Catalog No.
YHJ19301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu655-Val1119
Predicted molecular weight
55.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IX03
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kidney and brain protein, WWC1, Protein KIBRA, KIBRA, WW domain-containing protein 1, HBeAg-binding protein 3, KIAA0869
WWC1 mutation drives dopamine dysregulation and synaptic imbalance in Tourette's syndrome., PMID:40153501
PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes., PMID:40074086
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function., PMID:39841844
Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15-YAP Feedback Loop Promoting Tumor Metastasis., PMID:39686664
Is KIBRA polymorphism associated with memory performance and cognitive impairment in Alzheimer's disease?, PMID:39497316
WWC2 modulates GABAA-receptor-mediated synaptic transmission, revealing class-specific mechanisms of synapse regulation by WWC family proteins., PMID:39388350
Interaction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants., PMID:39214300
KIBRA anchoring the action of PKMζ maintains the persistence of memory., PMID:38924398
Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons., PMID:38917220
WWC1 upregulation accelerates hyperuricemia by reduction in renal uric acid excretion through Hippo signaling pathway., PMID:38906255
The influence of hippocampal dopamine D2 receptor losses on episodic-memory decline across 5 years is moderated by BDNF and KIBRA polymorphisms., PMID:38749085
Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice., PMID:38687825
Modulation of GABA A receptor trafficking by WWC2 reveals class-specific mechanisms of synapse regulation by WWC family proteins., PMID:38559047
JCAD deficiency delayed liver regenerative repair through the Hippo-YAP signalling pathway., PMID:38509842
Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway., PMID:38414246
KIBRA single nucleotide polymorphism is associated with hippocampal subfield volumes and cognition across development., PMID:37853296
Exogenous modification of EL-4 T cell extracellular vesicles with miR-155 induce macrophage into M1-type polarization., PMID:37817019
The Hippo signaling pathway contributes to the 2,5-Hexadion-induced apoptosis of ovarian granulosa cells., PMID:37563629
WWC1/2 regulate spinogenesis and cognition in mice by stabilizing AMOT., PMID:37528078
MEX3A determines in vivo hepatocellular carcinoma progression and induces resistance to sorafenib in a Hippo-dependent way., PMID:37460832
Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism., PMID:37347662
WWC2 expression in the testis: Implications for spermatogenesis and male fertility., PMID:37086090
Genetic bases of language control in bilinguals: Evidence from an EEG study., PMID:37051723
Two Hippo signaling modules orchestrate liver size and tumorigenesis., PMID:36919851
KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression., PMID:36853804
Regulation of Photosensitivity by the Hippo Pathway in Lupus Skin., PMID:36704840
KIBRA Gene Variant Is Associated with Ability in Chess and Science., PMID:36672945
Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study., PMID:36669907
Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning., PMID:36476872
TAOK1 Promotes Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells by Inhibition of WWC1., PMID:36158126
Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study., PMID:35972417
WWC1, a target of miR-138-5p, facilitates the progression of prostate cancer., PMID:35970246
BDNF and KIBRA Polymorphisms Are Related to Altered Resting State Network Connectivity in Middle Age., PMID:35599479
Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer., PMID:35489728
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy., PMID:35429439
KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion., PMID:35367771
GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study., PMID:35227251
Transcriptomic Analysis Reveals a Link Between Hippo Signaling Pathway and Macrophages in Lungs of Mice with OVA-Induced Allergic Asthma., PMID:35082511
KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients., PMID:35017578
Therapeutic Effects of Dietary Soybean Genistein on Triple-Negative Breast Cancer via Regulation of Epigenetic Mechanisms., PMID:34836197
Neuronal activation modulates enhancer activity of genes for excitatory synaptogenesis through de novo DNA methylation., PMID:34615840
Low KIBRA Expression Is Associated with Poor Prognosis in Patients with Triple-Negative Breast Cancer., PMID:34441043
Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p/WWC1 axis., PMID:34431595
Endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization., PMID:34216338
Binding of Ca2+-independent C2 domains to lipid membranes: A multi-scale molecular dynamics study., PMID:34081910
Lack of WWC2 Protein Leads to Aberrant Angiogenesis in Postnatal Mice., PMID:34070186
KIBRA connects Hippo signaling and cancer., PMID:33901448
ACTL6A promotes the growth in non-small cell lung cancer by regulating Hippo/Yap pathway., PMID:33896314
The Hippo pathway component Wwc2 is a key regulator of embryonic development and angiogenesis in mice., PMID:33483469
WWC Proteins: Important Regulators of Hippo Signaling in Cancer., PMID:33467643
For research use only. Not for human or drug use.
