Catalog No.
YHJ20501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys261-Ala548
Predicted molecular weight
35.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N145
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LGI3, LGIL4, Leucine-rich repeat LGI family member 3, LGI1-like protein 4, Leucine-rich glioma-inactivated protein 3
Leucine rich repeat LGI family member 3: Integrative analyses support its prognostic association with pancreatic adenocarcinoma., PMID:38394487
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity., PMID:38194969
LGI3/2-ADAM23 interactions cluster Kv1 channels in myelinated axons to regulate refractory period., PMID:36828548
A reverse genetics and genomics approach to gene paralog function and disease: Myokymia and the juxtaparanode., PMID:35948005
LGI3 promotes human keratinocyte migration in high-glucose environments by increasing the expression of β-catenin., PMID:35751164
Integrative proteomic network analyses support depot-specific roles for leucine rich repeat LGI family member 3 in adipose tissues., PMID:34149883
Leucine-rich glioma inactivated 3: a novel keratinocyte-derived melanogenic cytokine in vitiligo patients., PMID:31644616
LGI3 is secreted and binds to ADAM22 via TRIF-dependent NF-κB pathway in response to LPS in human keratinocytes., PMID:31627033
Leucine rich repeat LGI family member 3: Integrative analyses reveal its prognostic association with non-small cell lung cancer., PMID:31452819
LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory., PMID:30346486
LGI3 promotes human keratinocyte differentiation via the Akt pathway., PMID:30091803
Next Generation Sequencing and Genome-Wide Genotyping Identify the Genetic Causes of Intellectual Disability in Ten Consanguineous Families from Jordan., PMID:29269699
Leucine-rich glioma inactivated 3: Integrative analyses reveal its potential prognostic role in cancer., PMID:29257304
Leucine-rich glioma inactivated 3: integrative analyses support its prognostic role in glioma., PMID:28579810
Leucine-rich glioma inactivated 3: Integrative analyses support its role in the cytokine network., PMID:28534931
Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB., PMID:25648289
Leucine-rich glioma inactivated 3 is a melanogenic cytokine in human skin., PMID:24903553
Leucine-rich glioma inactivated 3 promotes HaCaT keratinocyte migration., PMID:23815230
Leucine-rich glioma inactivated 3 associates negatively with adiponectin., PMID:23548727
Ultraviolet B-induced LGI3 secretion protects human keratinocytes., PMID:22741557
Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23., PMID:22405860
LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation., PMID:20461023
Leucine-rich glioma inactivated 3 induces neurite outgrowth through Akt and focal adhesion kinase., PMID:20162351
Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy., PMID:20133599
Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain., PMID:19833108
Leucine-rich glioma inactivated 3 associates with syntaxin 1., PMID:18760330
Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself., PMID:18628660
Immunohistochemical and biochemical analyses of LGI3 in monkey brain: LGI3 accumulates in aged monkey brains., PMID:17786549
Abeta upregulates and colocalizes with LGI3 in cultured rat astrocytes., PMID:17387609
Mouse LGI3 gene: expression in brain and promoter analysis., PMID:16545924
ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy., PMID:15857855
LGI1 mutations in temporal lobe epilepsies., PMID:15079010
Genotypic association of exonic LGI4 polymorphisms and childhood absence epilepsy., PMID:14505228
The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins., PMID:12023020
For research use only. Not for human or drug use.
