Catalog No.
YHJ08601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu123-Pro343
Predicted molecular weight
26.73 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UWB1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-27R subunit alpha, IL-27RA, ZcytoR1, Interleukin-27 receptor subunit alpha, Cytokine receptor WSX-1, IL-27R-alpha, IL-27 receptor subunit alpha, CRL1, WSX1, TCCR, IL27RA, Type I T-cell cytokine receptor, Cytokine receptor-like 1
Integrative transcriptomic and single-cell analysis reveals IL27RA as a key immune regulator and therapeutic indicator in breast cancer., PMID:40450602
IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination., PMID:40328205
Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies., PMID:40299566
IL-27 accelerates diabetic wound healing by modulating macrophage polarization., PMID:40199138
P2RX7, an adaptive immune response gene, is associated with Parkinson's disease risk and age at onset., PMID:39957192
The influence of interleukin-27 on metabolic fitness in a murine neonatal model of bacterial sepsis., PMID:39810405
Integrative Proteogenomic Analyses Provide Novel Interpretations of Type 1 Diabetes Risk Loci Through Circulating Proteins., PMID:39761376
IL-27 attenuated macrophage injury and inflammation induced by Mycobacterium tuberculosis by activating autophagy., PMID:39455490
Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications., PMID:39422056
Interleukin-27 signaling resists obesity by promoting the accumulation of Treg cells in visceral adipose tissue., PMID:39276693
Exploring the relationship between the interleukin family and lung adenocarcinoma through Mendelian randomization and RNA sequencing analysis., PMID:39264458
Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet., PMID:39153664
The Integrated Bioinformatic Approach Reveals the Prognostic Significance of LRP1 Expression in Ovarian Cancer., PMID:39063239
IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation., PMID:38982043
Regulation of memory CD4+ T-cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection., PMID:38895753
IL-27 promotes pathogenic T cells in a mouse model of Sjögren's disease., PMID:38788885
Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency., PMID:38509369
IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells., PMID:38117410
Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure., PMID:38062819
Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia., PMID:37345470
Tr1 cell-mediated protection against autoimmune disease by intranasal administration of a fusion protein targeting cDC1 cells., PMID:37192682
Cytokine receptor IL27RA is an NF-κB-responsive gene involved in CD38 upregulation in multiple myeloma., PMID:36867577
IL-27 deficiency inhibits proliferation and invasion of trophoblasts via the SFRP2/Wnt/β-catenin pathway in fetal growth restriction., PMID:36860682
Structural insights into the assembly and activation of the IL-27 signaling complex., PMID:35920255
Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G., PMID:35862195
IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma., PMID:35723626
Structure of the IL-27 quaternary receptor signaling complex., PMID:35579417
IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis., PMID:35430461
IL-27 Enhances γδ T Cell-Mediated Innate Resistance to Primary Hookworm Infection in the Lungs., PMID:35354611
Identification of key genes associated with polycystic ovary syndrome (PCOS) and ovarian cancer using an integrated bioinformatics analysis., PMID:35227296
Identification and functional characterization of interleukin-12 receptor beta 1 and 2 in grass carp (Ctenopharyngodon idella)., PMID:35042118
B cell-derived IL-27 promotes control of persistent LCMV infection., PMID:35022243
TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4+ T Lymphocytes., PMID:34996840
NOTCH2NLA silencing inhibits ovarian carcinoma progression and oncogenic activity in vivo and in vitro., PMID:34988178
Adaptive Immune Response Signaling Is Suppressed in Ly6Chigh Monocyte but Upregulated in Monocyte Subsets of ApoE-/- Mice - Functional Implication in Atherosclerosis., PMID:34987524
IL-27 signalling promotes adipocyte thermogenesis and energy expenditure., PMID:34819664
IL-27 Mediates Pro-Inflammatory Effects via the ERK Signaling Pathway During Preterm Labor., PMID:34691022
Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin., PMID:34623903
A prospective study revealing the role of an immune-related eRNA, WAKMAR2, in breast cancer., PMID:34321580
Deficiency of IL-27 Signaling Exacerbates Experimental Autoimmune Uveitis with Elevated Uveitogenic Th1 and Th17 Responses., PMID:34299138
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression., PMID:34108491
Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro., PMID:34061845
A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cells., PMID:34050263
TLR7 Agonist Suppresses Group 2 Innate Lymphoid Cell-mediated Inflammation via IL-27-Producing Interstitial Macrophages., PMID:34003734
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses., PMID:33871355
IL-27/IL-27R Mediates Protective Immunity against Chlamydial Infection by Suppressing Excessive Th17 Responses and Reducing Neutrophil Inflammation., PMID:33863788
IL-27 Rα+ cells promoted allorejection via enhancing STAT1/3/5 phosphorylation., PMID:32761753
Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses., PMID:32522836
The contribution from interleukin-27 towards rheumatoid inflammation: insights from gene expression., PMID:32518420
Impaired Interleukin-27-Mediated Control of CD4+ T Cell Function Impact on Ectopic Lymphoid Structure Formation in Patients With Sjögren's Syndrome., PMID:32307922
For research use only. Not for human or drug use.
