Catalog No.
YHJ19601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln389
Predicted molecular weight
70.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IXJ6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2, SIRT2, SIR2L2, SIR2L
Ononin modulates SIRT2-mediated glycolysis and inflammation in LPS-activated microglia via PKM2 deacetylation., PMID:40484108
Enhancing intestinal epithelial microtubule stability could alleviate IBD symptoms., PMID:40462136
Structural basis for sirtuin 2 activity and modulation: current state and opportunities., PMID:40412521
Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions., PMID:40390200
Therapeutic potential of dual HDAC6/SIRT2 inhibition in Alzheimer's disease., PMID:40381221
Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis., PMID:40379975
Proteostasis and autophagy disruption by the aging-related VGVAPG hexapeptide - preliminary insights into a potential novel elastin-induced neurodegeneration pathway in an in vitro human cellular neuron model., PMID:40348194
Fn14 Controls the SIRT2-Mediated Deacetylation of Slug to Inhibit the Metastasis of Epithelial Ovarian Cancer., PMID:40344622
Lead-Structure-Based Rigidization Approach to Optimize SirReal-Type Sirt2 Inhibitors., PMID:40333696
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress., PMID:40331334
SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells., PMID:40317067
Proximity extension assay reveals serum inflammatory biomarkers in two amyotrophic lateral sclerosis cohorts., PMID:40306441
Sirtuin 2 inhibitor AGK2 exerts antiviral effects by inducing epigenetic suppression of hepatitis B virus covalently closed circular DNA through recruitment of repressive histone lysine methyltransferases and reduction of cccDNA., PMID:40270769
Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice., PMID:40257511
Acetylation of Hsc70 at K512 inhibits goat ovarian granulosa cell senescence by restoring chaperone-mediated autophagy., PMID:40222521
SIRT2 suppresses aging-associated cGAS activation and protects aged mice from severe COVID-19., PMID:40220296
Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition., PMID:40209983
A Novel Aptamer-Based Fluorescent Biosensor for Imaging SIRT2 in Live Cells and Screening Its Modulators., PMID:40200675
Metformin activates SIRT2 to improve insulin resistance and promote granulosa cell glycolysis in a rat model of polycystic ovary syndrome., PMID:40199656
Microbiota-derived indole acetic acid extends lifespan through the AhR-Sirt2 pathway in Drosophila., PMID:40197001
Molecular Modeling, Synthesis, and Preliminary Cytotoxicity Evaluation of New Indole-Based Molecules as Possible Sirtuin Inhibitors., PMID:40175102
S-ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide-Induced Depression Via Targeting SIRT2., PMID:40171943
Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway., PMID:40166471
Hunting potential SIRT2 inhibitors towards cancer treatment: Drug repurposing, molecular dynamics, and binding energy computations., PMID:40158406
Role of SIRT3 in the regulation of Gadd45α expression and DNA repair in β-cells., PMID:40147772
The Clinical Role of SIRT-3 in the Acute Rejection Process of Kidney Transplantation and Its Effects on Graft Outcomes: Evaluation of Biomarker Potential., PMID:40142268
Hepatic microtubule destabilization facilitates liver fibrosis in the mouse model of Wilson disease., PMID:40140071
SIRT2 alleviates pre-eclampsia via prompting mitochondrial biogenesis and function., PMID:40118268
Sirtuin-2 Is Involved in the Regulation of Claudin-4 Expression and Paracellular Barrier Function in Keratinocytes., PMID:40114344
Novel Cyclopropene Probes as Chemical Reporters for Bioorthogonal Metabolic Labeling of Benzoylated Post-Translational Modification., PMID:40106725
Proteomic biomarkers in psoriatic arthritis., PMID:40096904
Integrated Proteomics and Lipidomics Analysis of Hippocampus to Reveal the Metabolic Landscape of Epilepsy., PMID:40092809
Suppression of Hepatocellular Carcinoma by Deletion of SIRT2 in Hepatocytes via Elevated C/EBPβ/GADD45γ., PMID:40081570
SIRT2 Regulates Apoptosis Signaling in Hyperoxic Acute Lung Injury., PMID:40067456
Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection., PMID:40050296
Succinylation of SERCA2a at K352 Promotes Its Ubiquitinoylation and Degradation by Proteasomes in Sepsis-Induced Heart Dysfunction., PMID:39996319
Lipopolysaccharide nanomedicine-based reversion of chemotherapy-induced metastatic potential of breast cancer via hampering tumoral TLR4/SIRT2 axis and IL6 secretion from tumor-associated macrophages., PMID:39993692
SIRT2 inhibition attenuates myofibroblast transition through autophagy-mediated ciliogenesis in renal epithelial cells., PMID:39988243
Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase., PMID:39985000
Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes., PMID:39965868
Admission glucose, HbA1c levels and inflammatory cytokines in patients with acute ST-elevation myocardial infarction., PMID:39962379
SIRT2 Regulates the SMARCB1 Loss-Driven Differentiation Block in ATRT., PMID:39960392
Transcriptome and single-cell profiling of the mechanism of diabetic kidney disease., PMID:39959271
Fragment Screening Reveals Novel Scaffolds against Sirtuin-2-Related Protein 1 from Trypanosoma brucei., PMID:39926558
Characterization of tubulin post-translational modifications and their enzymes during human oocyte meiosis., PMID:39920028
Modulation of sirtuin expression by a high-sugar diet and regular swimming trained precedes the loss of kidney function., PMID:39907422
Impact of hemolysis on the levels of proteins associated with aging and age-related neurodegenerative diseases in a multicentric clinical research., PMID:39906488
Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy., PMID:39905044
Piezo1-directed neutrophil extracellular traps regulate macrophage differentiation during influenza virus infection., PMID:39890818
Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury., PMID:39887347
For research use only. Not for human or drug use.
