Catalog No.
YHJ20801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro300
Predicted molecular weight
37.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N1I0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DOCK4, KIAA0716, Dedicator of cytokinesis protein 4
A potential therapeutic molecule target: lncRNA AK023507 inhibits the metastasis of breast cancer by regulating the WNT/DOCK4/β-catenin axis., PMID:40205246
Transcytosis of LDL Across Arterial Endothelium: Mechanisms and Therapeutic Targets., PMID:40013359
Gene Expression Profiles in Ovarian Cancer Tissues as a Potential Tool to Predict Platinum-based Chemotherapy Resistance., PMID:39740837
The two major splice variants of scavenger receptor BI differ by their interactions with lipoproteins and cellular localization in endothelial cells., PMID:39393447
Gene-vegetarianism interactions in calcium, estimated glomerular filtration rate, and testosterone identified in genome-wide analysis across 30 biomarkers., PMID:38990837
HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia., PMID:38802496
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling., PMID:38762624
Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly., PMID:38526744
Integration analysis of lncRNA and mRNA expression data identifies DOCK4 as a potential biomarker for elderly osteoporosis., PMID:38443923
Multi-omics identification of GPCR gene features in lung adenocarcinoma based on multiple machine learning combinations., PMID:38213730
DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma., PMID:37702239
Identification and validation of differentially expressed genes for targeted therapy in NSCLC using integrated bioinformatics analysis., PMID:37324026
Prognostic biomarkers and molecular pathways mediating Helicobacter pylori-induced gastric cancer: a network-biology approach., PMID:37037466
Direct targeting of DOCK4 by miRNA-181d in oxygen-glucose deprivation/reoxygenation-mediated neuronal injury., PMID:36882763
Genetic variations in DOCK4 contribute to schizophrenia susceptibility in a Chinese cohort: A genetic neuroimaging study., PMID:36822513
Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice., PMID:36425784
KnockoffTrio: A knockoff framework for the identification of putative causal variants in genome-wide association studies with trio design., PMID:36150388
DOCK4 as a Potential Biomarker Associated with Immune Infiltration in Stomach Adenocarcinoma: A Database Analysis., PMID:35846794
Screening the hub genes and analyzing the mechanisms in discharged COVID-19 patients retesting positive through bioinformatics analysis., PMID:35657140
Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age., PMID:35635601
Dock4 is required for the maintenance of cochlear hair cells and hearing function., PMID:38933554
DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function., PMID:35477279
DOCK4 regulates ghrelin production in gastric X/A-like cells., PMID:35302184
Role of Rho guanine nucleotide exchange factors in non-small cell lung cancer., PMID:34783629
The Potential Role of AMPA Receptor Trafficking in Autism and Other Neurodevelopmental Conditions., PMID:34571086
Novel somatic variants involved in biochemical activity of pure growth hormone-secreting pituitary adenoma without GNAS variant., PMID:34400688
USP36-Mediated Deubiquitination of DOCK4 Contributes to the Diabetic Renal Tubular Epithelial Cell Injury via Wnt/β-Catenin Signaling Pathway., PMID:33968925
Altered postnatal developmental patterns of ultrasonic vocalizations in Dock4 knockout mice., PMID:33705839
DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation., PMID:33559155
Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children., PMID:33267929
Application of "omics" sciences to the prediction of bone metastases from breast cancer: State of the art., PMID:33240786
ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma., PMID:33202906
BMP-Induced MicroRNA-101 Expression Regulates Vascular Smooth Muscle Cell Migration., PMID:32635504
Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum., PMID:32576693
Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy., PMID:32143485
Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development., PMID:32009906
Effects of hub genes on the clinicopathological and prognostic features of lung adenocarcinoma., PMID:31966050
Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function., PMID:31388105
Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks., PMID:31308061
Long noncoding RNA AC073284.4 suppresses epithelial-mesenchymal transition by sponging miR-18b-5p in paclitaxel-resistant breast cancer cells., PMID:31215650
Active LDL trafficking drives atherosclerosis., PMID:31068687
SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis., PMID:31019307
Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer., PMID:30426503
Polarized Dock Activity Drives Shh-Mediated Axon Guidance., PMID:30078728
Interleukin 1 receptor antagonist and 2'-5'-oligoadenylate synthetase-like molecules as novel biomarkers for multiple sclerosis patients in Bahrain., PMID:29141788
DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression., PMID:28925399
The Drosophila DOCK family protein Sponge is required for development of the air sac primordium., PMID:28341448
Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes., PMID:26578796
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis., PMID:26129894
Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression., PMID:26048714
For research use only. Not for human or drug use.
