Catalog No.
YHJ12201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro81-Tyr258
Predicted molecular weight
22.37 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q76M96
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CCDC80, Down-regulated by oncogenes protein 1, Coiled-coil domain-containing protein 80, URB, Up-regulated in BRS-3 deficient mouse homolog, DRO1
Roles of plasma proteins in mediating the causal effect of the lipid species on gastric cancer: Insights from proteomic and two-step Mendelian randomization., PMID:40388730
CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype., PMID:40278823
HDAC inhibitors modulate Hippo pathway signaling in hormone positive breast cancer., PMID:40012020
Genome-wide DNA methylation regulation analysis provides novel insights on post-radiation breast cancer., PMID:39955415
Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation., PMID:39919333
Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer., PMID:38872096
Targeted plasma proteomic analysis uncovers a high-performance biomarker panel for early diagnosis of gastric cancer., PMID:38631604
Functionally similar genes exhibit comparable/similar time-course expression kinetics in the UV-induced photoaged mouse model., PMID:37943888
Identification and Validation of Genes Exhibiting Dynamic Alterations in Response to Bleomycin-Induced Pulmonary Fibrosis., PMID:37924392
Influence of the concentrate inclusion level in a grass silage-based diet on hepatic transcriptomic profiles in Holstein-Friesian dairy cows in early lactation., PMID:37474362
Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis., PMID:37360572
Cross-tissue omics analysis discovers ten adipose genes encoding secreted proteins in obesity-related non-alcoholic fatty liver disease., PMID:37224770
Delivery of Engineered Primary Tumor-Derived Exosomes Effectively Suppressed the Colorectal Cancer Chemoresistance and Liver Metastasis., PMID:37141393
PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis., PMID:37047359
Exercise-derived peptide protects against pathological cardiac remodeling., PMID:35843176
The Value of the Stemness Index in Ovarian Cancer Prognosis., PMID:35741755
Search for New Target Genes of MicroRNA for Differential Diagnosis of Benign and Malignant Neoplasms of the Thyroid Gland by In Silico Methods., PMID:35737153
Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis., PMID:35422964
Antifibrotic activities of Scutellariae Radix extracts and flavonoids: Comparative proteomics reveals distinct and shared mechanisms., PMID:35397287
NOTCH2NLA silencing inhibits ovarian carcinoma progression and oncogenic activity in vivo and in vitro., PMID:34988178
Downregulation of the Coiled-Coil Domain Containing 80 and Its Perspective Mechanisms in Ovarian Carcinoma: A Comprehensive Study., PMID:34820451
Deficiency of coiled-coil domain containing 80 increases plasma cholesterol by decreasing fecal sterols excretion in hypercholesterolemic mice., PMID:34563664
Eight novel susceptibility loci and putative causal variants in atopic dermatitis., PMID:34116867
Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease., PMID:33676388
Multi-omics integrative analysis to access role of coiled-coil domain-containing 80 in lipid metabolism., PMID:32273086
Potential Biomarkers for Feed Efficiency-Related Traits in Nelore Cattle Identified by Co-expression Network and Integrative Genomics Analyses., PMID:32194642
Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models., PMID:32076068
A novel association of CCDC80 with gestational diabetes mellitus in pregnant women: a propensity score analysis from a case-control study., PMID:31992220
The Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript-1 Regulates CCDC80 Expression by Targeting miR-141-3p/miR-200a-3p in Vascular Smooth Muscle Cells., PMID:31934911
Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor., PMID:31712448
Cell type-dependent function of LATS1/2 in cancer cell growth., PMID:30531839
Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression., PMID:30439364
Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice., PMID:29901779
Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population., PMID:29531279
Adipose tissue and serum CCDC80 in obesity and its association with related metabolic disease., PMID:28850155
Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses., PMID:28793334
Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation., PMID:27645901
Comparative Transcriptome Analysis Identifies CCDC80 as a Novel Gene Associated with Pulmonary Arterial Hypertension., PMID:27375481
Epigenetic effects of prenatal estradiol-17β exposure on the reproductive system of pigs., PMID:27062901
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population., PMID:26496483
[Correlation between the expression level of coiled-coil domain-containing protein 80 and obesity]., PMID:26268870
The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias., PMID:25497869
The Coiled-Coil Domain Containing 80 (ccdc80) gene regulates gadd45β2 expression in the developing somites of zebrafish as a new player of the hedgehog pathway., PMID:25205658
DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice., PMID:25053805
Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms., PMID:25029241
Multiple roles of Equarin during lens development., PMID:24673466
Steroid-sensitive gene 1 is a novel cyclic GMP-dependent protein kinase I substrate in vascular smooth muscle cells., PMID:23831687
Tumor suppressor role of the CL2/DRO1/CCDC80 gene in thyroid carcinogenesis., PMID:23666966
Identification of steroid-sensitive gene-1/Ccdc80 as a JAK2-binding protein., PMID:23449887
Equarin is involved in cell adhesion by means of heparan sulfate proteoglycan during lens development., PMID:23161803
For research use only. Not for human or drug use.
