Catalog No.
YHJ21801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg56-Asp232
Predicted molecular weight
21.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N465
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
D-2-hydroxyglutarate dehydrogenase, mitochondrial, D2HGD, D2HGDH
Novel genetic associations with childhood adipocytokines in Indian adolescents., PMID:40187068
Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis., PMID:39565278
A cotton mitochondrial alternative electron transporter, GhD2HGDH, induces early flowering by modulating GA and photoperiodic pathways., PMID:38887925
Identification and validation of iron metabolism genes in osteoporosis., PMID:38169377
D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase., PMID:36724076
Australian genome-wide association study confirms higher female risk for adult glioma associated with variants in the region of CCDC26., PMID:36541697
DELAY OF GERMINATION 1 (DOG1) regulates dormancy in dimorphic seeds of Xanthium strumarium., PMID:35569923
d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation., PMID:35526742
In Silico Analysis of the L-2-Hydroxyglutarate Dehydrogenase Gene Mutations and Their Biological Impact on Disease Etiology., PMID:35456504
D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment., PMID:35007759
D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation., PMID:34296423
Kinetic and Bioinformatic Characterization of d-2-Hydroxyglutarate Dehydrogenase from Pseudomonas aeruginosa PAO1., PMID:33301690
Interaction network of proteins associated with unfavorable prognosis in acute myeloid leukemia., PMID:33284559
Prenatal diagnosis of partial monosomy 2q (2q37.3→qter) and partial trisomy 10q (10q24.31→qter) of paternal origin associated with increased nuchal translucency and abnormal maternal serum screening results., PMID:32917332
Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C., PMID:32386320
IDH1 mutated acute myeloid leukemia in a child with metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria., PMID:32166993
MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome., PMID:32101699
Biochemical characterization of human D-2-hydroxyglutarate dehydrogenase and two disease related variants reveals the molecular cause of D-2-hydroxyglutaric aciduria., PMID:31349060
Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations., PMID:31092874
D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants., PMID:30908763
d-2-Hydroxyglutarate dehydrogenase plays a dual role in l-serine biosynthesis and d-malate utilization in the bacterium Pseudomonas stutzeri., PMID:30131334
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2., PMID:29987523
Elevated d-2-hydroxyglutarate during colitis drives progression to colorectal cancer., PMID:29339485
Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis., PMID:28827360
Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer., PMID:27322736
[Analysis of L2HGDH gene mutation in a patient with 2-hydroxyglutaric aciduria]., PMID:26829733
The influence of alternative pathways of respiration that utilize branched-chain amino acids following water shortage in Arabidopsis., PMID:26616144
D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2., PMID:26178471
D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth., PMID:25825982
Derivatives containing both coumarin and benzimidazole potently induce caspase-dependent apoptosis of cancer cells through inhibition of PI3K-AKT-mTOR signaling., PMID:25811964
Mutant IDH1 inhibits PI3K/Akt signaling in human glioma., PMID:24771584
D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant., PMID:23551974
L-2 hydroxyglutaric aciduria as a rare cause of leukencephalopathy in adults., PMID:22840416
IDH1 and IDH2 have critical roles in 2-hydroxyglutarate production in D-2-hydroxyglutarate dehydrogenase depleted cells., PMID:22683334
Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma., PMID:21625441
Co-morbidity of Sanfilippo syndrome type C and D-2-hydroxyglutaric aciduria., PMID:21384162
Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence., PMID:21296880
Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations., PMID:20727073
Evolutionary history of D-lactate dehydrogenases: a phylogenomic perspective on functional diversity in the FAD binding oxidoreductase/transferase type 4 family., PMID:19727923
Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways., PMID:19586914
Measurement of D: -2-hydroxyglutarate dehydrogenase activity in cell homogenates derived from D: -2-hydroxyglutaric aciduria patients., PMID:19283509
Peripheral neuropathy in a patient with D-2-hydroxyglutaric aciduria., PMID:19169842
For research use only. Not for human or drug use.
