Catalog No.
YHJ13201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser58-Val146
Predicted molecular weight
11.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7RTR2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nucleotide-binding oligomerization domain protein 3, Caterpiller protein 16.2, CARD15-like protein, NLR family CARD domain-containing protein 3, NLRC3, CLR16.2, NOD3, NACHT, LRR and CARD domains-containing protein 3
Role of NLRC3 in modulating inflammatory responses in neonates., PMID:40437402
Comparative genomic analysis of immune-related genes and chemosensory receptors provides insights into the evolution and adaptation of four major domesticated Asian carps., PMID:40419972
P62 inhibits IL-1β release during Salmonella Typhimurium infection of macrophages., PMID:40276384
NLRC3 regulates RIP2, STING, TBK1, and TRAF6 mediated type I IFN signaling and inflammatory response in large yellow croaker Larimichthys crocea., PMID:40252745
Treg Cells Attenuate Pulmonary Venous Remodeling in PH-LHD via NLRC3 Signaling., PMID:40235449
The cGAS-STING-related signature affects the prognosis of colorectal cancer through its regulation of multiple immune cells., PMID:40035384
NLRC3 Attenuates Antiviral Innate Immune Response by Targeting IRF7 in Grass Carp (Ctenopharyngodon idelus)., PMID:39859554
NOD3 Reduces Sepsis-Induced Acute Lung Injury by Regulating the Activation of NLRP3 Inflammasome and the Polarization of Alveolar Macrophages., PMID:39621198
NLRC3 affects the development of psoriasis by modulating the NF-κB signaling pathway mediated inflammatory response through its interaction with TRAF6., PMID:39615555
MiR-130c-5p targets the SHVV n gene and upregulates immune cytokines (IL-6, IL-22, IL-1β) to inhibit viral replication., PMID:39555085
Effect of Heat Stress on the Expression of Circulating Cyto(chemo)kine and Inflammatory Markers in Broiler Chickens Selected for High- or Low-water Efficiency., PMID:39473418
[NLRC3 alleviates immune inflammatory response induced by macrophage pyroptosis in patients with rheumatoid arthritis by inhibiting STING signaling pathway]., PMID:39442970
Mechanism and Application Prospects of NLRC3 Regulating cGAS-STING Pathway in Lung Cancer Immunotherapy., PMID:39439455
Fish gut-derived probiotic Pediococcus pentosaceus alleviates gossypol-induced intestinal inflammation by inhibiting NLRC3/NF-κB/IL-1β signal pathway in Nile tilapia., PMID:39173982
MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells., PMID:39083380
Hepatopancreas Transcriptome Analysis of Spinibarbus sinensis to Reveal Different Growth-Related Genes., PMID:39062728
Harnessing paraprobiotics and postbiotics for enhanced immune function in Asian seabass (Lates calcarifer): Insights into pattern recognition receptor signaling., PMID:38925448
In vitro analysis of the expression of inflammasome, antiviral, and immune genes in an Oreochromis niloticus liver cell line following stimulation with bacterial ligands and infection with tilapia lake virus., PMID:38888759
Focus on negatively regulated NLRs in inflammation and cancer., PMID:38820966
Acacetin Attenuates Sepsis-induced Acute Lung Injury via NLRC3-NF-κB Pathway., PMID:38739343
Impact of weight loss on the expression of negative regulators of nuclear factorκB (NLRP12, NLRC3, and NLRX1) in subcutaneous adipose tissue., PMID:38573105
Dynamic bidirectional regulation of NLRC3 and gammaherpesviruses during viral latency in B lymphocytes., PMID:38445794
NLRC3 attenuates osteoclastogenesis by limiting TNFα+ Th17 cell response in osteoporosis., PMID:38436712
Regulation of NF-κB signaling by NLRC (NLRC3-like) gene in the common carp (Cyprinus carpio)., PMID:38301815
Sexual dimorphism in NLR transcripts and its downstream signaling protein IL-1ꞵ in teleost Channa punctata (Bloch, 1793)., PMID:38253695
Nlrc3 signaling is indispensable for hematopoietic stem cell emergence via Notch signaling in vertebrates., PMID:38172511
The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival., PMID:38129415
The evolution of NLRC3 subfamily genes in Sebastidae teleost fishes., PMID:37964222
Effects of leucism on organ development and molecular mechanisms in Northern snakehead (Channa argus) beyond pigmentation alterations., PMID:37952047
Weighted single-step genome-wide association study and functional enrichment analyses for gastrointestinal nematode resistance traits in Santa Ines sheep., PMID:37857178
NLRC3 negatively regulates Pasteurella multocida-induced NF-κB signaling in rabbits., PMID:37820760
NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-κB p65/HIF-1α pathway., PMID:37586455
Negative regulatory NLRs mitigate inflammation via NF-κB pathway signaling in inflammatory bowel disease., PMID:37321320
Triptoquinone A and B exercise a therapeutic effect in systemic lupus erythematosus by regulating NLRC3., PMID:37312878
Transcriptome Revealed the Macrophages Inflammatory Response Mechanism and NOD-like Receptor Characterization in Siberian Sturgeon (Acipenser baerii)., PMID:37298469
NLRC3 Participates in Inhibiting the Pulmonary Inflammatory Response of Sepsis-Induced Acute Lung Injury., PMID:37139806
The Green Walnut Husks Induces Apoptosis of Colorectal Cancer through Regulating NLRC3/PI3K Pathway., PMID:37005539
Identification of a novel fusion gene NLRC3-NLRP12 in miiuy croaker (Miichthys miiuy)., PMID:36965609
Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING., PMID:36952341
NLRC3 is a potential prognostic biomarker that is correlated with immune cell infiltration in lung adenocarcinoma., PMID:36808166
Comprehensive analysis of immune parameters, mRNA and miRNA profiles, and immune genes expression in the gill of rainbow trout infected with infectious hematopoietic necrosis virus (IHNV)., PMID:36646338
Overview of the anti-inflammatory function of the innate immune sensor NLRC3., PMID:36403432
Molecular characterization of NLRC3 and its interaction with other inflammasome components and regulation on the bacterial colonization in Qihe crucian carp Carassius auratus., PMID:36371052
Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases., PMID:36341336
Astragalus polysaccharides protect against inactivated Vibrio alginolyticus-induced inflammatory injury in macrophages of large yellow croaker., PMID:36206995
Involvement and characterization of NLRCs and pyroptosis-related genes in Nile tilapia (Oreochromis niloticus) immune response., PMID:36150410
NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-κB-NFAT5 complex during septic immunosuppression., PMID:36068919
NLRC3 deficiency promotes cutaneous wound healing due to the inhibition of p53 signaling., PMID:35963285
NLRC3 attenuates antiviral immunity and activates inflammasome responses in primary grouper brain cells following nervous necrosis virus infection., PMID:35750116
Negative Regulator Nlrc3-like Maintain the Balanced Innate Immune Response During Mycobacterial Infection in Zebrafish., PMID:35693809
For research use only. Not for human or drug use.
