Catalog No.
YHJ15401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln357-Leu580
Predicted molecular weight
27.88 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86U44
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
METTL3, N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase catalytic subunit, MTA70, Methyltransferase-like protein 3, MT-A70, hMETTL3
METTL3 promotes the hypertrophic scar fibrosis via m6A RNA methylation of GRAMD1B mRNA., PMID:40515792
METTL3-mediated SNHG1 m6A modification promotes proliferation and migration through transcriptional regulation of WDR74 in osteosarcoma., PMID:40510136
Targeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae., PMID:40510117
Increased METTL3 Expression and m6A Methylation in Myoblasts of Facioscapulohumeral Muscular Dystrophy., PMID:40507980
Dissecting the METTL3/STC2 axis in colorectal cancer: implications for drug resistance and metastasis., PMID:40494964
N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection., PMID:40493198
METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1., PMID:40492436
Inhibition of GRK4 reduces arrhythmia susceptibility and alleviates connexin43 dysregulation after myocardial infarction., PMID:40484036
Enterovirus 71 structural viral protein 1 promotes the expression of PMP22 through m6A modification in mouse Schwann cells., PMID:40480313
Role of USP10/METTL3/CXCR4 Axis in Immunotherapy of Castration-Resistant Prostate Cancer., PMID:40471642
METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway., PMID:40471098
Methyltransferase 3-mediated m6A modification of Switch/sucrose non-fermenting-related matrix-associated actin-dependent regulator of chromatin subfamily a member 5 promotes mycobacterium tuberculosis-infected macrophage M1 polarization and inflammation., PMID:40469707
A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1., PMID:40468363
ELF1-mediated transactivation of METTL3/YTHDF2 promotes nucleus pulposus cell senescence via m6A-dependent destabilization of E2F3 mRNA in intervertebral disc degeneration., PMID:40467575
Corrigendum to "METTL3-mediated HSPA9 m6A modification promotes malignant transformation and inhibits cellular senescence by regulating exosomal mortalin protein in cervical cancer" [Cancer Lett. 587 (2024) 216658]., PMID:40467353
METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA., PMID:40466953
METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage Differentiation., PMID:40464511
UBE2C, Regulated by n6-methyladenosine Methyltransferase METTL3, Is an Oncogene in Retinoblastoma via PI3K-AKT Pathway., PMID:40464106
Targeting METTL3 protein by proteolysis-targeting chimeras: A novel therapeutic approach for acute myeloid leukemia., PMID:40453361
METTL3-mediated m6A modification of FUNDC1/IP3R2 pathway facilitates cardiac hypertrophy in obesity hypertension., PMID:40451326
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer., PMID:40448344
Post-transcriptional regulation of H19 by m6A reader proteins: H19 stability versus miR-675 biogenesis., PMID:40447192
Identification and validation of pyroptosis-related genes in Alzheimer's disease based on multi-transcriptome and machine learning., PMID:40438507
An RNA transmethylation pathway governs kidney nephrogenic potential., PMID:40436842
RBM15-MKL1 fusion protein promotes leukemia via m6A methylation and WNT pathway activation., PMID:40435410
Knockdown of TRIM47 Overcomes Paclitaxel Resistance in Ovarian Cancer by Suppressing the TGF-β Pathway via PPM1A., PMID:40435048
The Impact of METTL3 on MDM2 Promotes Podocytes Injury During Diabetic Kidney Disease., PMID:40421968
Identification of biological markers and functional analysis in head and neck squamous cell carcinoma through Cuproptosis and methylation: molecular mechanism of action of METTL3 protein., PMID:40419066
METTL3‑mediated m6A methylation and its impact on OTUD1 expression in chronic obstructive pulmonary disease., PMID:40417884
[Eye acupuncture improves neural function in rats with cerebral ischemia-reperfusion injury by promoting angiogenesis via upregulating METTL3-mediated m6A methylation]., PMID:40415423
METTL3-dependent epigenetic regulation of ULK2 autophagy in hypertrophic scarring., PMID:40409645
METTL3 regulates ASMCs proliferation and M2 macrophage polarization via mediating the m6A methylation of TIMMDC1 in asthma., PMID:40409178
METTL3-mediated m6A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis., PMID:40409108
HNRNPA2B1-mediated m6A modification enhances lncRNA NORHA stability to control granulosa cell functions., PMID:40407136
GPCPD1 is regulated by METTL3/IGF2BP3 dependent m6A modification to affect pig muscle fiber type conversion., PMID:40404071
METTL3-Mediated m6A mRNA Modification Facilitates Neointimal Hyperplasia in Arteriovenous Fistula., PMID:40401375
Bisphenol Z inhibits the function of Leydig cells via upregulation of METTL3 expression in adult male rats., PMID:40398521
Genome-wide analysis of lncRNA m6A methylation in the mouse cortex after repetitive mild traumatic brain injury., PMID:40394496
METTL3-mediated m⁶A methylation in cardiac diseases: pathogenic roles and therapeutic potential., PMID:40394351
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery., PMID:40392368
METTL13 is essential for the survival of acute myeloid leukemia cells by regulating MYC., PMID:40382345
M6A Methylation Regulators METTL3 and ALKBH5 are Risk Factors for EGFR-Mutant NSCLC., PMID:40381190
Endotoxin-induced m6A RNA methylation landscape in lung endothelial cells: role of METTL3 in regulating inflammation and injury during acute lung injury., PMID:40379220
METTL3 promotes human amniotic epithelial stem cells differentiation into insulin-producing cells by regulation of MaFA expression., PMID:40374016
N6-methyladenosine-regulated exosome biogenesis orchestrates an immunosuppressive pre-metastatic niche in gastric cancer peritoneal metastasis., PMID:40370322
[Effect of Xingnao Kaiqiao acupuncture technique on m6A methylation modification in cortical area of rats with cerebral ischemia-reperfusion injury]., PMID:40369924
Nanopore direct RNA sequencing of human transcriptomes reveals the complexity of mRNA modifications and crosstalk between regulatory features., PMID:40359935
Complement C5a promotes human retinal pigment epithelial cell viability and migration through SLC38A1-mediated glutamine metabolism., PMID:40358757
METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy., PMID:40357551
Insights into the mechanism of METTL3-mediated m6A methylation in silicon dust-induced epithelial-mesenchymal transition., PMID:40354607
For research use only. Not for human or drug use.
