Catalog No.
YHJ11401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met227-Asp400
Predicted molecular weight
21.11 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6ZVN8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hemojuvelin BMP coreceptor, HJV, RGMC, RGM domain family member C, Hemochromatosis type 2 protein, Hemojuvelin, HFE2
Hypoferremic Response to Chronic Inflammation Is Controlled via the Hemojuvelin/Hepcidin/Ferroportin Axis and Does Not Involve Hepcidin-Independent Regulation of Fpn mRNA., PMID:40347094
Assessment of HJV and SMN1 gene expression levels in infertile men: laboratory and bioinformatic approaches., PMID:40140146
The Loss of HJV Aggravates Muscle Atrophy by Promoting the Activation of the TβRII/Smad3 Pathway., PMID:40076640
Antibiofilm Activities of Tritrpticin Analogs Against Pathogenic Pseudomonas aeruginosa PA01 Strains., PMID:40005137
[A case of type 2A juvenile hereditary hemochromatosis]., PMID:39806903
[Analysis of clinical, gene mutation characteristics, and treatment prognosis of type 2A hereditary hemochromatosis in the Chinese population]., PMID:39623577
Bone phenotyping of murine hemochromatosis models with deficiencies of Hjv, Alk2, or Alk3: The influence of sex and the bone compartment., PMID:39545682
Hepcidin expression is associated with increased γ-secretase-mediated cleavage of neogenin in the liver., PMID:39454953
Bile from the hemojuvelin-deficient mouse model of iron excess is enriched in iron and ferritin., PMID:39313333
Insights into Iron Metabolism Parameters in Ischemic Stroke: A Single-Center Prospective Cohort Study., PMID:39273300
Hereditary haemochromatosis: Prevalence and characterization of the disease in a tertiary hospital in Aragon, Spain., PMID:39003111
Investigation of BMP6 mutations in Brazilian patients with iron overload., PMID:38719717
Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial., PMID:38670135
Hemojuvelin-mediated hepcidin induction requires both bone morphogenetic protein type I receptors ALK2 and ALK3., PMID:38588481
First-in-Human Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Pharmacodynamics of DISC-0974, an Anti-Hemojuvelin Antibody, in Healthy Participants., PMID:38515275
HJV mutations causing hemochromatosis: variable phenotypic expression in a pair of twins., PMID:38450514
The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity., PMID:38310100
Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth., PMID:38218852
Circulating microRNAs and hepcidin as predictors of iron homeostasis and anemia among school children: a biochemical and cross-sectional survey analysis., PMID:38102707
Haemochromatosis in children: A national retrospective cohort promoted by the A.I.E.O.P. (Associazione Italiana Emato-Oncologia Pediatrica) study group., PMID:37990447
Characterization of fifteen key genes involved in iron metabolism and their responses to dietary iron sources in yellow catfish Pelteobagrus fulvidraco., PMID:37716208
FGF21 and GDF15 are elevated in Barth Syndrome and are correlated to important clinical measures., PMID:37549445
Bioinformatics Analysis of the Genetic and Epigenetic Alterations of Bone Morphogenetic Protein Receptors in Metastatic Breast Cancer., PMID:37486509
Primary Non-HFE Hemochromatosis: A Review., PMID:37408807
Hereditary hemochromatosis: An update vision of the laboratory diagnosis., PMID:37163822
Genetic Variations of ferroportin-1(FPN1-8CG), TMPRSS6 (rs855791) and Hemojuvelin (I222N and G320V) Among a Cohort of Egyptian β-Thalassemia Major Patients., PMID:37006987
Cardiac Hamp mRNA Is Predominantly Expressed in the Right Atrium and Does Not Respond to Iron., PMID:36982241
Managing the Dual Nature of Iron to Preserve Health., PMID:36835406
Genetic Iron Overload Hampers Development of Cutaneous Leishmaniasis in Mice., PMID:36675185
Machine learning for the prediction of acute kidney injury in patients after cardiac surgery., PMID:36157418
A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice., PMID:36066082
Effect of Cyclic Heat Stress on Hypothalamic Oxygen Homeostasis and Inflammatory State in the Jungle Fowl and Three Broiler-Based Research Lines., PMID:35692291
Goat Milk Based Infant Formula in Newborns: A Double-Blind Randomized Controlled Trial on Growth and Safety., PMID:35666856
Hepcidin is potential regulator for renin activity., PMID:35442992
Hepcidin in hepatocellular carcinoma., PMID:35264787
Estimates of West African Ancestry in African Americans Using Alleles of Iron-Related Genes HJV, SLC40A1, and TFR2., PMID:35225679
Hemojuvelin deficiency promotes liver mitochondrial dysfunction and predisposes mice to hepatocellular carcinoma., PMID:35194137
New Mutations in HFE2 and TFR2 Genes Causing Non HFE-Related Hereditary Hemochromatosis., PMID:34946929
Identification of Novel Mutations by Targeted NGS Panel in Patients with Hyperferritinemia., PMID:34828384
Correlation of genotype and phenotype in 32 patients with hereditary hemochromatosis in China., PMID:34583728
Tissue-Specific Regulation of Ferroportin in Wild-Type and Hjv-/- Mice Following Dietary Iron Manipulations., PMID:34558857
Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies., PMID:34258619
SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia., PMID:33942901
Hepatocyte neogenin is required for hemojuvelin-mediated hepcidin expression and iron homeostasis in mice., PMID:33824974
Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice., PMID:33800732
Iron chelators reverse organ damage in type 4B hereditary hemochromatosis: Case reports., PMID:33787609
[A case of ferroportin disease with phenotype A gene mutation in SCL40A1 resembling phenotype B manifestation influenced by alcohol consumption]., PMID:33298676
A high-fructose diet in rats induces systemic iron deficiency and hepatic iron overload by an inflammation mechanism., PMID:33289147
Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model., PMID:33180328
For research use only. Not for human or drug use.
