Phenotypic Description of Patients and Relatives with Combined Central Hypothyroidism and Growth Hormone Deficiency Carrying IGSF1 Mutations., PMID:35456429
Congenital Central Hypothyroidism Caused by a Novel IGSF1 Variant Identified in a French Family., PMID:35350016
Identification of novel prostate cancer genes in patients stratified by Gleason classification: Role of antitumoral genes., PMID:35234293
Diagnosis and Management of Central Congenital Hypothyroidism., PMID:34566885
Congenital isolated central hypothyroidism: Novel mutations and their functional implications., PMID:34225927
Estimating the accuracy of pharmacophore-based detection of cognate receptor-ligand pairs in the immunoglobulin superfamily., PMID:33483991
The IGSF1 Deficiency Syndrome May Present with Normal Free T4 Levels, Severe Obesity, or Premature Testicular Growth., PMID:33045800
A Case of Congenital Central Hypothyroidism Caused by a Novel Variant (Gln1255Ter) in IGSF1 Gene., PMID:32772515
Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction"., PMID:32211782
Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction"., PMID:32211768
IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction., PMID:31650157
A Tale of Two Proteins: Betaglycan, IGSF1, and the Continuing Search for the Inhibin B Receptor., PMID:31648935
Genetics of Congenital Isolated TSH Deficiency: Mutation Screening of the Known Causative Genes and a Literature Review., PMID:31504637
Hypoprolactinemia as a Clue to Diagnosis of Mild Central Hypothyroidism due to IGSF1 Deficiency., PMID:31448769
Recent advances in research on isolated congenital central hypothyroidism., PMID:31384098
IGSF1: A novel oncogene regulates the thyroid cancer progression., PMID:31343762
New genetic findings in a large cohort of congenital hypogonadotropic hypogonadism., PMID:31200363
Unraveling the LRC Evolution in Mammals: IGSF1 and A1BG Provide the Keys., PMID:31106814
Age-related gene and miRNA expression changes in airways of healthy individuals., PMID:30842487
The plasma peptides of ovarian cancer., PMID:30598658
A novel IGSF1 mutation in a large Irish kindred highlights the need for familial screening in the IGSF1 deficiency syndrome., PMID:30086211
Two siblings with congenital central hypothyroidism caused by a novel mutation in the IGSF1 gene., PMID:29662269
From Consternation to Revelation: Discovery of a Role for IGSF1 in Pituitary Control of Thyroid Function., PMID:29594256
Regulation and mechanism of miR-146 on renal ischemia reperfusion injury., PMID:29441948
A Japanese patient with congenital central hypothyroidism caused by a novel IGSF1 mutation., PMID:29425110
A Novel IGSF1 Mutation in a Boy With Short Stature and Hypercholesterolemia: A Case Report., PMID:29264525
The short mRNA isoform of the immunoglobulin superfamily, member 1 gene encodes an intracellular glycoprotein., PMID:28686733
Central Hypothyroidism Due to a TRHR Mutation Causing Impaired Ligand Affinity and Transactivation of Gq., PMID:28419241
TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice., PMID:28324000
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways., PMID:28262687
Analysis of large versus small dogs reveals three genes on the canine X chromosome associated with body weight, muscling and back fat thickness., PMID:28257443
Classical and non-classical causes of GH deficiency in the paediatric age., PMID:27974186
For research use only. Not for human or drug use.
